Abstract: A shackle assembly includes a shackle body having two shackle arms extending from a bridge portion which is fixed to the two arms and connects the two arms to each other. A shackle pin can be mounted to the shackle arms and connects the two shackle arms in the mounted state. At least one pocket is formed in at least one of the shackle arms and/or the shackle pin, in which pocket a strain sensing element is received and fixedly attached to the bottom or wall of the pocket for detecting a shackle load acting on the shackle assembly. The pocket is a hole going partially through the shackle arm or going partially through the shackle pin, and the strain sensing element is a strain gauge which is attached to the wall or bottom of the hole.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: Disclosed is a pickup assembly for stringed musical instruments with improved acoustic sound quality, and related methods. In one embodiment, the pickup features, three mechanisms for converting the mechanical vibrations of the instrument into an electric signal: first, a mechanism for converting the vibrations of the instruments strings into an electric signal; second, a acoustic chamber mechanism for converting the vibrations of the sound box (e.g. sound waves) into an electric signal; and third, a mechanism for converting the vibrations of the instruments head into an electric signal.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: A shackle assembly includes a shackle body having two shackle arms extending from a bridge portion which is fixed to the two arms and connects the two arms to each other. A shackle pin can be mounted to the shackle arms and connects the two shackle arms in the mounted state. At least one pocket is formed in at least one of the shackle arms and/or the shackle pin, in which pocket a strain sensing element is received and fixedly attached to the bottom or wall of the pocket for detecting a shackle load acting on the shackle assembly. The pocket is a hole going partially through the shackle arm or going partially through the shackle pin, and the strain sensing element is a strain gauge which is attached to the wall or bottom of the hole.

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R3, A, B, X, Y and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R6, A, B, X, Y and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: The invention relates to a method for compensating patient movements in MRI scans in real time and to a device suitable for carrying out said method. The method involves the following steps: optically sensing a marking element (5) connected to a patient (3) by means of an image sensor module (7) of an MRI-compatible camera (2) which is positioned inside an MRI device; transferring the image data detected by the image sensor module (7) to a micro-controller module (11) which is integrated in the MRI-compatible camera (2); calculating position data of the marking element (5) in the micro-controller module (11); and transmitting the position data to an external analyzing unit or to the MRI device in real time.

Abstract: A utility vehicle is provided that includes first and second pairs of wheels, a controller, and a potentiometer. The first pair of wheels is propelled by an internal combustion engine. The second pair of wheels is propelled by a battery-operated motor. The motor drives a transaxle that drives the second pair of wheels. The controller controls operation of the motor. The potentiometer is configured to be manually activated to propel the utility vehicle, and is coupled to the controller to send a signal to the controller to rotate the motor. The potentiometer is also configured to activate fuel flow into the internal combustion engine.

Abstract: The invention relates to a method for optimization of the performance of a multi-channel coil (1) comprising at least three coil elements, wherein the method comprises the following steps: a) Exciting the coil elements of the multi-channel coil (1) by electrical power signals comprising a specific power, wherein the power of the power signals is partially reflected by the coil elements of the multi-channel coil (1), b) Measuring the power which is reflected by the individual coil elements of the multi-channel coil (1) or by the entire multi-channel coil (1) during excitation of the coil elements, c) Tuning the multi-channel coil (1) depending on the measured reflected power so that the performance of the multi-channel coil (1) is improved, wherein d) all coil elements of the multi-channel coil (1) are simultaneously excited, and e) the reflected power is measured during the simultaneous excitation of all coil elements of the multi-channel coil (1).

Abstract: Systems and methods are disclosed for providing proprietary access to a server. The disclosed systems and methods may include receiving a first service request from a client. The first service request may include a client identifier. Furthermore, the disclosed systems and methods may include creating a session identifier when it is determined that the client identifier is valid and transmitting the session identifier to the client. Moreover, the disclosed systems and methods may include receiving a second service request from the client. The second service request may include the session identifier and client data that may have at least one of a proprietary format and a proprietary scheme. In addition, the disclosed systems and methods may include servicing the second service request when it is determined that the session identifier received in the second service request is valid.

Abstract: A device (1) for aligning a guide wire with a bone, comprising: an attachment means (2) reversibly attachable to a bone; an alignment means (31) connected to the attachment means, the alignment means being moveable so as to locate a portion of the bone for insertion of the guide wire. A method for aligning a guide wire with a bone.

Abstract: A device (1) for connecting to an implant (16), comprising: at least two protrusions (8, 9) connectable, in use, to at least one indentation (20) in the implant; and a mechanism for moving the protrusions between a connected and a disconnected position. An implant (16) comprising a body (17) having at least one indentation (20) disposed within the body, wherein, in use, the at least one indentation receives at least two protrusions (8, 9) of a device (1) for connecting to the implant (16) such that the implant is clamped by the device. A method of connecting an implant (16) to a device (1).

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R6, A, B, X, Y and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.