Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The invention relates to a method for compensating patient movements in MRI scans in real time and to a device suitable for carrying out said method. The method involves the following steps: optically sensing a marking element (5) connected to a patient (3) by means of an image sensor module (7) of an MRI-compatible camera (2) which is positioned inside an MRI device; transferring the image data detected by the image sensor module (7) to a micro-controller module (11) which is integrated in the MRI-compatible camera (2); calculating position data of the marking element (5) in the micro-controller module (11); and transmitting the position data to an external analyzing unit or to the MRI device in real time.

Abstract: A utility vehicle is provided that includes first and second pairs of wheels, a controller, and a potentiometer. The first pair of wheels is propelled by an internal combustion engine. The second pair of wheels is propelled by a battery-operated motor. The motor drives a transaxle that drives the second pair of wheels. The controller controls operation of the motor. The potentiometer is configured to be manually activated to propel the utility vehicle, and is coupled to the controller to send a signal to the controller to rotate the motor. The potentiometer is also configured to activate fuel flow into the internal combustion engine.

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: A method and apparatus are directed to a dynamic means for correcting imbalance and harmonic distortion in an electrical system. In one embodiment, the device includes an imbalance and harmonics measurement module configured to measure power parameters for determining imbalance and harmonics within the electrical three-phase system. Within this system a series of capacitors are configured to respond to measured demands reported and designated to correct for imbalance and harmonics distortion. The device is networked among various source load controllers are responsible for designating master and slave relationships within the closed system.

Abstract: A utility vehicle is provided that includes first and second pairs of wheels, a controller, and a potentiometer. The first pair of wheels is propelled by an internal combustion engine. The second pair of wheels is propelled by a battery-operated motor. The motor drives a transaxle that drives the second pair of wheels. The controller controls operation of the motor. The potentiometer is configured to be manually activated to propel the utility vehicle, and is coupled to the controller to send a signal to the controller to rotate the motor. The potentiometer is also configured to activate fuel flow into the internal combustion engine.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The invention relates to a method for optimization of the performance of a multi-channel coil (1) comprising at least three coil elements, wherein the method comprises the following steps: a) Exciting the coil elements of the multi-channel coil (1) by electrical power signals comprising a specific power, wherein the power of the power signals is partially reflected by the coil elements of the multi-channel coil (1), b) Measuring the power which is reflected by the individual coil elements of the multi-channel coil (1) or by the entire multi-channel coil (1) during excitation of the coil elements, c) Tuning the multi-channel coil (1) depending on the measured reflected power so that the performance of the multi-channel coil (1) is improved, wherein d) all coil elements of the multi-channel coil (1) are simultaneously excited, and e) the reflected power is measured during the simultaneous excitation of all coil elements of the multi-channel coil (1).

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: A dynamic high-energy switch used for correcting load imbalance through connecting and disconnecting capacitance in a power feed circuit.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R3, A, B, X, and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.