Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

Abstract: Disclosed herein is a device configured to covertly communicate state information within a transmitter address field of a message. The device comprises a memory configured to store a state key and state information of the device, and a controller in communication with the memory. The controller is configured to apply a one-way function, using the state key, to the state information to produce a transmitter address, and transmit the message, including the transmitter address in the transmitter address field of the message.

Abstract: A method of installing a sensor pod on a vehicle includes aligning a sensor pod arm with a bracket attached to the vehicle, lowering the sensor pod arm onto the bracket, supporting the weight of the sensor pod on a support axle between the bracket and the sensor pod arm before rigidly coupling the sensor pod arm to the bracket, rotating the sensor pod arm into alignment with the bracket, and securing the sensor pod arm to the bracket. A method of uninstalling the sensor pod on a vehicle.

Abstract: A universal bracket for connecting a sensor pod and a vehicle. The universal bracket includes a first end having a surface for connecting to the vehicle, a second end for connecting to the sensor pod, three fixation points extending perpendicular to and through the surface for preventing lateral movement, vertical movement, and forward movement of the universal bracket with respect to the vehicle, the three fixation further preventing rotational movement of the universal bracket with respect to the vehicle, and at least one port extending from the first end to the second end, the at least one port configured to allow passage of one or more conduits extending from the vehicle to the sensor pod. A connecting assembly includes the universal bracket.

Abstract: A connecting assembly for connecting sensors in a sensor pod to a vehicle. The connecting assembly has a conduit connector located on a housing of the sensor pod, a conduit configured to connect with the conduit connector and extending from the conduit connector to the vehicle, and a conduit connector point located at a connection between the conduit connector and the conduit. The conduit connector point has a first shear strength when the conduit is in tension and the conduit has a second shear strength when the conduit is in tension. The first shear strength is less than the second shear strength.

Abstract: A quick swap sensor pod for a truck having an arm having a protrusion with a lower surface, a pin receiving opening extending through the protrusion to the lower surface, the pin receiving opening having a depth and aligned vertically, and a conduit connector within the arm for coupling a conduit to the quick swap sensor pod. The arm is configured to rotate about an axis of the pin receiving opening between an initial position and a final position. In both the initial position and the final position, the depth of the pin receiving opening is configured to counteract a moment created by a weight of the quick swap sensor pod and the lower surface is configured to support the weight of the quick swap sensor pod.

Abstract: An apparatus for reducing damage and debris in a sensor pod collision. The apparatus having a bracket configured to couple a sensor pod to a vehicle, the bracket having a post, a sensor pod arm rotatable about the post, a fastener for securing the sensor pod arm to the post, and a frangible fixation point spaced apart from the post, the frangible fixation point configured to break apart at a predetermined force.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine uses a cryptographic key to decrypt the encrypted user content data stored on the storage medium in response to a request from the host computer system. An access controller receives a request from a manager device to initialize the data storage device. The controller generates the cryptographic key, generates a manager key configured to provide manager access for the manager device and provide access to the cryptographic key, and stores, on a data store, authorization data indicative of the manager key and accessible based on a private key stored on the manager device.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. Multiple manager device records each comprise a first key identical for each of the records, and a second key that different for each of the records. The controller generates an authorization request using the first key and receives a response to the request generated by a manager device. The response is specific to that manager device. The controller uses the response to locate the record; decrypts the located manager device record to obtain key data; and generates configuration data based on the key data to register the device.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. The access controller generates authorization request data indicative of multiple devices to be authorized, and stores the authorization request data on non-volatile configuration memory of the data storage device. Upon approval of the authorization request data by a manager device that is registered with the access controller as a manager device, the access controller locates the authorization request data of one of the multiple devices to be authorized and registers the one of the multiple devices to be authorized as an authorized device.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. The access controller generates an authorization request for a manager device. The authorization request comprises a certificate. The certificate comprising key data. In response to receiving the key data in a response to the authorization request generated by the manager device, the access controller generates configuration data based on the key data to register the device to be authorized as an authorized device.

Abstract: A blowout preventer system including a lower blowout preventer stack comprising a number of hydraulic components, and a lower marine riser package comprising a first control pod and a second control pod adapted to provide, during use, redundant control of hydraulic components of the lower blowout preventer stack where the first and the second control pods are adapted to being connected, during use, to a surface control system and to be controlled, during use, by the surface control system. The blowout preventer system further including at least one additional control pod connected to at least one additional surface control system and to be controlled, during use, by the additional surface control system.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, R1-R8, and n are defined herein. The novel benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

Abstract: This disclosure relates to a data storage device. A data port transmits data between a host computer system and the data storage device over a data channel. The device repeatedly broadcasts advertising packets over a wireless communication channel different from the data channel. Each advertising packet comprises a random value and a message authentication code calculated based on the random value and an identity key. The identity key is readable by a device to be connected and in proximity of the data storage device out of band of the data channel and the communication channel. The identity key enables the device to be connected to verify the message authentication code based on the random value and the identity key to thereby authenticate the data storage device.

Abstract: Disclosed herein is a data storage device comprising a data path and an access controller. The data path comprises a data port configured to transmit data between a host computer and the data storage device. The data storage device is configured to register with the host computer as a block data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine is connected between the data port and the storage medium and uses a cryptographic key to decrypt the encrypted user content data. The access controller generates a challenge for an authorized device; sends the challenge to the authorized device; receives a response to the challenge from the authorized device over the communication channel; calculates the cryptographic key based on the response; and provides the cryptographic key to the cryptography engine to decrypt the encrypted user content data stored on the storage medium.

Abstract: A blowout preventer system including a lower blowout preventer stack comprising a number of hydraulic components, and a lower marine riser package comprising a first control pod and a second control pod adapted to provide, during use, redundant control of hydraulic components of the lower blowout preventer stack where the first and the second control pods are adapted to being connected, during use, to a surface control system and to be controlled, during use, by the surface control system. The blowout preventer system further including at least one additional control pod connected to at least one additional surface control system and to be controlled, during use, by the additional surface control system.

Abstract: The present disclosure relates generally to molded rod mounts for shower/bathing systems. In particular, the present disclosure provides at least one molded rod mount having a first wall body including a first recess configured to receive a first end of a rod. The first recess includes an axis perpendicular to the first wall body, a first curved portion having a first depth and a first radius of curvature relative to the axis, and a first rear portion adjacent to the first curved portion. A second recess is disposed opposite the first recess on a second wall body opposite the first wall body.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. The access controller receives from a manager device a public key. The public key is associated with a private key stored on a device to be authorized. The controller determines a user key that provides access to the cryptographic key; encrypts the user key based on the public key and such that the user key is decryptable based on the private key stored on the device to be authorized; and stores, on the data store, authorization data indicative of the encrypted user key.

Abstract: A blowout preventer system including a lower blowout preventer stack comprising a number of hydraulic components, and a lower marine riser package comprising a first control pod and a second control pod adapted to provide, during use, redundant control of hydraulic components of the lower blowout preventer stack where the first and the second control pods are adapted to being connected, during use, to a surface control system and to be controlled, during use, by the surface control system. The blowout preventer system further including at least one additional control pod connected to at least one additional surface control system and to be controlled, during use, by the additional surface control system.

Abstract: This disclosure relates to a data storage device. A data port transmits data between a host computer system and the data storage device over a data channel. The device repeatedly broadcasts advertising packets over a wireless communication channel different from the data channel. Each advertising packet comprises a random value and a message authentication code calculated based on the random value and an identity key. The identity key is readable by a device to be connected and in proximity of the data storage device out of band of the data channel and the communication channel. The identity key enables the device to be connected to verify the message authentication code based on the random value and the identity key to thereby authenticate the data storage device.