Abstract: A blowout preventer system including a lower blowout preventer stack comprising a number of hydraulic components, and a lower marine riser package comprising a first control pod and a second control pod adapted to provide, during use, redundant control of hydraulic components of the lower blowout preventer stack where the first and the second control pods are adapted to being connected, during use, to a surface control system and to be controlled, during use, by the surface control system. The blowout preventer system further including at least one additional control pod connected to at least one additional surface control system and to be controlled, during use, by the additional surface control system.

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: A method of measuring a flow rate of a fluid flowing in a space between an outer conduit and an inner element in the outer conduit is provided. Ultrasonic waves are transmitted and received through the space between multiple pairs of ultrasonic transducers along multiple propagation paths, respectively. A mean line velocity of the fluid is calculated based on data from each pair of ultrasonic transducers. As such, multiple mean line velocities across the space are obtained. The flow rate of the fluid is calculated based on the multiple mean line velocities.

Abstract: An ultrasonic flow meter system includes a conduit defining a channel, at least one pair of first transducers, at least one second transducer, and a processor. The pair of first transducers is mounted on the conduit and includes a transmitting transducer and a receiving transducer for generating a first responsive signal. The transmitting transducer and the receiving transducer are arranged on a chordal path. The second transducer is mounted on the conduit for generating a second responsive signal. The processor is configured to receive the first responsive signal and the second responsive signal, select one responsive signal according to a relationship of the first responsive signal and noise thereof and a relationship of the second responsive signal and noise thereof, and determine a flow rate of a flow medium according to the selected responsive signal. A method for measuring the flow rate of the fluid medium is also provided.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: This invention relates to compounds of general formula in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salts, and to methods of using such compounds, salts and compositions.

Abstract: A golf swing alignment and swing-aiming device is disclosed. An embodiment of the device includes a main elongated member, an aim arm that is pivotally connected to the main elongated member, an aiming strip that is pivotally connected to the aim arm, and a ball positioning arm that is pivotally connected to the main member at a location near the second end of the main member. The device collapses so that it can fit inside a club sheath in a golf bag, and can be unfolded to allow the user to position the aiming strip in a parallel arrangement with the main member, so that the aiming strip can be used to guide the swing of a golf club while positioning one's feet along the main member.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: This invention is directed in part to novel doses, dosage formulations, and routes of administration of such doses and dose formulations, said dose and dose formulations containing one or more copper chelators, for example, one or more trientine active agents, including trientine analogues, trientine salts, trientine prodrugs, and trientine derivatives, useful in the treatment of diseases, disorders and conditions, including in indications where copper may play a role.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A flow control system for drilling a well comprises a conduit defining a channel configured to accommodate a drill pipe and a flow of a returning drilling fluid, and an acoustic sensor array configured to detect a flow rate of the returning drilling fluid. The flow control system further comprises a flow control device configured to control the flow rate of the returning drilling fluid and to be actuated in response to an event detected by the sensor array, the flow control device being proximate to the sensor array.

Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Blowout preventer systems are provided. According to an exemplary embodiment, the system includes a blowout preventer, a plurality of position sensing mechanisms, a plurality of pressure sensing mechanisms, and a controller configured to receive position data indicating a position of a piston and pressure data indicating the pressure of hydraulic fluid being applied to the piston, and to determine a current stroking pressure signature or fingerprint during a closing cycle, which when compared to a baseline stroking pressure signature or fingerprint, can provide an indication of the health of one or more components of the operator containing the piston. The controller can also determine a backlash of the ram block, and/or to record a position of the ram block, and/or to calculate an instant when a supplemental closing pressure is desired to be applied, and/or to determine when maintenance of a ram locking mechanism is due, and/or to determine when sealing elements are worn.

Abstract: A BOP system for use in a high pressure subsea environment, including a BOP stack including a lower marine riser package and a lower stack portion, the lower stack portion having a plurality of BOP rams attached to a subsea wellhead. The system also includes a riser subsystem extending from a drilling vessel to the BOP stack and providing fluid communication therebetween, a ship board subsystem electronically, mechanically, and hydraulically connected to the BOP stack and the riser subsystem to control the functions of the BOP stack and the riser subsystem, and a safety instrumented system having a surface logic solver and at least one subsea logic solver, the safety instrumented system in communication with at least a portion of the BOP rams to act as a redundant control system in case of failure of the ship board subsystem.

Abstract: In some embodiments, a rotor system for a rotorcraft includes a yoke, a blade, and a grip that is configured to couple the blade to the yoke. The grip has a plurality of baseline layers and a compliant layer. The baseline layers each have a plurality of fibers disposed in a first polymeric matrix. The compliant layer has a plurality of fibers disposed in a second polymeric matrix. The compliant layer is stronger than the baseline layer and the first polymeric matrix has a different chemical composition than the second polymeric matrix.

Abstract: A construction dust and debris collecting attachment device for a vacuum may include a shell with an interior housing. The shell may have a plurality of holes. The plurality of holes may a drill and arbor port, a vacuum port, and a plurality of dilution holes. A vacuum fitting may removably attach to the vacuum port on the shell. The shell may be a half spherical shape. When producing a hole, the device may allow one person to drill the hole while controlling the dust and debris within the shell, and in turn collected into the vacuum.

Abstract: Disclosed is a cover for a bottle that includes a retention feature to allow a user to hold the bottle using a single digit of the user's hand once the cover is in place. Preferably the cover is designed so that it can be slipped over a bottle containing e-liquid for refilling of electronic cigarettes. The cover is a form fitting sleeve and permits visualization of the fluid level in the bottle through openings in the sleeve or by using a semi-transparent material for the sleeve. The retention feature, preferably, can be shaped into a loop shape by the user and allows a user to slip at least one digit through the retention feature thereby permitting the user to simultaneously hold the bottle and a cartridge, cartomizer or clearomizer in one hand and to use the other hand to fill the cartridge, cartomizer or clearomizer of the electronic cigarette with the e-liquid.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.