Abstract: The present invention discloses novel tricyclic compounds represented by the formula (1.

Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 Also disclosed are novel compounds of the formulas: and Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.

Abstract: A novel wafer or circuit board automatic scanning optical inspection system and technique using the reference comparison principle for finding defects in scanned sample images, that enables a new degree of universality in finding all defects including very small single pixel conductor breaks and shorts and defects of irregular shapes, and together with simultaneous design rule processing, through the use of processed skeletal reference images and with separately programmable alignment tolerance and detection parameters.

Abstract: Regulatory nucleotide sequences for a novel Pichia pastoris gene, designated PpSEC10 gene, and the nucleotide sequences and respective amino acid sequences for the secretion leader and the mature Sec10p protein components of the precursor polypeptide encoded by this novel gene are provided. These compositions are useful in methods for expression and secretion of proteins when assembled in proper reading frame, individually or in combination, within a DNA construct that further comprises a nucleotide sequence encoding a protein of interest. Vectors comprising the DNA constructs of the invention can be used to transform a yeast host cell, which can then be cultured to obtain the secreted protein of interest. Kits useful in this method and in methods of detection of the Sec10p protein using antibodies are also disclosed.

Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.

Abstract: A perspiration shield takes the form of a multi-layered sheet that is shaped and sized to be placed between adjacent or opposing skin surfaces, such as under the breast, to prevent and absorb perspiration. The multi-layered sheet has an absorbent layer forming one surface of the shield and a silicone gel layer forming another surface of the shield. The silicone gel layer has a soft, tacky texture and readily adheres to the skin but leaves no perceptible residue on the skin when removed. The silicone gel layer closes the pores of the skin with which the layer is in contact, thereby reducing or preventing perspiration from these pores. The absorbent layer absorbs perspiration from the pores of the skin adjacent and opposing the skin surface to which the silicon gel layer is attached and is formed of a material that readily absorbs moisture.

Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 Also disclosed are novel compounds of the formulas: Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.

Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 5.1 and 5.2 are disclosed.

Abstract: Semiconductor wafers, circuit boards and similar multi-layer structures are optically inspected at high speeds with the aid of preferably a pair of oppositely and inclinedly directed laser beams at inclined angles to the vertical and the wafer surface to cause fluorescence by a photoresist layer carrying conductor patterns, defects in which are to be inspected, and using preferably a time-delay-integration CCD imaging camera for recording a fluorescent resist surface image accentuating the non-fluorescing conductor pattern thereupon, while masking all light from layers therebelow.

Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 ##STR1## Also disclosed are novel compounds of the formulas: ##STR2## Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3.Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.

Abstract: A fully automated protein and/or DNA gene fragment analyzing machine and method are disclosed in which, in a simple machine structure, a plurality of electrophoresis calls each containing such fragments, are robotically, under computer programming, inserted into an electrophoresis housing and subjected to voltage for producing electrophoretic migration in one dimension (horizontally), and then preferably after robotic 90.degree. rotating of the cells, are voltage migrated in an orthogonal direction to separate the fragments vertically, and then robotically presented to an optical image scanner for identifying the brightest fragments and classifying the same, with comparison with reference image fragment locations of normal or variant fragments, and for computer storing all relevant data.

Abstract: A novel optical inspection technique for multi-layer wafers and the like in which conductor patterns of a top layer only are to be inspected, such layer being upon an intermediate transparent or translucent insulation layer in turn upon a base layer(s) thereunder, wherein the intermediate layer only is fluoresced, displaying the top layer conductors as dark in the field of fluorescent light, and causing reflections from layers below the intermediate layer effectively to disappear to obviate confusion with the top layer conductors to be inspected.

Abstract: The invention encompasses a semi-automatic and/or automatic computer-aided technique for designing comprehensive DNA diagnostic tests for mutations in disease genes through searching for optimized conditions for PCR amplification and for optimal melting behavior in denaturing gradient gels and for optimal distribution in two-dimensional electrophoresis display of the mutational target fragments.

Abstract: A temperature controlled cabinet system and method enables medical items associated with particular temperature ranges to be stored and maintained within their associated temperature ranges in cabinets disposed within ambulances and other medical vehicles. The system includes a temperature sensor for measuring the cabinet interior temperature, a controller assembly for controlling system operation and two heat pumps disposed in the cabinet walls to heat or cool the cabinet interior. Alternatively, a single heat pump may be utilized to heat or cool the cabinet interior. The controller assembly includes a control console for displaying the actual cabinet temperature and entering a desired temperature range into the system. The heat pumps include a pair of heat sinks disposed about a thermoelectric device (e.g., a Peltier chip) that heats one heat sink, while cooling the other heat sink based on voltage polarity or current flow direction applied to the device.

Abstract: An energy dissipating assembly for flowing water is provided which consists of a plurality of modules, each one of the modules being a buoyant body consisting of a continuous envelope defining a hollow watertight chamber, the envelope having a plurality of intersecting planar surfaces and an attaching members connected to at least two spaced locations on the continuous envelope to attach the buoyant body in a three dimensional relationship. Parts are also provided to adjust the buoyancy and mass of the buoyant body so that the assembly can be tuned for the wave activity of the water in which the system is disposed. A method of disrupting the wave action is also provided.

Abstract: A fully automated protein and/or DNA gene fragment analyzing machine and method are disclosed in which, in a simple machine structure, a plurality of electrophoresis cells each containing such fragments, are robotically, under computer programming, inserted into an electrophoresis housing and subjected to voltage for producing electrophoretic migration in one dimension (horizontally), and then preferably after robotic 90.degree. rotating of the cells, are voltage migrated in an orthogonal direction to separate the fragments vertically, and then robotically presented to an optical image scanner for identifying the brightest fragments and classifying the same, with comparison with reference image fragment locations of normal or variant fragments, and for computer storing all relevant data.

Abstract: A variable output inflator (20) for use in inflating an air bag or air cushion comprising: a pressure vessel (22) comprising a thin walled toroidal pressure vessel portion (23) and a cylindrical pressure vessel portion (60) circumscribed by, in physical contact and in fluid communication with the toroidal pressure vessel portion, the cylindrical pressure vessel portion including a rupturable disk (74) and at least one exit port (78) communicable with an air bag; a pyrotechnic member (200a,b) for heating stored inflation gas within the pressure vessel to a pressure level to rupture the rupturable disk, allowing heated inflation gas to exit and fill an adjacently attached air bag.

Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: ##STR1## to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulas 5.0, 5.1 and 5.2, wherein R is --C(R.sup.20)(R.sup.21)(R.sup.46), and 5.3, 5.3A and 5.3B, wherein R is --N(R.sup.25)(R.sup.48), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.

Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula. 1.0 ##STR1## Also disclosed are novel compounds of the formulas: ##STR2## Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3.Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.