Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: One or more packing systems and/or methods of manufacture are disclosed for a valve seal with lowered emissions while being complaint with fire standards. The packing system may have alternating mid-layers, a top layer, a bottom layer, and a first end cap and a second end cap. The layers can be formed of a flexible graphite-based material and/or a perfluoroalkoxy alkane (PFA) material. The layers may be bonded together and expand under compression to form a seal between a valve stem and a stuffing box.

Abstract: Provided are systems and methods for vessel risk assessment. This includes determining a risk assessment associated with a vessel, including receiving vessel data from at least one source, generating at least one vessel profile based on the vessel data, wherein each vessel profile provides indication of expected behavior events for one vessel and abnormal behavior events for one vessel, determining at least one abnormal behavior event of the vessel based on the at least one vessel profile, each event in the at least one abnormal behavior event having a time of occurrence, determining at least one frequency of occurrence of abnormal behavior events of the vessel based on the time of occurrence of each event, using at least one model to determine a risk assessment associated with the vessel based on the at least one frequency of occurrence of abnormal behavior events of the vessel.

Abstract: A vehicle is provided that includes a basic structure; and coupled to the basic structure, power sources, a propulsion system and power distribution circuitry. The propulsion system includes a plurality of electric motors configured to power propulsors to generate propulsive forces that cause the vehicle to move. The power distribution circuitry is configured to deliver DC electric power from the power sources to the electric motors, the power distribution circuitry including a plurality of DC-to-DC converter assemblies configured to input the DC electric power from the power sources and deliver voltage-regulated outputs to the electric motors, a DC-to-DC converter assembly operatively coupled to multiple ones of the power sources and multiple ones of the electric motors, and the DC-to-DC converter assembly including a multiple-input and multiple-output (MIMO) transformer with a single transformer core.

Abstract: An electronic device may use information about the location of nearby devices to make sharing with those devices more intuitive for a user. The electronic device may include control circuitry, wireless circuitry including first and second antennas, and motion sensor circuitry. The control circuitry may determine the location of a nearby electronic device by calculating the angle of arrival of signals that are transmitted by the nearby electronic device. To obtain a complete, unambiguous angle of arrival solution, the electronic device may be moved into different positions during angle of arrival measurement operations. At each position, the control circuitry may calculate a phase difference associated with the received signals. Motion sensor circuitry may gather motion data as the electronic device is moved into the different positions. The control circuitry may use the received antenna signals and the motion data to determine the complete angle of arrival solution.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, Y, R1-R8, m, n and p are defined herein. The novel cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

Abstract: In this patent disclosure, various embodiments of using near-field communication (NFC) to facilitate secure data exchange between a robotic surgical system and a surgical tool attached onto the robotic surgical system are disclosed. In one aspect, a process for enabling secure data exchange between a robotic surgical system and a surgical tool begins by detecting a coupling of the surgical tool onto the robotic surgical system. The process next establishes a NFC link between a first NFC module embedded in the robotic surgical system and a second NFC module embedded in the surgical tool. The process then determines whether the surgical tool is authenticated to the robotic surgical system via the NFC link. Next, in response to the authentication of the surgical tool, the process establishes secure data exchange between the robotic surgical system and the surgical tool.

Abstract: The invention disclosed is a tool for the removal of knock-outs from electrical boxes. The tool may include a handle connected to an elongate member such as a rod, the elongate member having a bend between the handle and a termina end that is bent back or forms a hook. The terminal end may include a flattened end and a slot opened at the end to allow the user to engage the edge of a knock-out. The tool may also include a groove in the radius or bend of the hook, also to allow the user to engage the edge of a knock-out. The tool also includes notches on the elongate member to allow the user to engage the edge of a an electrical box to manipulate or rotate the tool about the engagement to dislodge or displace the knock-out from the electrical box with the tip of the terminal end.

Abstract: Novel bean plants, such as bean designated HMC016335 are disclosed. In some embodiments, the disclosure relates to the seeds of bean plant HMC016335, to the plants and plant parts of bean HMC016335, and to methods for producing a bean plant by crossing the bean plant HMC016335 with itself or another bean plant. The disclosure further relates to methods for producing other bean plants derived from the bean HMC016335.

Abstract: Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

Abstract: A system for controlling vehicle motion is described. The system includes: a first set of sensors coupled with a vehicle, the first set of sensors configured for sensing the vehicle motion; and a vehicle suspension damper coupled with the first set of sensors, the vehicle suspension damper configured for adjusting a damping force therein, the vehicle suspension damper comprising: a primary valve; a pilot valve assembly coupled with the primary valve, the pilot valve assembly configured for metering a flow of fluid to the primary valve, in response to at least the sensing; and an orifice block coupled with the primary valve and comprising a control orifice there through, the control orifice configured for operating cooperatively with the pilot valve assembly in the metering the flow of fluid to the primary valve.

Abstract: A system for guiding an industrial truck in a high-bay store comprising a plurality of bay posts, the system including a sensor unit configured to record vehicle position data that represent a relative or absolute current position of the truck. The system includes a bay post determination unit configured to determine at least one bay post that is to be expected in an event of further travel of the truck and bay post position data that represent a relative or absolute position of the at least one bay post. The system includes a computing unit configured to communicate with the sensor unit and with the bay post determination unit and to calculate a desired travel route of the truck based on the vehicle position data and the bay post position data. The system includes a control unit configured to guide the truck based on the desired travel route.

Abstract: A computer implemented method of feature detection in temporal graph data structures of events, the method including receiving a temporal series of graph data structures of events each including a plurality of nodes corresponding to events and edges connecting nodes corresponding to relationships between events; rendering each graph data structure in the series as an image representation of the graph data structure including a representation of nodes and edges in the graph being rendered reproducibly in a cartesian space based on attributes of the nodes and edges, so as to generate a temporal series of image representations ordered according to the temporal graph data structures; processing the series of image representations by a convolutional neural network to classify the image series so as to identify a feature in the image series, the convolutional neural network being trained by a supervised training method including a plurality of training example image series in which a subset of the training examples

Abstract: Novel bean plants, such as bean designated BASS are disclosed. In some embodiments, the disclosure relates to the seeds of bean plant BASS, to the plants and plant parts of bean BASS, and to methods for producing a bean plant by crossing the bean plant BASS with itself or another bean plant. The disclosure further relates to methods for producing other bean plants derived from the bean BASS.

Abstract: Embodiments of golf club heads and methods to manufacture golf club heads are generally described herein. In one example, a golf club head may include a body portion with an interior cavity, an upper back wall portion, a lower back wall portion, a ledge portion extending from the upper back wall portion to the lower back wall portion, an upper back wall portion thickness, and a lower back wall portion thickness. The golf club head may further include a first mass portion below the ledge portion, a second mass portion above the ledge portion, a polymer material in the interior cavity, a first width of the interior cavity above the ledge portion, a second width of the interior cavity below the ledge portion and above the lower back wall portion thickness, and a third width of the interior cavity below the second width.

Abstract: A crash box (3) comprising a hollow profile (38) extending along a longitudinal direction (X) and having a crush length (LCB), said hollow profile (38) having at least two chambers (4) characterized in that it comprises at least a deformable element (7, 7?, 7?) contained into at least one chamber (4) contributing to the energy absorption capability of said crash box (3).

Abstract: A computing device may receive motion data generated by one or more motion sensors that correspond to movement sensed by the one or more motion sensors. The computing device may perform, using one or more neural networks trained with differential privacy, on-device activity recognition to recognize a physical activity that corresponds to the motion data. The computing device may, in response to recognizing the physical activity that corresponds to the motion data, perform an operation associated with the physical activity.

Abstract: A method for producing an image of a subject with a magnetic resonance imaging (MRI) comprises acquiring a first set of partial k-space data from the subject and generating a phase corrected image based on a phase correction factor and the first set of the partial k-space data. The method further includes transforming the phase corrected image into a second set of partial k-space data and reconstructing the image of the subject from the second set of the partial k-space data and a weighting function.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: Systems are provided for a cable hangers. A system for cable hangers can include a cable hanger having a support member including a proximal end and a distal end. A plurality of saddles are attached to and extend from the support member, with each saddle of the plurality of saddles being configured to support at least one cable on a cable supporting surface A hanging mechanism is arranged at the proximal end of the support member, where the hanging mechanism is offset on the support member.