Patents by Inventor Robert G. Johnson

Robert G. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THERAPEUTIC OR VACCINE DELIVERY
    Publication number: 20230277647
    Abstract: Described herein are compositions for delivering a therapeutic or vaccine. Also described herein are methods for using the compositions described herein for delivering a therapeutic or a vaccine.
    Type: Application
    Filed: October 24, 2022
    Publication date: September 7, 2023
    Inventors: Jacqueline FISCHER-LOUGHEED, Bradford H. STEELE, Cecilia ROH, Robert G. JOHNSON
  • COMPOSITIONS AND METHODS FOR THERAPEUTIC DELIVERY
    Publication number: 20230265457
    Abstract: Described herein are compositions for delivering a therapeutic. Also described herein are methods of using the compositions described herein for delivering a therapeutic.
    Type: Application
    Filed: October 24, 2022
    Publication date: August 24, 2023
    Inventors: Brile CHUNG, Cecilia ROH, Robert G. JOHNSON
  • THYMIDINE KINASE GENE
    Publication number: 20220401581
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: June 17, 2022
    Publication date: December 22, 2022
    Inventors: John P. LEVY, Rebecca A. REED, Joseph McNULTY, Robert G. JOHNSON, JR.
  • Thymidine kinase gene
    Patent number: 11364307
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: June 21, 2022
    Assignee: GENVIVO, INC.
    Inventors: John P. Levy, Rebecca A Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • Thymidine kinase diagnostic assay for gene therapy applications
    Patent number: 11253611
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: February 22, 2022
    Assignee: GENVIVO, INC.
    Inventors: John P. Levy, Rebecca A. Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • THYMIDINE KINASE GENE
    Publication number: 20200179533
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: February 21, 2020
    Publication date: June 11, 2020
    Inventors: John P. LEVY, Rebecca A. REED, Joseph McNULTY, Robert G. JOHNSON
  • Thymidine kinase gene
    Patent number: 10610603
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: April 7, 2020
    Assignee: GenVivo, Inc.
    Inventors: John P. Levy, Rebecca A. Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • THYMIDINE KINASE DIAGNOSTIC ASSAY FOR GENE THERAPY APPLICATIONS
    Publication number: 20190328904
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Inventors: John P. LEVY, Rebecca A. REED, Joseph MCNULTY, Robert G. JOHNSON, Jr.
  • Thymidine kinase diagnostic assay for gene therapy applications
    Patent number: 10350302
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 16, 2019
    Assignee: GenVivo, Inc.
    Inventors: John P. Levy, Rebecca A. Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • THYMIDINE KINASE DIAGNOSTIC ASSAY FOR GENE THERAPY APPLICATIONS
    Publication number: 20180264137
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: May 31, 2018
    Publication date: September 20, 2018
    Inventors: John P. LEVY, Rebecca A. REED, Joseph MCNULTY, Robert G. JOHNSON, JR.
  • THYMIDINE KINASE GENE
    Publication number: 20180236101
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: February 8, 2018
    Publication date: August 23, 2018
    Inventors: John P. LEVY, Rebecca A. REED, Joseph McNULTY, Robert G. JOHNSON, Jr.
  • Method for identifying and treating a patient having tumor lesions comprising administering a gene therapy retroviral vector particle comprising a mutated HSV-thymidine kinase (HSV-TK) polynucleotide
    Patent number: 9999683
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 19, 2018
    Assignee: EPEIUS BIOTECHNOLOGIES CORPORATION
    Inventors: John P. Levy, Rebecca A. Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • Thymidine kinase gene
    Patent number: 9925276
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 27, 2018
    Assignee: EPEIUS BIOTECHNOLOGIES CORPORATION
    Inventors: John P. Levy, Rebecca A. Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • Portable unit for treating chronic pain
    Patent number: 9186506
    Abstract: A portable pain treatment unit includes: a first pulse generator configured to deliver pulses in a frequency range typical for interferential treatment; a second pulse generator configured to deliver pulses in the frequency range for transcutaneous electrical nerve stimulator (TENS) treatment; electrodes operatively connected with the first and second pulse generators that are configured for application to a treatment area; and a power source operatively connected to the first and second pulse generators. A device of this configuration enables the patient to receive either IF or TENS treatment at a location of his/her choosing rather than being forced to receive IF treatment in a clinical setting.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: November 17, 2015
    Assignee: MEDFAXX, INC.
    Inventor: Robert G. Johnson
  • THYMIDINE KINASE DIAGNOSTIC ASSAY FOR GENE THERAPY APPLICATIONS
    Publication number: 20140294772
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 2, 2014
    Applicant: Epeius Biotechnologies Corporation
    Inventors: John P. LEVY, Rebecca A. REED, Joseph MCNULTY, Robert G. JOHNSON, JR.
  • THYMIDINE KINASE GENE
    Publication number: 20140288163
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Inventors: John P. LEVY, Rebecca A. REED, Joseph MCNULTY, Robert G. JOHNSON, JR.
  • Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either
    Patent number: 7691392
    Abstract: A method for treating multiple myeloma in a subject by administering 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a prodrug of either 17-AAG or 17-AG, to the subject.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: April 6, 2010
    Assignee: Kosan Biosciences Incorporated
    Inventors: Robert G. Johnson, Jr., Alison L. Hannah, Gillian F. Cropp, Yiqing Zhou, J. Michael Sherrill
  • Portable Unit for Treating Chronic Pain
    Publication number: 20080167697
    Abstract: A portable pain treatment unit includes: a first pulse generator configured to deliver pulses in a frequency range typical for interferential treatment; a second pulse generator configured to deliver pulses in the frequency range for transcutaneous electrical nerve stimulator (TENS) treatment; electrodes operatively connected with the first and second pulse generators that are configured for application to a treatment area; and a power source operatively connected to the first and second pulse generators. A device of this configuration enables the patient to receive either IF or TENS treatment at a location of his/her choosing rather than being forced to receive IF treatment in a clinical setting.
    Type: Application
    Filed: March 18, 2008
    Publication date: July 10, 2008
    Inventor: Robert G. Johnson
  • Therapeutic formulations
    Patent number: 7091193
    Abstract: Formulations comprising one or more epothilones together with a pharmaceutically acceptable carrier, in particular such pharmaceutical compositions suitable for oral administration of an epothilone.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: August 15, 2006
    Assignee: Kosan biosciences Incorporated
    Inventors: Michael J. Sherrill, Robert G. Johnson, Jr.
  • EPO D + 5-FU/gemcitabine
    Publication number: 20040167097
    Abstract: Methods and compositions for treating hyperproliferative diseases using combinations of one or more epothilones and one or more nucleoside analogs. In some embodiments, the combination includes epothilone D and 5-fluorouracil or 5′-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine.
    Type: Application
    Filed: May 3, 2004
    Publication date: August 26, 2004
    Inventors: Yiqing Zhou, Robert G. Johnson