Patents by Inventor Robert H. Grubbs

Robert H. Grubbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for modifying power of light adjustable lens
    Patent number: 9950482
    Abstract: A method for adjusting a light adjustable lens in an optical system includes providing a light adjustable lens in an optical system; providing an ultraviolet light source to generate an ultraviolet light; and irradiating the generated ultraviolet light with a light delivery system onto the light adjustable lens with a center wavelength and with a spatial irradiance profile to change a dioptric power of the light adjustable lens by changing a refraction of the light adjustable lens in a refraction-change zone, thereby causing a wavefront sag, defined as half of a product of the change of the dioptric power and the square of a radius of the refraction-change zone, to be within 10% of its maximum over an ultraviolet spectrum.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: April 24, 2018
    Assignee: RxSight, Inc.
    Inventors: Robert H. Grubbs, Christian A. Sandstedt
  • BACKFUNCTIONALIZED IMIDAZOLINIUM SALTS AND NHC CARBENE-METAL COMPLEXES
    Publication number: 20180072681
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
    Type: Application
    Filed: October 5, 2017
    Publication date: March 15, 2018
    Applicant: Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Rusty L. Blanski, Robert H. Grubbs
  • DNA-FUNCTIONALIZED SCAFFOLDS FOR DRUG CAPTURE APPLICATIONS
    Publication number: 20180064747
    Abstract: This disclosure is directed to structured compositions, including DNA-functionalized scaffolds, for drug capture, and methods and devices for sequestering chemotherapeutics from physiological fluids using the functionalized scaffolds.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 8, 2018
    Inventors: MICHAEL D. SCHULZ, CARL M. BLUMENFELD, ROBERT H. GRUBBS, JULIA R. GREER, DARYL WEI LIANG YEE
  • Reactions of aromatic substrates with base-activated hydrosilanes-silylations and reductive cleavage
    Patent number: 9908840
    Abstract: The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: March 6, 2018
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Alexey Fedorov, Anton Toutov, Nicholas A. Swisher
  • SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS
    Publication number: 20180057514
    Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
    Type: Application
    Filed: November 6, 2017
    Publication date: March 1, 2018
    Inventors: ANTON TOUTOV, KERRY BETZ, ALEXEY FEDOROV, BRIAN M. STOLTZ, WENBO LIU, ROBERT H. GRUBBS
  • Light adjustable intraocular lenses using upconverting nanoparticles and near infrared (NIR) light
    Patent number: 9895467
    Abstract: This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. Other methods improve the mechanical strength of the sclera directly.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: February 20, 2018
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Shane L. Mangold
  • Functionalized linear and cyclic polyolefins
    Patent number: 9890239
    Abstract: This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. Polymer products produced via the olefin metathesis reactions of the invention may be utilized for a wide range of materials applications. The invention has utility in the fields of polymer and materials chemistry and manufacture.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: February 13, 2018
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Robert Tuba, Robert H. Grubbs
  • Backfunctionalized imidazolinium salts and NHC carbene-metal complexes
    Patent number: 9828347
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 28, 2017
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Rusty L Blanski, Robert H Grubbs
  • Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts
    Patent number: 9809607
    Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: November 7, 2017
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • ANION-COORDINATING POLYMER ELECTROLYTES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20170275399
    Abstract: Anion-coordinating polymers comprising one or more anion-coordinating unit of Formula (I), optionally in combination with one or more cation-coordinating unit of Formula (II) and/or a linking unit of Formula (III) and related electrolytes, batteries, methods and system.
    Type: Application
    Filed: January 4, 2017
    Publication date: September 28, 2017
    Inventors: Brett M. SAVOIE, Michael A. WEBB, Robert H. GRUBBS, Thomas F. MILLER, III, Geoffrey W. COATES, Qi ZHENG
  • Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts
    Patent number: 9764995
    Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates using at least alkoxide base, preferably a potassium alkoxide base and at least one organodisilane and (b) at least one alkoxide base. Both methods and compositions for affecting these transformations are disclosed.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 19, 2017
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Wenbo Liu, Brian M. Stoltz, Robert H. Grubbs, Kerry Betz, David P. Schuman
  • BACKFUNCTIONALIZED IMIDAZOLINIUM SALTS AND NHC CARBENE-METAL COMPLEXES
    Publication number: 20170247333
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
    Type: Application
    Filed: May 16, 2017
    Publication date: August 31, 2017
    Applicant: Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Rusty L. Blanski, Robert H. Grubbs
  • STABLE SILYLATING REAGENTS
    Publication number: 20170240571
    Abstract: The present invention is directed to compositions for silylating organic substrates containing C—H or O—H bonds, especially heteroaromatic substrates. The compositions are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide and metal alkoxide bases. In some embodiments, the preconditioning results in the formation of reactive silicon hydride species.
    Type: Application
    Filed: February 22, 2017
    Publication date: August 24, 2017
    Inventors: ANTON TOUTOV, WENBO LIU, DAVID P. SCHUMAN, BRIAN M. STOLTZ, ROBERT H. GRUBBS H. GRUBBS
  • Catalysts for (E)-selective olefin metathesis
    Patent number: 9701704
    Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: July 11, 2017
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Choon Woo Lee, Robert H. Grubbs, Pablo E. Guzman, Tonia S. Ahmed, T. Patrick Montgomery
  • PHOTOACTIVATED MOLECULES FOR LIGHT INDUCED MODULATION OF THE ACTIVITY OF ELECTRICALLY EXCITABLE CELLS AND METHODS OF USING THE SAME
    Publication number: 20170189530
    Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.
    Type: Application
    Filed: August 18, 2016
    Publication date: July 6, 2017
    Inventors: Melanie A. Yen, Dennis A. Dougherty, Robert H. Grubbs, Harry B. Gray, Robert H. Chow, Mark S. Humayun, Mark Thompson, Oliver Shafaat, Erin Lamb
  • Selective olefin metathesis with cyclometalated ruthenium complexes
    Patent number: 9676676
    Abstract: This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 13, 2017
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: John Hartung, Jr., Brendan L. Quigley, Peter K. Dornan, Robert H. Grubbs
  • Caged compound delivery and related compositions, methods and systems
    Patent number: 9636656
    Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: May 2, 2017
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, University of Southern California
    Inventors: Dennis A. Dougherty, Robert H. Grubbs, Mark Humayun, Clinton J. Regan, Azita Emami
  • Sulfonic esters of metal oxides and methods of their use
    Patent number: 9636428
    Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: May 2, 2017
    Assignees: California Institute of Technology, Children's Hospital of Los Angeles
    Inventors: Carl M. Blumenfeld, Karn Sorasaenee, Harry B. Gray, Robert H. Grubbs
  • DERIVATIZED CORROLES AND METALLOCORROLES AND THEIR USE AS IMAGING AND THERAPEUTIC AGENTS
    Publication number: 20170096434
    Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.
    Type: Application
    Filed: October 6, 2016
    Publication date: April 6, 2017
    Inventors: MELANIE A. YEN, HARRY B. GRAY, ROBERT H. GRUBBS, JOSHUA Palmer
  • SILYLATION OF AROMATIC HETEROCYCLES BY DISILANES USING POTASSIUM ALKOXIDE CATALYSTS
    Publication number: 20170088562
    Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates using at least alkoxide base, preferably a potassium alkoxide base and at least one organodisilane and (b) at least one alkoxide base. Both methods and compositions for affecting these transformations are disclosed.
    Type: Application
    Filed: December 12, 2016
    Publication date: March 30, 2017
    Inventors: ANTON TOUTOV, WENBO LIU, BRIAN M. STOLTZ, ROBERT H. GRUBBS, KERRY BETZ, DAVID P. SCHUMAN