Patents by Inventor Robert H. Grubbs

Robert H. Grubbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170022231
    Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Application
    Filed: March 18, 2016
    Publication date: January 26, 2017
    Inventors: Choon Woo LEE, Robert H. GRUBBS, Pablo E. GUZMAN, Tonia S. AHMED, T. Patrick MONTGOMERY
  • Publication number: 20170020658
    Abstract: The invention relates to novel optical elements having improved UV protection. The optical element comprises a light adjustable optical element with a UV absorbent layer applied to at least one surface of the optical element. The invention is particularly useful in light adjustable intraocular lenses.
    Type: Application
    Filed: July 20, 2015
    Publication date: January 26, 2017
    Applicant: Calhoun Vision, Inc,
    Inventors: Robert H. Grubbs, Shiao H. Chang
  • Publication number: 20170018801
    Abstract: Provided herein are copolymer electrolytes and electrocatalyst platforms, including brush block copolymers, triblock brush copolymers and pentablock brush copolymers. The copolymers described have beneficial chemical, physical and electrical properties including high ionic conductivity and mechanical strength. In embodiments, for example, the provided copolymer electrolytes and electrocatalyst platforms are doped with lithium salts or mixed with ionic liquids to form ion gels. In some embodiments, the copolymers provided herein self-assemble into physically cross-linked polymer networks with additional useful properties. The provided copolymers have low dispersity in the polymer side chains and do not require post-polymerization modifications.
    Type: Application
    Filed: March 9, 2016
    Publication date: January 19, 2017
    Inventors: Robert H. GRUBBS, Christopher M. BATES, Alice CHANG, Brendon MCNICHOLAS, Simon C. JONES
  • Patent number: 9533928
    Abstract: The disclosure provides a dual-catalysis system for direct conversion of olefins to alcohols. The cooperative catalytic system contains one oxidizing catalyst and one transfer-hydrogenation catalyst. A wide variety of olefins, including aromatic and aliphatic olefins, can be used as the reactant. The transformation proceeds with anti-Markovnikov selectivity, and in some aspects provides primary alcohols as major products. The disclosure further provides a system for oxidation of olefins with anti-Markovnikov selectivity.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: January 3, 2017
    Assignee: California Institute of Technology
    Inventors: Guangbin Dong, Robert H. Grubbs, Peili Teo, Zachary K. Wickens
  • Publication number: 20160367669
    Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
    Type: Application
    Filed: June 30, 2016
    Publication date: December 22, 2016
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
  • Publication number: 20160356923
    Abstract: The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary structure. The invention also provides structures generated by self-assembly of polymer blends including at least one block copolymer component, such as a brush block polymer or wedge-type block polymer. The invention provides, for example, periodic nanostructures and microstructures generated by self-assembly of block copolymers and polymer blends comprising a mixture of at least one block copolymer component, such as a brush block copolymer, and at least a second component.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Applicant: California Institute of Technology
    Inventors: Garret M. MIYAKE, Raymond WEITEKAMP, Robert H. GRUBBS, Victoria PIUNOVA
  • Publication number: 20160347776
    Abstract: The present invention is directed to a mild, efficient, and general direct C(sp2)-H bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal olefinic C—H bond, with a mixture of at least one organosilane, organosilane, or mixture thereof and an alkali metal alkoxide or alkali metal hydroxide, such that the contacting results in the formation of a silylated olefinic product. The systems associated with these methods are also disclosed.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 1, 2016
    Inventors: ANTON TOUTOV, WENBO LIU, KERRY BETZ, ALEXEY FEDOROV, BRIAN M. STOLTZ, ROBERT H. GRUBBS
  • Publication number: 20160339657
    Abstract: A method for adjusting a light adjustable lens in an optical system includes providing a light adjustable lens in an optical system; providing an ultraviolet light source to generate an ultraviolet light; and irradiating the generated ultraviolet light with a light delivery system onto the light adjustable lens with a center wavelength and with a spatial irradiance profile to change a dioptric power of the light adjustable lens by changing a refraction of the light adjustable lens in a refraction-change zone, thereby causing a wavefront sag, defined as half of a product of the change of the dioptric power and the square of a radius of the refraction-change zone, to be within 10% of its maximum over an ultraviolet spectrum.
    Type: Application
    Filed: May 20, 2016
    Publication date: November 24, 2016
    Applicant: Calhoun Vision, Inc.
    Inventors: Robert H. Grubbs, Christian A. Sandstedt
  • Publication number: 20160331868
    Abstract: This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. Other methods improve the mechanical strength of the sclera directly.
    Type: Application
    Filed: May 13, 2016
    Publication date: November 17, 2016
    Inventors: ROBERT H. GRUBBS, SHANE L. MANGOLD
  • Publication number: 20160289392
    Abstract: Provided herein is a class of copolymers, including triblock brush copolymers having specific block configurations, for example, ABC triblock brush copolymers and ABA triblock brush copolymers. In an embodiment, for example, copolymers of the invention incorporate various polymer side chain groups which contribute beneficial physical, chemical, or electronic properties such as increased mechanical or elastic strength, improved ionic or electric conductivity. In some embodiments, the provided copolymers exhibit advantageous steric properties allowing for rapid self-assembly into a variety of morphologies that are substantially different than non-brush, block copolymers.
    Type: Application
    Filed: March 9, 2016
    Publication date: October 6, 2016
    Inventors: Robert H. GRUBBS, Christopher M. BATES, Alice CHANG, Brendon MCNICHOLAS, Simon C. JONES
  • Patent number: 9453943
    Abstract: The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary structure. The invention also provides structures generated by self-assembly of polymer blends including at least one block copolymer component, such as a brush block polymer or wedge-type block polymer. The invention provides, for example, periodic nanostructures and microstructures generated by self-assembly of block copolymers and polymer blends comprising a mixture of at least one block copolymer component, such as a brush block copolymer, and at least a second component.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: September 27, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Garret M Miyake, Raymond Weitekamp, Robert H Grubbs, Victoria Piunova
  • Patent number: 9440891
    Abstract: The present invention is directed to methods of forming olefins, especially linear alpha olefins from fatty acids or anhydrides, each method comprising: contacting an amount of precursor carboxylic acid anhydride with a palladium catalyst comprising a bidentate bis-phosphine ligand in a reaction mixture so as to form an olefin in a product with the concomittant formation and removal of CO and water from the reaction mixture, either directly or indirectly, wherein the reaction mixture is maintained with a sub-stoichiometric excess of a sacrificial carboxylic acid anhydride, an organic acid, or both, said sub-stoichiometric excess being relative to the amount of the precursor carboxylic acid anhydride. The precursor carboxylic acid anhydride may be added to the reaction mixture directly or formed in situ by the reaction between at least one precursor carboxylic acid with a stoichiometric amount of the sacrificial acid anhydride.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 13, 2016
    Assignee: California Institute of Technology
    Inventors: Yiyang Liu, Brian M. Stoltz, Robert H. Grubbs, Alexey Fedorov, Kelly E. Kim
  • Publication number: 20160256081
    Abstract: A position sensing apparatus includes a position sensor, a voltage/current detector, and an alarm. The position sensor is coupled to the body part and includes a capsule, and first and second electrodes. The capsule has an interior volume configured to contain a liquid with a first density, and a contact member having a second density different from the first density. The first and second electrodes are fixed to the capsule to define a sensor meridian that is coupled to a tilt angle of the body part, with each electrode having a distal portion in the interior volume of the capsule, and the distal portions being configured to form a circuit with the liquid or the contact member. The voltage/current detector is configured to detect a change in a state of the circuit, and the alarm is configured to respond to the voltage/current detector.
    Type: Application
    Filed: March 4, 2016
    Publication date: September 8, 2016
    Inventors: Hyuck Choo, Frank L. Brodie, Robert H. Grubbs
  • Patent number: 9421164
    Abstract: The present inventions are directed to novel aqueous compositions comprising a copolymer having water-soluble units and pendant catechols, said composition adapted for use on mammalian tissue and having a lower critical solubility temperature (LCST) of less than a physiological temperature, and their use, for example, in removing foreign particles from tissue surfaces, including ocular surfaces.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: August 23, 2016
    Assignee: California Institute of Technology
    Inventors: Hoyong Chung, Robert H. Grubbs, Daniel M. Schwartz
  • Publication number: 20160237101
    Abstract: The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same.
    Type: Application
    Filed: August 15, 2014
    Publication date: August 18, 2016
    Inventors: Robert H. GRUBBS, Matthias SCHOLL
  • Patent number: 9403854
    Abstract: The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: August 2, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Robert H. Grubbs, Arnab K. Chatterjee, Tae-Lim Choi, Steven D. Goldberg, Jennifer A. Love, John P. Morgan, Daniel P. Sanders, Matthias Scholl, F. Dean Toste, Tina M. Trnka
  • Publication number: 20160215089
    Abstract: This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. Polymer products produced via the olefin metathesis reactions of the invention may be utilized for a wide range of materials applications. The invention has utility in the fields of polymer and materials chemistry and manufacture.
    Type: Application
    Filed: September 4, 2014
    Publication date: July 28, 2016
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Robert TUBA, Robert H. GRUBBS
  • Patent number: 9382387
    Abstract: The invention provides a class of copolymers having useful properties, including brush block copolymers, wedge-type block copolymers and hybrid wedge and polymer block copolymers. In an embodiment, for example, block copolymers of the invention incorporate chemically different blocks comprising polymer size chain groups and/or wedge groups that significantly inhibit chain entanglement, thereby enhancing molecular self-assembly processes for generating a range of supramolecular structures, such as periodic nanostructures and microstructures. The present invention also provides useful methods of making and using copolymers, including block copolymers.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: July 5, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Yan Xia, Benjamin R Sveinbjornsson, Robert H Grubbs, Raymond Weitekamp, Garret M Miyake, Harry A Atwater, Victoria Piunova, Christopher Scot Daeffler, Sung Woo Hong, Weiyin Gu, Thomas P. Russell
  • Publication number: 20160185684
    Abstract: This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Application
    Filed: July 1, 2015
    Publication date: June 30, 2016
    Inventors: John HARTUNG, JR., Brendan L. QUIGLEY, Peter K. DORNAN, Robert H. GRUBBS
  • Publication number: 20160185821
    Abstract: The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Application
    Filed: July 17, 2015
    Publication date: June 30, 2016
    Inventors: Shane L. MANGOLD, Robert H. GRUBBS