Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: A dispensing source container suitable for containing and dispensing fluid concentrate has an opening suitable for receiving a closure. The source container includes a fluid-tight vessel configured to hold fluid concentrate, and a pump connectable to the opening of the source container, the pump having a temporary reservoir, the pump being operable to withdraw a portion of the fluid concentrate from the source container and to store the portion of fluid concentrate in the temporary reservoir. The pump is also operable to dispense a metered amount of the fluid concentrate from the temporary reservoir to dispense the fluid concentrate from the source container into receiving containers.

Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: The invention relates to the use of protein design automation (P DA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract: A tool for pulling a valve stem and removing the valve core of a Schrader-type pneumatic valve includes an elongate flexible shaft having opposite end portions and a handle affixed to one end portion and a valve-core engaging member including a threaded rear portion and an unthreaded forked front portion for cooperating with a flat member of a Schrader-type valve core for rotating the core to remove it from the valve. The threaded rear portion is threadable into interior threads of the valve when the core has been removed for allowing a user of the tool to pull the valve through a wheel rim opening. The front forked portion of the valve-core engaging member includes a recess formed therein for accommodating a plunger of a Schrader-type valve therein to allow the forked portion to be positioned over the plunger in the valve to provide for engagement of the cooperating forked portion of the valve core.

Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Abstract: The clip applier of the current invention solves the problems of prior art tools by incorporating a pre-clamp mechanism, the function of which is to pre-clamp the vessel to be ligated to a dimension such that the center leg of the spring of the ligation clip need be lifted only slightly. In this manner the spring clip can be slid over the smaller pre-clamped dimension. This insures that the clip spring material will remain within its elastic limit while allowing the tool to maintain a low profile for use in endoscopic surgery, even on large diameter vessels.

Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract: The invention relates to the use of protein design automation (PDA™) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract: The invention relates to the use of RNA dependent RNA polymerase to generate libraries of proteins, and to methods of making and methods and compositions utilizing the libraries.

Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract: The invention relates to the use of protein design automaton (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.