Abstract: Apparatus for generating a supply of air at positive pressure for the amelioration or treatment of a respiratory disorder includes a first chamber, a second chamber, at least one inlet tube structured and configured to allow ambient air to enter the first chamber, at least one flow tube structured and configured to allow air to pass from the first chamber to the second chamber, and a blower structured and configured to produce a flow of air at positive pressure. The blower is positioned in the first chamber and structured and configured to receive air from the second chamber. The blower includes a housing structured and configured to sealingly separate air flow through an interior of the housing from the first chamber. The at least one inlet tube is axially spaced from the at least one flow tube.

Abstract: Uroflowmeters and methods for processing data generated therefrom are disclosed. In one aspect, the uroflowmeter is a handheld device. The uroflowmeter includes a handle, a flow chamber coupled to the handle, and a sensor associated with the flow chamber that detects a parameter of urine received in the flow chamber. The uroflowmeter may include both reusable and disposable components. As a uroflowmeter it can identify and record data corresponding to the rate of flow over the measured duration of a void of urine, but may also timestamp the voiding act and communicate the data to an external data collection center for additional analysis and incorporation into a comprehensive voiding report or voiding diary.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: A chemical indicator solution, an apparatus, and a method for determining concentration of a chemical analyte is provided. In particular, the apparatus provides a simplified and low cost way to determine that a fluid sample contains a minimum recommended concentration of a chemical. Rather than using complex and expensive components or error-prone manual methods to prepare the solution and measure chemical concentrations, the apparatus may allow for the automatic measuring and mixing of the chemical components of the resulting solution through the unique geometry and layout of the apparatus. The resulting solution may contain a chemical indicator which allows for the detection of the concentration of the chemical analyte within the resulting solution using techniques such as color analysis.

Abstract: In one aspect, a movable barrier operator system is provided that includes a motor configured to turn a drum to pay out a cable from the drum and permit a door connected to the cable to move from an open position toward a closed position. The system includes a memory configured to store an expected variable of the door, and a sensor configured to detect movement of the door. The system further includes a processor circuit operatively coupled to the motor, the memory, and the sensor. The processor circuit is configured to: use the sensor to estimate an actual variable of the door; determine whether the actual variable is acceptable based at least in part on the expected variable and the processor circuit causing the motor to turn the drum; and change operation of the movable barrier upon the actual variable of the movable barrier being unacceptable.

Abstract: A low loss silicon nitride film is formed by depositing a silicon nitride film on a substrate and annealing the silicon nitride film for at least ten hours at a temperature of at least 400° C. to cause the silicon nitride film to become a low loss silicon nitride film. The low loss silicon nitride film has an optical loss of less than 1 dB per cm at a wavelength of 488 nm.

Abstract: Systems, methods, and articles of manufacture for electronic gaming are disclosed. In a first aspect, a method of electronic gaming includes selecting a plurality of primary game symbols, displaying the plurality of primary game symbols, initiating, based upon the plurality of primary game symbols, a secondary game, displaying a trigger symbol in association with the secondary game, displaying a trigger symbol action associated with the trigger symbol, selecting a plurality of secondary game symbols in association with the secondary game (where one of the secondary game symbols comprising the trigger symbol), displaying the plurality of secondary game symbols, and performing the trigger symbol action based upon the trigger symbol.

Abstract: An article having a coating system configured to inhibit or prevent crystallization of TGO at the operating temperature of the article. An article includes a substrate defining a surface and a coating layer that includes a dopant configured to inhibit crystallization of amorphous silicon dioxide thermally grown oxide on the bond coat at an operating temperature of the article. The dopant includes a glass modifier. By inhibiting or preventing TGO crystallization, the described coating systems may increase a useable life of the component.

Abstract: A method of plugging channels of a honeycomb body and a honeycomb body including plugged channels. The method includes applying a shear force to a plugging mixture including a plurality of inorganic particles, clay, and a liquid vehicle to alter the viscosity of the plugging mixture from a first viscosity prior to the vibrating to a second viscosity which is less than the first viscosity. A honeycomb body is placed into contact with the plugging mixture such that a portion of the plugging mixture having the second viscosity flows into the plurality of channels. Application of the shear force is stopped or reduced to increase the viscosity of the portion of the plugging mixture in the plurality of channels to greater than the first viscosity.

Abstract: A method of manufacturing a vapour generating product includes positioning non-liquid vapour generating material in a space defined by one or more walls configured to prevent movement of the vapour generating material by more than 2 mm in a direction perpendicular to an axial direction of the vapour generating material, the one or more walls extending substantially in the axial direction of the vapour generating material. The method further includes aligning an axis of a rigid insertor with the axial direction of the vapour generating material and inserting the rigid insertor into the vapour generating material from a first end of the vapour generating material. An apparatus for manufacturing a vapour generating product is also disclosed.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Systems and methods for purposeful computing are disclosed that, among other things, include a user purpose class resource information computing environment. Such environment supports resource purpose classes, and further supports resource identification information sets that characterize their respective subject matter resources. The computing environment can be used to identify and evaluate one or more purpose class subject matter resource members.

Abstract: A filter for a vapour generating article includes a filter body having: a first end arranged as a mouthpiece; a second end opposite the first end arranged for attachment to a vapour generating article; the filter further including a cavity located within the filter body between the first and second ends, the cavity configured to allow a fluid including water to flow through the filter body from the second end to the first end; wherein the cavity includes a filter portion arranged to filter the fluid as it flows through the filter body; and wherein the filter portion is arranged to remove at least some of the water from the fluid as it flows through the filter body.

Abstract: In various embodiments, a washable mat system comprises a top cover removably attached to a bottom pad. The top cover comprises layers of material, including a top layer with a tufted loop pile, a water-resistant internal layer, and a bottom knit surface. The top cover is sufficiently malleable to be folded, rolled, compressed, and withstand multiple wash and dry cycles while maintaining material stability. The bottom pad also comprises layers of material, including a top layer to removably attach to the bottom knit surface of the top cover, an internal cushioning layer, and a non-slip bottom surface.

Abstract: An auto-retract scraper is described herein. The auto-retract scrape comprises a housing, a slider, a blade, a rotating hard stop, and a torsion spring. The rotating hard stop is rotated clockwise forcing the blade forward and out of the housing when the slider is engaged.

Abstract: Techniques relating to streaming video are disclosed. These techniques include identifying one or more streaming video sessions for one or more users based on a plurality of events relating to streaming video for the one or more users. The techniques further include storing data for the one or more streaming video sessions in an electronic database, based on the plurality of events, identifying a plurality of metadata relating to the events, and determining, based on a threshold value, a time to store at least a portion of the plurality of metadata in the electronic database, the time occurring after the storing the data for the one or more streaming video sessions. The techniques further include responding to a query for metrics relating to the one or more streaming video sessions by aggregating at least a portion of the stored data.

Abstract: In a handheld communication device capable of a plurality of wireless communication modes, a method of communication begins by receiving, at the handheld communication device, a notification of an available one of the wireless communication modes. Then, in a data communication window of the communication device, a user-indication of an active one of the available wireless communication modes is provided in accordance with the received communication mode indication. The data communication window is configured to facilitate data communication via the plurality of wireless communication modes, and facilitates the data communication via the active wireless communication mode.

Abstract: The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer.

Abstract: In one embodiment, a device obtains transaction data regarding a transaction attempted by a client of an online application within the online application. The transaction data is captured by instrumentation code inserted into the online application at runtime. The device identifies, based on the transaction data, traffic in a network associated with the transaction. The device associates, based on the transaction data, a measure of importance with the traffic. The device causes the traffic to be sent by a networking device in the network according to its associated measure of importance.

Abstract: Systems, methods, and apparatus to select an enhanced write pulse for a write operation in a memory device. In one approach, stronger reset pulses are triggered when there is an increased risk of memory cell threshold voltage degradation. Memory cells read by a relatively higher number of read operations are recorded by a controller of a memory device by updating a lookup table with addresses of the memory cells read. For a new write operation, the controller determines if a reset on set write operation is to be performed. The controller also searches the lookup table to determine if an address for the target bits or codeword of the write operation are in the lookup table. If both conditions are satisfied, then the magnitude of the write pulse is increased for programming the memory cells.