Abstract: Prophylaxis and treatment of patients susceptible to infection by coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is achieved using compositions including one or more inhibitors including sulfated glycans and/or highly negative charged compounds. The inhibitors bind to wild-type and variant spike glycoproteins (S-proteins or SGPs) of SARS-CoV-2, inhibiting fusion, entry, and infection of a host cell. The inhibitors can include pentosan polysulfate (PPS), mucopolysaccharide polysulfate (MPS), sulfated lactobionic acid, sulodexide, a defibrotide, 4-t-butylcalix[X] arene-p-sulfonic acid, or combinations thereof. The presence of additional sulfo groups in PPS and MPS contribute to the improved inhibitory activity of compositions with those sulfated glycans against COVID-19 compared with compositions containing heparin alone.

Abstract: An oven appliance may include a cabinet, a heating element, and a controller. The cabinet may define a cooking chamber. The heating element may be in thermal communication with the cooking chamber to heat a cooking utensil therein. The controller may be in operable communication with the heating element. The controller may be configured to initiate a directed cooking operation. The directed cooking operation may include capturing a first image of the cooking chamber, identifying the cooking utensil within the cooking chamber based on the captured first image, capturing a second image of the cooking chamber following capturing the first image, detecting changes in the cooking utensil based on the captured second image, and directing oven operation based on the detected changes.

Abstract: Systems and methods for fabricating indirect bonding trays are disclosed. Physical models of a patient's teeth can be created with non-functional placeholder brackets, impressions of which can be transferred to indirect bonding trays. This can create wells in which functional brackets can be placed into, reducing errors created from transferring functional brackets from the physical model onto the indirect bonding trays.

Abstract: A method and device (1) for transferring electronic information between a lesser trusted network (7) and a trusted network (8) is disclosed. The method comprises the steps of: receiving original electronic information from a lesser trusted network (7) in a first electrical zone (2); permitting the original electronic information to be transferred between the first electrical zone (2) and the second electrical zone (4) in one direction only; verifying the original electronic information for at least one predetermined characteristic within the second electrical zone (4) so as to provide a verifier output status and verified electronic information; forwarding the verified electronic information to a third electrical zone (3).

Abstract: A user interface system is provided. At least one engine is provided to receive message data from managed infrastructure that includes managed infrastructure physical hardware that supports the flow and processing of information, determine common characteristics of events and produce clusters of events relating to the failure of errors in the managed infrastructure. Membership in a cluster indicates a common factor of the events that is a failure or an actionable problem in the physical hardware managed infrastructure directed to supporting the flow and processing of information. One or more situations is created that is a collection of one or more events or alerts representative of the actionable problem in the managed infrastructure. A situation room is coupled to or includes a dashboard display computer system and a data system, the display computer system configured to generate a dashboard display configured to display situations from the clustered events.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: A method for producing an aromatic dianhydride includes reacting an aromatic diimide with a substituted or unsubstituted phthalic anhydride in an aqueous medium in the presence of an amine exchange catalyst to provide an aqueous reaction mixture including an N-substituted phthalimide, an aromatic tetraacid salt, and at least one of an aromatic triacid salt and an aromatic imide diacid salt. The method further includes removing the phthalimide from the aqueous reaction mixture by extracting the aqueous reaction mixture with an organic solvent using a single packed extraction column. The aromatic tetraacid salt is converted to the corresponding aromatic dianhydride. Aromatic dianhydrides prepared according to the method are also described.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

Abstract: The disclosure is directed to a method for recovering products from a fermentation broth. The disclosure relates to the use of extractive distillation to recover products which have close boiling points, such as ethanol and isopropanol, from a fermentation broth. In an embodiment, the recovery of product is completed in a manner that minimizes stress on the microbial biomass, such that it remains viable, at least in part, and may be recycled and reused in the fermentation process, which may result in increased efficiency in the fermentation process. The extractive distillation vessel reactor may be used downstream of a distillation vessel. To minimize stress on the microbial biomass the distillation vessel may be under vacuum. The extractive distillation vessel may be used alongside a separation vessel such that the separation vessel is capable of recycling extractive distillation agent.

Abstract: A method for making a semiconductor device may include forming a superlattice adjacent a semiconductor layer. The superlattice may include a plurality of stacked groups of layers, with each group of layers including a plurality of stacked base semiconductor monolayers defining a base semiconductor portion, and at least one non-semiconductor monolayer constrained within a crystal lattice of adjacent base semiconductor portions. The at least one non-semiconductor monolayer in a first group of layers of the superlattice may comprise oxygen and be devoid of carbon, and the at least one non-semiconductor monolayer in a second group of layers of the superlattice may comprise carbon.

Abstract: Provided herein are novel N- and C-terminal oxyntomodulin polypeptide binding molecules, and uses thereof, including a method for quantitating oxyntomodulin.

Abstract: A method for positioning sensor units in a detector module for a CT device includes arranging a connecting layer on a positioning substrate. Sensor units and readout units, forming sensor readout arrangements, are positioned relative to the positioning substrate. The sensor units are temporarily connected to the positioning substrate at a fixed position by the connecting layer. Electronics boards are positioned, and conductive connections are produced between the electronics boards and contacts of the readout units, such that sensor boards are obtained. The sensor units are then positioned by the positioning substrate relative to a module carrier and are attached to the module carrier, such that a detector module is obtained.

Abstract: A bond tester apparatus arranged for determining a strength of a bond and/or a material present on a base, said bond tester apparatus comprising a force measurement module for applying a shear force to said bond and/or said material, and a displacement module and a controller arranged for controlling the distance between the force measurement module and the displacement module such that the shear height of a shear tool can be set.

Abstract: A system and method for lift augmentation of an aircraft having a wing with a leading edge and a trailing edge extending along a wingspan, a plurality of thrust-producing devices connected to the bottom of said wing, at least one flap connected to an inboard portion of said wing proximate the trailing edge, and an aircraft roll control device connected to said wing, wherein the improvement comprises a plurality of slipstreams associated with a plurality of thrust producing devices and a flap adaptable to deflect from a chord of the inboard portion of the wing.

Abstract: A vapour generating article includes a main body having a first end and a second end opposite the first end, the body arranged to contain a vapour generating material; a filter having a first end arranged as a mouthpiece portion and a second end opposite the first end arranged for attachment to the first end of the main body; an air inlet portion located at the second end of the filter. The air inlet portion includes at least one aperture to allow ambient air to enter the filter. The filter includes an adjuster configured to move relative to air inlet portion to adjust the cross-sectional area of the aperture to alter an airflow through the aperture. The second end of the filter is releasably attachable to the first end of the main body.

Abstract: A vapour generating includes a main body having a first end and a second end opposite the first end, the body arranged to contain a solid vapour generating material; a filter having a mouthpiece end and an attachment end opposite the mouthpiece end, the attachment end arranged to be attached to the first end of the main body; and an airflow passageway within the filter configured to allow a vapour to flow into the filter through the attachment end from the first end of the body and out of the filter through the mouthpiece end. The filter includes an adjuster configured to adjust the length of the airflow passageway.

Abstract: An additive manufacturing machine and an energy beam system including an energy beam generator configured to output an energy beam through a first optical element along a first direction is provided. The energy beam system includes an optical translation system positioned to receive the energy beam through a steering optic. The steering optic is positioned within a translator apparatus. The translator apparatus is configured to translate the steering optic along a plane perpendicular to the first direction.

Abstract: An induction heating assembly for a vapour generating device is provided, the induction heating assembly including: an outer wall; an induction heating coil arranged inward of the outer wall and extending along the outer wall; a heating compartment defined inward of the outer wall and having a base portion at a first end of the induction coil and having an opening opposite of the base portion and arranged to receive, in use, via the opening, an elongated member to be heated by induction heating; and at least one movable member arranged such as to move in the longitudinal direction of the induction heating coil when a current is flowing through the induction heating coil.

Abstract: Systems and methods relating to dynamic spargers for generating fine bubbles within reactors such as biological and chemical reactors. A sparger system is positioned within a reactor and comprises a support plate, multiple annular shrouds engaged with the support plate, and spargers positioned within the annular shrouds defining a gap between an interior surface of the annular shroud and an exterior surface of the corresponding sparger. Liquid flows through the defined gap between an interior surface of the annular shroud and an exterior surface of the sparger. Acceleration of the liquid through the gap shears bubbles at the exterior surface of the sparger creating bubbles or fine bubbles.

Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.