Patents by Inventor Robert Kaiser

Robert Kaiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220275019
    Abstract: Compounds useful for forming nucleic acids having the structure of Formula I: Each of R1 or R2 is independently selected from hydrogen, a protecting group, or a phosphoramidite group. R3 is selected from H, F, O—C1-6 alkyl, O-MOE and a removable hydroxyl-protecting group. Q is a heterocyclic base. R4 is a cyclic hydrocarbon. Also disclosed are processes for forming the nucleic acids from the compounds and the nucleic acid products produced.
    Type: Application
    Filed: February 26, 2022
    Publication date: September 1, 2022
    Inventors: Benjamin D. Lunstad, Douglas J. Dellinger, Robert Kaiser
  • Patent number: 11407147
    Abstract: In various embodiments, a vapor condensation thermoplastic part finishing technique is provided that smooths and ensures color saturation of thermoplastic parts. The technique uses nonhazardous vapor condensation to rapidly heat a thermoplastic part to a temperature higher than its melting temperature. The part then may be cooled to a temperature lower than its melting temperature (and preferable lower than its glass-transition temperature. In some cases, evaporation may be employed to rapidly cool the part. Condensation and, where applicable evaporation, may be promoted by pressure changes to the nonhazardous vapor (e.g., increasing pressure to above atmospheric pressure and then decreasing pressure back to atmospheric pressure), exposure of the part to a separately-heated cloud of nonhazardous vapor (e.g., moving the part into and then out of the separately-heated cloud or injecting and then stopping injection of separately-heated vapor), or by other techniques.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: August 9, 2022
    Assignee: Entropie Systems, Inc.
    Inventor: Robert Kaiser
  • Publication number: 20220195425
    Abstract: Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies, Inc.
    Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
  • Publication number: 20220195427
    Abstract: Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies, Inc.
    Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
  • Publication number: 20220195426
    Abstract: Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Applicants: The Board of Trustees of the Leland Stanford Junior Univerisity, Agilent Technologies, Inc.
    Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
  • Patent number: 11306309
    Abstract: Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: April 19, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies
    Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
  • Publication number: 20210079389
    Abstract: The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
    Type: Application
    Filed: November 24, 2020
    Publication date: March 18, 2021
    Inventors: Daniel E. RYAN, Douglas J. DELLINGER, Jeffrey R. SAMPSON, Robert KAISER, Joel MYERSON
  • Patent number: 10900034
    Abstract: The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: January 26, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Daniel E. Ryan, Douglas J. Dellinger, Jeffrey R. Sampson, Robert Kaiser, Joel Myerson
  • Patent number: 10801623
    Abstract: A device and method for extending the lifespan of a shaft seal for an open-drive compressor is provided. The device and method can also reduce and/or prevent deterioration of the shaft seal regardless of the operation condition of the open-drive compressor. The device and method can further reduce and/or prevent leakage of a lubricant and/or refrigerant that can cause deterioration of components within a transport refrigeration unit (TRU).
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: October 13, 2020
    Assignee: Thermo King Corporation
    Inventors: Joseph Robert Kaiser, David John Dykes, Ralph David Price, Ryan Michael Fritts
  • Patent number: 10688323
    Abstract: A safety device with fall arrest and descending modes includes a housing, a drum, a lifeline, first and second brake assemblies, and a control. The drum is rotatably operatively connected to the housing. The lifeline has an intermediate portion interconnecting a first end and a second end. The first end is operatively connected to the drum. The first and second assemblies are operatively connected to the drum. The control is operatively connected to the first and second brake assemblies and has a first position and a second position. The first position selectively engages the first brake assembly in a descending mode and the second position selectively engages the second brake assembly in a fall arrest mode.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: June 23, 2020
    Assignee: D B INDUSTRIES, LLC
    Inventors: J. Thomas Wolner, Scott C. Casebolt, Gabriel Grant Gamache, Matthew J. Blackford, Vincent G. Meillet, Joseph Robert Kaiser
  • Publication number: 20190344813
    Abstract: A track measuring vehicle for recording a track geometry of a track includes a vehicle frame which has rail undercarriages and is mobile on two rails of a track. The vehicle also includes a first measuring base on which are arranged an inertial measuring unit and, for a position determination relative to each rail, at least one contact-less position measuring device. A lowerable second measuring base has measuring running wheels designed to be set upon the rails and is connected to the first measuring base via compensation measuring devices.
    Type: Application
    Filed: November 27, 2017
    Publication date: November 14, 2019
    Inventors: CHRISTOPH KAISER, ROBERT KAISER
  • Patent number: 10337001
    Abstract: The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: July 2, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Daniel E. Ryan, Douglas J. Dellinger, Jeffrey R. Sampson, Robert Kaiser, Joel Myerson
  • Patent number: 10159244
    Abstract: The present invention relates to a novel method for the preparation of a pooled or mixed population of cryopreserved cells (e.g. hepatocytes). In particular, the invention entails the rapid thaw of cells (e.g. hepatocytes), donated from a single individual, which are mixed to create a heterogeneous population and then cryopreserved. The invention also concerns preparations of multi-cryopreserved cells to increase viability prior to immediate use. The process entails reducing exposure to chemical and physical stresses to increase the resultant number of viable cells.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: December 25, 2018
    Assignee: LONZA WALKERSVILLE, INC.
    Inventors: Matthew Sherman, Robert Kaiser
  • Publication number: 20180163871
    Abstract: A device and method for extending the lifespan of a shaft seal for an open-drive compressor is provided. The device and method can also reduce and/or prevent deterioration of the shaft seal regardless of the operation condition of the open-drive compressor. The device and method can further reduce and/or prevent leakage of a lubricant and/or refrigerant that can cause deterioration of components within a transport refrigeration unit (TRU).
    Type: Application
    Filed: February 8, 2018
    Publication date: June 14, 2018
    Inventors: Joseph Robert KAISER, David John DYKES, Ralph David PRICE, Ryan Michael FRITTS
  • Publication number: 20180119140
    Abstract: Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.
    Type: Application
    Filed: October 3, 2017
    Publication date: May 3, 2018
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies, Inc.
    Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
  • Publication number: 20180051281
    Abstract: The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
    Type: Application
    Filed: May 26, 2017
    Publication date: February 22, 2018
    Inventors: Daniel E. Ryan, Douglas J. Dellinger, Jeffrey R. Sampson, Robert Kaiser, Joel Myerson
  • Patent number: 9897211
    Abstract: A device and method for extending the lifespan of a shaft seal for an open-drive compressor is provided. The device and method can also reduce and/or prevent deterioration of the shaft seal regardless of the operation condition of the open-drive compressor. The device and method can further reduce and/or prevent leakage of a lubricant and/or refrigerant that can cause deterioration of components within a transport refrigeration unit (TRU).
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: February 20, 2018
    Assignee: THERMO KING CORPORATION
    Inventors: Joseph Robert Kaiser, David John Dykes, Ralph David Price, Ryan Michael Fritts
  • Patent number: 9498400
    Abstract: A method and a continuous passive motion device for providing a dynamically loaded force and a static progressive force to a joint of a patient.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: November 22, 2016
    Assignee: Lantz Medical Inc.
    Inventor: Robert Kaiser
  • Publication number: 20160289675
    Abstract: The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
    Type: Application
    Filed: December 3, 2015
    Publication date: October 6, 2016
    Inventors: Daniel E. Ryan, Douglas J. Dellinger, Jeffrey R. Sampson, Robert Kaiser, Joel Myerson
  • Publication number: 20160249602
    Abstract: The present invention relates to a novel method for the preparation of a pooled or mixed population of cryopreserved cells (e.g. hepatocytes). In particular, the invention entails the rapid thaw of cells (e.g. hepatocytes), donated from a single individual, which are mixed to create a heterogeneous population and then cryopreserved. The invention also concerns preparations of multi-cryopreserved cells to increase viability prior to immediate use. The process entails reducing exposure to chemical and physical stresses to increase the resultant number of viable cells.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 1, 2016
    Applicant: Triangle Research Labs, LLC
    Inventors: Matthew Sherman, Robert Kaiser