Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.

Abstract: System and methods for creating shaped, non-circular boreholes in rocks especially for use with geothermal heat pump applications and for increasing wellbore support in applications such as horizontal oil and gas drilling are described. The systems and methods when applied to geothermal heat pumps create an elliptical shaped hole that is optimized for placing heat transfer tubes with a minimum of grout used. The significantly reduced cross-sectional area of the elliptical borehole also increases the overall drilling rate in rock and especially in hard rocks. In horizontal hard-rock drilling, creation of a horizontal non-circular borehole or modification of a circular borehole to a non-circular geometry is used to stabilize the borehole prior to casing insertion, and may also allow the use of lower mud pressures improving drilling rates. The system uses a non-contacting drilling system which in one embodiment uses a supersonic flame jet drilling system with a movable nozzle that swings between pivot points.

Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.

Abstract: A device for use in a restaurant as a source of light for the table area comprising a housing, a power circuit and at least one light source. The housing has an integral base that is configured to support the housing on a table. The power circuit has a power source positioned therein the housing and a pressure switch. The at least one light source is positioned therein the housing proximate an aperture in the base and is electrically coupled to the power circuit. The pressure switch is configured to selectively open and close the power circuit such that the at least one light source can be selectively energized by either placing the housing on the table, such that the at least one light source is in a de-energized position, or lifting the housing upwardly away from the table, which energizes the at least one light source.

Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof

Abstract: The present invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the compound N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-5-(trifluoromethyl)-2-pyrimidinecarboxamide.

Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R1, R2, R6, R7, R8, R9 and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises pharmaceutical formulations comprising these compounds and combinations of these compounds and one or more other therapeutic agents.

Abstract: A suspension of particles is rapidly self-assembled with a minimal number of defects into a three-dimensional array of particles onto a substrate under simultaneous sedimentating and annealing forces. This array of particles may be ordered as an opal structure. Optionally, the synthesized structure may incorporate an electrolyte into the suspension and be used as a sacrificial form for micromoulding an inverse structure. The inverse structure may exhibit a photonic band gap. Optionally, necking and material composition may be adjusted after micromoulding. These structures are useful to a wide variety of applications. The photonic band gap structure may be heated to function as a light source. The light source may be fitted into standard sockets.

Abstract: According to one embodiment of the invention, a method for self-testing a portion of a line card having a digital signal processor for manipulating data received by the line card, and a transmit channel and a receive channel coupled to a combined transmit and receive channel includes transmitting a test signal through at least a portion of the transmit channel toward the combined channel and detecting, by the digital signal processor any resulting signal in the receive channel to determine whether any components in the transmit channel, receive channel or combined channel are malfunctioning.

Abstract: A compressor wash nozzle integrated in an inlet case strut of a turbine engine is described. A fluid passage and a nozzle are defined in the inlet case strut for delivering a wash/rinse fluid into the inlet gas path of the engine. A fluid connector communicates with the fluid passage and is positioned exteriorly of the inlet gas strut and adapted for receiving pressurized wash/rinse fluid for injection through the nozzle into gases flowing in the inlet gas path and in the direction of the compressor for washing and/or rinsing the blades of the compressor.

Abstract: Monodisperse polymer microparticles comprising polystyrene or polyacrylate, wherein said particles have a coating formed of at least one transition metal oxide or porous polymer microparticles comprising polystyrene or polyacrylate, wherein said particles have a coating formed of at least one transition metal oxide.

Abstract: A system and method for lower cost, solar thermal generation includes a thermal input block, and an energy storage block.

Abstract: Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).

Abstract: A pack comprising, in one aspect, a first enclosure and a pair of sleeves. The open end of each sleeve being connected to one respective slit of a pair of slits defined on the exterior surface of the first enclosure such that the pair of sleeves is disposed therein a first interior cavity of the first enclosure to form pockets adapted to receive a user's hands. The pack may also comprise a second enclosure and a shoulder strap connected to portions of the exterior surface of the respective first and second enclosures.

Abstract: The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R6, R7, R9, R10, R11, X, n, p, Ar and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.

Abstract: A method and apparatus is provided for hosting within a search engine, large-scale heterogeneous repositories of searchable and navigable content. Customers of the hosting platform are customers wanting to outsource the management of their searchable content. Content domain experts from each customer independently define a taxonomy of categories and attributes for their structured content that form a hierarchical set of nodes (a directed graph) that are mapped to a common physical search engine infrastructure. The mapping algorithm that maps unique attributes across potentially very different subject domains onto the same physical infrastructure is introduced. Once the physical structure is created, the search engine can use it for searching or navigating just within one customer's domain or users can search across multiple customer domains.

Abstract: System and methods for creating shaped, non-circular boreholes in rocks especially for use with geothermal heat pump applications and for increasing wellbore support in applications such as horizontal oil and gas drilling are described. The systems and methods when applied to geothermal heat pumps create an elliptical shaped hole that is optimized for placing heat transfer tubes with a minimum of grout used. The significantly reduced cross-sectional area of the elliptical borehole also increases the overall drilling rate in rock and especially in hard rocks. In horizontal hard-rock drilling, creation of a horizontal non-circular borehole or modification of a circular borehole to a non-circular geometry is used to stabilize the borehole prior to casing insertion, and may also allow the use of lower mud pressures improving drilling rates. The system uses a non-contacting drilling system which in one embodiment uses a supersonic flame jet drilling system with a movable nozzle that swings between pivot points.

Abstract: This invention describes a method of reducing the effect of interfering compounds in a bodily fluid when measuring an analyte using an electrochemical sensor. In particular, the present method is applicable to electrochemical sensors where the sensor includes a substrate, first and second working electrodes, and a reference electrode and either the first and second or only the second working electrode include regions which are bare of reagent. In this invention, an algorithm is described with mathematically corrects for the interference effect using the test strip embodiments of the present invention.

Abstract: Compounds of formula (I) and salts and solvates are provided. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.