Abstract: A zipper member type of closure mechanism is mounted to a bag by adhesive materials having contrasting characteristics selected for providing advantages. The closure mechanism is mounted proximate an opening of the bag, so that the closure mechanism is positioned for use in opening and closing the bag.

Abstract: A rotor blade having a detachable fairing is disclosed. The rotor blade includes leading and trailing edge fairings secured to the blade spar and one or more control lines extending between of the fairings and the blade spar. A detachable fairing extends from one or both of the leading and trailing edge fairings toward one of the distal and proximal ends of the blade spar. The detachable fairing and blade spar form an airfoil contour. The detachable fairing may secure to a tip jet attachment fitting at a distal end of the blade spar. A mounting structure including upper and lower plates may secure near a proximal end of the blade spar and the detachable fairing may secure to both the upper and lower plates to form all or part of an airfoil contour. The mounting structure may include a spherical seat engaging a spherical surface of a hub shroud.

Abstract: The present invention relates to molds used to manufacture concrete block having customizable color and textures. The present invention also relates to the methods of making the molds and to methods of manufacturing the substitute blocks.

Abstract: An aircraft is disclosed having an engine and a propeller mounted to a fuselage. An empennage mounts to the aircraft and includes first and second horizontal stabilizers separated by a distance greater than the diameter of a stream tube of the propeller at the horizontal stabilizers. A rudder extends between the horizontal stabilizers and is positioned within the stream tube of the propeller. The rudder may mount to a first vertical stabilizer extending between the horizontal stabilizers. The horizontal stabilizers may be secured to second and third vertical stabilizers to form a duct having the rudder positioned within the duct. Additional rudders may mount to the second and third vertical stabilizers.

Abstract: The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity.

Abstract: A wind turbine has a rotor with a hub that houses a remote sensing device such as a Lidar for each blade. Each Lidar has one or more look directions that extend generally radially along the respective blade in front of the blade. The Lidar has multiple range gates and wind parameters sensed at each range may be used to control surfaces on the blade such as a trailing edge flap.

Abstract: Versions of the invention are directed to methods and apparatus for a new type of association-based linkage study technique using bi-allelic markers. The markers used in this technique are chosen so that the least common allele frequencies of the markers vary systematically over a range or subrange of least common allele frequency and the chromosomal location of the markers vary systematically over one or more chromosomal regions or chromosomes to achieve a systematic distribution of the markers over a two-dimensional region that has the orthogonal dimensions of chromosomal location and least common allele frequency. By using the two characteristics or two dimensions of marker chromosomal location and marker allele population frequency in this way, the power and systematic nature of genetic linkage studies using association-based linkage tests is greatly increased. These two-dimensional linkage study techniques increase the power of association studies to localize trait-causing polymorphisms of modest effect.

Abstract: Versions of the invention are directed to methods and apparatus for a new type of association-based linkage study technique using bi-allelic markers. The markers used in this technique are chosen so that the least common allele frequencies of the markers vary systematically over a range or subrange of least common allele frequency and the chromosomal location of the markers vary systematically over one or more chromosomal regions or chromosomes to achieve a systematic distribution of the markers over a two-dimensional region that has the orthogonal dimensions of chromosomal location and least common allele frequency. By using the two characteristics or two dimensions of marker chromosomal location and marker allele population frequency in this way, the power and systematic nature of genetic linkage studies using association-based linkage tests is greatly increased. These two-dimensional linkage study techniques increase the power of association studies to localize trait-causing polymorphisms of modest effect.

Abstract: An automatically provisioned virtual private data center provided on a cloud network of multiple virtual private data centers that reside in one or more physical data centers and may migrate between multiple physical data centers. The VPDC is a encapsulated virtual structure provisioned according to customer selected options within a virtual data center having one or more foundation nodes. Different service profiles are provided in a provisioning interface to the customer, each defining several configuration specifics that are used to automatically provision a VPDC for the customer.

Abstract: An electrochemical cell for testing the electrochemical behavior of a plurality of materials comprises: a first electrode; a counter-electrode bearing an electrochromic material having a visual or measurable property which changes in a manner proportional to the total charge passed through it; and an electrolyte between and in electrical contact with the first electrode and the counter-electrode; wherein one of the first electrode and the electrolyte comprises a plurality of regions, each region comprising a sample of material to be tested, the regions being, in the case of the first electrode, electrically connected to a common terminal. Such a cell can be used for a “combinatorial chemistry” approach to testing the properties of possible cell components.

Abstract: Monoclonal anti-myostatin antibodies that preferentially bind myostatin over GDF-11, have strong binding affinity to myostatin and are resistant to chemical degradation. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment or prevention of various disorders in mammalian and avian species.

Abstract: An electronic device package comprising: a block of insulating material; an electronic device housed within the insulating material and having a set of contact pads thereon; and a set of electrically conductive contact members at least partially housed within the insulating material, each contact member extending between a respective external contact point at which it is exposed at the surface of the block and an internal contact point from which it is electrically coupled to a respective contact pad on the electronic device, each internal contact point being outside the footprint of the electronic device, the set of contact members including: at least one contact member of a first type whose external contact point is located at least partially within the footprint of the electronic device; and at least one contact member of a second type that is wholly outside the footprint of the device.

Abstract: A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

Abstract: A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11?HSD1, processes for making them and pharmaceutical compositions comprising them are also described.

Abstract: A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

Abstract: An electrochemical cell comprising a cathode, an anode and an electrolyte is provided, wherein: the cathode comprises mesoporous nickel having a periodic arrangement of substantially uniformly sized pores of cross-section of the order of 10?8 to 10?9 m; and the anode comprises a mesoporous material having a periodic arrangement of substantially uniformly sized pores of cross-section of the order of 10?8 to 10?9 m and selected from: carbon, cadmium, iron, a palladium/nickel alloy, an iron/titanium alloy, palladium or a mixed metal hydride.

Abstract: The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity.

Abstract: Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11?HSD1, processes for making them and pharmaceutical compositions comprising them are described.

Abstract: New crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid; their use in the inhibition of 11?HSD1, processes for making them and pharmaceutical compositions comprising them are also described.

Abstract: A compound of formula (I): and pharmaceutically-acceptable salts thereof, wherein the variable groups are defined within; their use in the inhibition of 11?HSD1, processes for making them and pharmaceutical compositions comprising them are also described herein.