Abstract: The present application is directed towards compounds, pharmaceutically acceptable salts or prodrugs thereof, which are inhibitors of Histone Deacetylase (HDAC) binding or function. The compounds especially may have some selectivity for inhibiting Class IIa versus Class I HDACs. The present application also relates to methods of using the compounds and to uses of the compounds, especially in relation to the prevention of a disease, disorder or condition associated with Class IIa HDAC activity. In one form, the compounds are (ortho-phenyl) phenyl hydroxamates. In another form, the compounds are as provided in Formula (I), wherein R1 is a phenyl or cycloalkenyl which may be optionally substituted.

Abstract: A system includes an imaging instrument and a cleaning device. The imaging instrument includes a shaft having a proximal end and a distal end and a viewing portion proximate the distal end of the shaft. The cleaning device includes a tubular member having a distal end and a proximal end, one or more fluid inlets, and one or more fluid outlets. The fluid inlets are fluidically coupled with one or more fluid passages extending longitudinally through the tubular member. The fluid outlets are proximate the tubular member distal end and are also fluidically coupled with the one or more fluid passages. The tubular member is configured to receive the shaft of the imaging instrument. When the shaft of the imaging instrument is received in the tubular member, the tubular member does not protrude radially inwardly beyond an outer perimeter of the viewing portion of the imaging instrument.

Abstract: A surgical instrument comprises first and second jaws movable relative to each other between open and closed positions, a cutting electrode with a cutting surface for tissue dissection and at least one sealing electrode for sealing or coagulating tissue. The cutting electrode includes one or more insulation layers for securing the cutting electrode to one of the jaws and for protecting the jaws from the heat and energy generated at the cutting surface during operation. An actuator mechanism is coupled to the first and second jaws for moving the jaws between the open and closed positions. At least one portion of the actuator mechanism comprises a conductive pathway for electrically coupling the cutting and/or sealing electrode(s) to a source of energy. Thus, the mechanical components of the actuator mechanism include electrically conductive pathways to reduce the number of conductors extending through the device, thereby providing a more compact and maneuverable instrument.

Abstract: The present invention provides a smart air filter blockage detection and alert communication system for use with filters in air circulation systems such as HVAC, vehicles, server systems, and dryers. The system attached to the frame of a filter comprises a light source, a light sensor, two actuators and a control unit. The control unit based on a stored program or an external command activates the actuators to place the source and the sensor devices attached to the two arms of the actuators on the two sides of the filter membrane. The sensor measures the light intensity transmitted through the filter. The control unit upon receiving the intensity data determines the filter blockage level and communicates alert to the user when the blockage exceeds a predetermined value. The system uses a 4G or a 5G IoT network capability for data collection and communication with servers and user devices.

Abstract: A device for cleaning an instrument includes a manifold comprising one or more fluid inlets, and a tubular member rotatable relative to and extending distally from the manifold. The tubular member includes a proximal end, a distal end, and a fluid outlet at the distal end. The fluid outlet is configured to direct a flow of fluid generally across the distal end of the tubular member. The tubular member also includes one or more fluid passages fluidically coupled to the fluid outlet, and the one or more fluid passages extend from the fluid outlet to the manifold. The manifold and tubular member are configured to receive a shaft of an imaging instrument in a position such that the shaft of the imaging instrument extends through the manifold to the distal end of the tubular member. Systems and methods relate to instruments and cleaning devices.

Abstract: The present application is directed towards compounds, pharmaceutically acceptable salts or prodrugs thereof, which are inhibitors of Histone Deacetylase (HDAC) binding or function. The compounds especially may have some selectivity for inhibiting Class IIa versus Class I HDACs. The present application also relates to methods of using the compounds and to uses of the compounds, especially in relation to the prevention of a disease, disorder or condition associated with Class IIa HDAC activity. In one form, the compounds are (ortho-phenyl) phenyl hydroxamates. In another form, the compounds are as provided in Formula (I), wherein R1 is a phenyl or cycloalkenyl which may be optionally substituted.

Abstract: A cover for a car includes a cloth or clothlike cover base, a tinted aluminum coating disposed on an outer surface of the cloth or clothlike cover base; and one or more security flaps connected to an inner surface of the cloth or clothlike cover base at a position that enables the one or more security flaps to be inserted into one or more of the car's doors.

Abstract: A device for cleaning an instrument includes a manifold comprising one or more fluid inlets, and a tubular member rotatable relative to and extending distally from the manifold. The tubular member includes a proximal end, a distal end, and a fluid outlet at the distal end. The fluid outlet is configured to direct a flow of fluid generally across the distal end of the tubular member. The tubular member also includes one or more fluid passages fluidically coupled to the fluid outlet, and the one or more fluid passages extend from the fluid outlet to the manifold. The manifold and tubular member are configured to receive a shaft of an imaging instrument in a position such that the shaft of the imaging instrument extends through the manifold to the distal end of the tubular member. Systems and methods relate to instruments and cleaning devices.

Abstract: A surgical instrument comprises first and second jaws movable relative to each other between open and closed positions, a cutting electrode with a cutting surface for tissue dissection and at least one sealing electrode for sealing or coagulating tissue. The cutting electrode includes one or more insulation layers for securing the cutting electrode to one of the jaws and for protecting the jaws from the heat and energy generated at the cutting surface during operation. An actuator mechanism is coupled to the first and second jaws for moving the jaws between the open and closed positions. At least one portion of the actuator mechanism comprises a conductive pathway for electrically coupling the cutting and/or sealing electrode(s) to a source of energy. Thus, the mechanical components of the actuator mechanism include electrically conductive pathways to reduce the number of conductors extending through the device, thereby providing a more compact and maneuverable instrument.

Abstract: Various embodiments of an aquarium and its method of use are disclosed. In some embodiments, the aquarium includes a first container for holding water and fish, plants, and/or other aquatic organism, a second container for collecting dirty water, and a passageway arranged to flush water from the first container to the second container. The passageway is in fluid communication with an outlet of the first container. The second container is arranged to receive the outlet such that fluid flows from the passageway, through the outlet, and into the second container. The outlet may be selectively opened by a user via a valve. Opening the valve causes gravity to flush water and debris from the first container, through the passageway, through the valve and into the second container, where the dirty water can be stored or discarded by disconnecting the second container from the aquarium ad dumping the dirty water.

Abstract: Filtering device (20) to draw water from an aquarium and the like and make water circulate inside, including a container (30) comprising a first housing portion (32) having a first inlet (174) and a second inlet (176) for the entry of water taken from the aquarium into the first housing portion (32) which is able to contain at least one filter for filtering water, further including a flow control device (50) having an entry (60) for taking water from the aquarium and it has two operating positions, a first operating position or filtering position wherein the entry (60) is in communication with the first inlet (174), so that water taken from the aquarium is put into the first housing portion (32), passes through the first inlet (174), is filtered and then is put back into the aquarium, and a second operating position or cleaning position or backwash position, wherein the entry (60) is in communication with the second inlet (176), water taken from the aquarium enters into the first housing portion (32) through

Abstract: Various embodiments of an aquarium and its method of use are disclosed. In some embodiments, the aquarium includes a first container for holding water and fish, plants, and/or other aquatic organism, a second container for collecting dirty water, and a passageway arranged to flush water from the first container to the second container. The passageway is in fluid communication with an outlet of the first container. The second container is arranged to receive the outlet such that fluid flows from the passageway, through the outlet, and into the second container. The outlet may be selectively opened by a user via a valve. Opening the valve causes gravity to flush water and debris from the first container, through the passageway, through the valve and into the second container, where the dirty water can be stored or discarded by disconnecting the second container from the aquarium ad dumping the dirty water.

Abstract: Filtering device (20) to draw water from an aquarium and the like and make water circulate inside, including a container (30) comprising a first housing portion (32) having a first inlet (174) and a second inlet (176) for the entry of water taken from the aquarium into the first housing portion (32) which is able to contain at least one filter for filtering water, further including a flow control device (50) having an entry (60) for taking water from the aquarium and it has two operating positions, a first operating position or filtering position wherein the entry (60) is in communication with the first inlet (174), so that water taken from the aquarium is put into the first housing portion (32), passes through the first inlet (174), is filtered and then is put back into the aquarium, and a second operating position or cleaning position or backwash position, wherein the entry (60) is in communication with the second inlet (176), water taken from the aquarium enters into the first housing portion (32) through

Abstract: The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.

Abstract: The present application provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of—or susceptible to—a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity.

Abstract: A display pixel includes a first fluid channel, a second fluid channel in flow communication with the first fluid channel, and a third fluid channel in flow communication with the second fluid channel. The first fluid channel includes a first fluid having a first color characteristic. The second fluid channel includes a second fluid having a second color characteristic, and the third fluid channel includes a third fluid having a third color characteristic. A display apparatus includes a plurality of the display pixels.

Abstract: A device cover includes a protective layer and a display layer. The display layer includes a plurality of display pixels. Each display pixel includes a first fluid having a first color characteristic and a second fluid having a second color characteristic.

Abstract: Various embodiments of an aquarium and its method of use are disclosed. In some embodiments the aquarium includes a first container including a waste collection area, an outlet, and a conduit fluidly connecting the waste collection area and the outlet. Depending upon the particular embodiment, the aquarium may also include features such as a second container adapted and configured to mate with the first container and receive the outlet such that fluid flows from the waste collection area through the outlet and into the second container when fluid is added above a preselected fluid level. In other related embodiments, the conduit may be formed by first and second portions of the conduit formed in the first container and a separate component.

Abstract: The present application provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of—or susceptible to—a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity.

Abstract: The present invention relates to the field of safety management of one or more vehicles, and more particularly, to a system and method for analyzing information relating to a vehicle's performance characteristics such as speed against environmental attributes such as speed limits to assess a vehicle and operator's tendency to operate according to preset or other criteria.