Abstract: An agent delivery device includes an inner tubular body having a proximal end, a sharpened distal end, a delivery lumen extending therebetween, and one or more outlet ports on the distal end communicating with the delivery lumen. The device also includes one or more seals sealing the one or more outlet ports, the one or more seals capable of being melted to allow a fluid to be delivered from the delivery lumen through the one or more outlet ports. The agent delivery device may further include a monopolar or bipolar electrode and/or a radio-opaque marker carried at the distal end of the device. The inner tubular body can be made from a conductive material to thereby allow the inner tubular body to function as an electrode.

Abstract: A system for treating tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and the distal ends, and an array of delivery tubes at least partially disposed within the lumen, each of the delivery tube having a lumen, wherein each of the delivery tubes is slidable relative to the cannula, and has a first configuration when inside the lumen, and a second configuration when outside the lumen. A system for treating tissue includes a treatment device having a distal end, and an indexing device for controlling a longitudinal position of the distal end of the treatment device relative to a target tissue region, the indexing device having a tubular portion for receiving the treatment device.

Abstract: A urethral prosthesis with prostatic and bulbar segments connected by two types of ties allows the prosthesis to assume at least two configurations different with inter-segmental distances adapted to situations where the patient either has or does not have normal control of the external sphincter. This is particularly useful for a patient undergoing an anesthetic procedure that affects the external sphincter muscles. When the muscles are anesthetized, the prosthesis may provide constant urine voiding, and when the anesthetic effects wear off, the prosthesis may assume a different configuration to allow the sphincter to reassert control over urinary voiding.

Abstract: Apparatus for positioning of a medical device in body tissue includes an angle indexer which mates in at least two positions with an index-key attached to the medical device. The indexer may be hand held or otherwise secured to a separate device, such as an introducer cannula, with the medical device being rotatable relative to the indexer.

Abstract: An apparatus for delivering electrical energy includes a cannula and one or more needles extendable from and retractable into a lumen of the cannula. A distal portion of each needle is extendable from the lumen and terminates in a tissue-piercing distal tip. Each distal portion is formed from an electrically conductive and porous material, thereby providing a porous electrode through which electrolytic fluid may flow for delivering electrical energy to tissue surrounding the distal portion. The cannula is introduced into a tissue structure of a patient, the one or more needles are advanced from the cannula, saline is introduced from the porous material to surrounding tissue, and electrical energy from an RF generator is delivered to ablate tissue within the tissue structure.

Abstract: According to an aspect of the invention, an indwelling catheter is provided which comprises a catheter shaft. The catheter either comprises a light source or is adapted to receive light from a light source, and is configured such that light is transmitted from the light source into the catheter shaft. Moreover, the catheter shaft is formed of a polymeric material that transmits a quantity of light from the light source that is effective to inactivate microorganisms on a surface of the catheter shaft upon activation of the light source. For example, the light may inactivate the microorganisms directly or in conjunction with a photosensitizer. According to another aspect of the invention, a sterilization method is provided, which comprises activating the light source while the catheter is inserted in a subject.

Abstract: Methods for the treatment of asthma are provided, which comprise: (a) providing an implantable or insertable medical device that comprises an asthma treatment agent; and (b) inserting or implanting the medical device within the lungs (e.g., the trachea or the bronchial tree) of a patient, whereupon the therapeutic agent is delivered to the patient in an amount effective to reduce or eliminate the symptoms of asthma. Also disclosed herein are medical devices and kits for carrying out such methods.

Abstract: A system for resecting tissue includes a loop structure configured for cutting tissue, at least a portion of the loop structure formed by an elongate structure having a first end and a second end, wherein a length of the loop structure is adjustable by positioning the first end relative to the second end, wherein a first portion of the loop structure comprises a first electrode, and a second portion of the loop structure comprises a second electrode. A system for resecting tissue includes a loop structure configured for cutting tissue, the loop structure formed by an elongate structure having a first end and a second end, wherein a length of the loop structure is adjustable by positioning the first end relative to the second end, and a support structure coupled to a portion of the elongate structure and having a surface for contacting tissue.

Abstract: A tissue ablation probe comprises an electrically conductive probe shaft, at least one electrode, and an electrically insulative sheath disposed on the probe shaft. The insulative sheath has thickened regions forming alternating ribs and depressions that longitudinally extend along the probe shaft. The ribs allow the ablation probe to be delivered through a tightly toleranced delivery device. While the ribs may shear off during the delivery process, the underlying probe shaft will remain covered by the remaining portion of the insulative sheath. The tissue ablation probe may be used in a tissue ablation assembly that additionally comprises a delivery cannula having a lumen in which the tissue ablation probe may be removably disposed. In this case, the sheath has an outer periphery having a size substantially the same as the diameter of the lumen, so that the inner surface of the delivery cannula cooperates with the depressions to create lumens that longitudinally extend within the cannula.

Abstract: A system for vessel embolization, comprising a mapping element measuring dimensions of a target vessel and a computing element computing a volume of a selected portion of the target vessel based on the dimensions of the blood vessel in combination with an embolization material delivery element including a distal end which, when in an operative position, opens into the target vessel to deposit the embolization material into the selected portion of the target vessel.

Abstract: A method includes identifying an area of interest within a gastrointestinal lumen based on a virtual imaging modality. Energy is applied using an external energy source directed at the area of interest sufficient to disrupt at least a portion of an undesired tissue. In another embodiment, the method includes introducing a contrasting agent into a gastrointestinal lumen. The gastrointestinal lumen is imaged with an imaging device. An area of interest within the gastrointestinal lumen is identified, where the area of interest is indicated by the contrasting agent. Energy is applied using an external energy source directed at the area of interest to disrupt at least a portion of a tissue located at the area of interest. The disrupted tissue is removed from the gastrointestinal lumen.

Abstract: A method, therapeutic probe, and system for treating a tissue margin surrounding an interstitial cavity is provided. The interstitial cavity may be created by resecting tissue, e.g., malignant tissue, from the patient's body to create the interstitial cavity. The interstitial cavity may assume any shape, but in a typical method, the interstitial cavity is spherically shaped. An expandable hyperthermic body of the therapeutic probe is expanded within the interstitial cavity into contact with the tissue margin. The tissue margin is heated with the hyperthermic body, and therapeutic x-ray radiation is conveyed from the hyperthermic body into the tissue margin. Heating of the tissue margin with the hypothermic body may ablate the tissue margin.

Abstract: An apparatus for use in a tissue ablation procedure includes a base, a fluid delivery tube coupled to the base, a first lever rotatably coupled to the base, the first lever having a first end biased to press against a portion of the fluid delivery tube to thereby close a lumen within the fluid delivery tube, and a second end, and a securing mechanism for securing the base relative to an ablation device. An ablation system includes an ablation device having an electrode, a fluid delivery tube coupled to the ablation device, and a control for simultaneously activating the electrode and opening the fluid delivery tube. A method of performing tissue ablation includes operating a control to activate an electrode, thereby delivering ablation energy to target tissue, wherein the step of operating the control also causes fluid to be delivered to the target tissue.

Abstract: Assemblies and methods are provided for resecting a portion of tissue to be removed (e.g., unhealthy tissue, such as cancerous tissue) from a portion of the tissue to be retained (e.g., healthy tissue) within a patient is provided. An electrically conductive fluid, such as saline, may be absorbed into a hydrophilic electrode. Electrical energy (e.g., radio frequency (RF) energy) is conveyed to or from the hydrophilic electrode while being moved in proximity to the tissue along a resection line, whereby tissue adjacent to the resection line is coagulated. A resection member, such as a blunt resection member or a resection electrode, which may be on the same device as the hydrophilic electrode, is used to separate the tissue along the resection line to resect the tissue portion to be removed from the tissue portion to be retained.

Abstract: A vessel occlusion apparatus includes an elongate shaft having a fluid delivery lumen; and an expandable member carried on a distal end portion of the shaft, the expandable member comprising a body defining an interior region, the interior region in communication with the fluid delivery lumen, the body comprising a wall having one or more embedded fluid pockets therein, each of the one or more pockets containing a fluid capable of being imaged, e.g., having echogenic qualities for detection using ultrasound imaging.

Abstract: A system and method for treating a target tissue region (e.g., malignant tissue) is provided. A hyperthermic probe is placed into contact with the target tissue region, and the target tissue region is exposed to a therapeutic x-ray radiation beam. The probe is operated to increase the temperature of the target tissue region, thereby facilitating a therapeutic effect of the radiation beam. Image data of the probe containing a fiducial datum is acquired while in contact with the target tissue region, a position of the target tissue region within a treatment coordinate system is determined based on the fiducial datum, and the radiation beam is spatially adjusted relative to the target tissue region based on the determined position of the target tissue region.

Abstract: Ablation probes are provided for perfusing the tissue, while the tissue is ablated. The ablation probe comprises an elongated shaft and an ablative element, such as a needle electrode. The ablation probe further comprises a lumen that extends through the probe shaft, which will be used to deliver an fluid to the distal end of the probe shaft for perfusion into the surrounding tissue. The ablation probe further comprises a porous structure that is associated with the distal end of the shaft in fluid communication with the lumen. For example, the distal end of the shaft, or the entirety of the shaft, can be composed of the porous structure. Or, if the ablative element is an electrode, the electrode can be composed of the porous structure. Because the pores within the porous structure are pervasive, the fluid will freely flow out into the tissue notwithstanding that some of the pores may become clogged.

Abstract: A system for resecting tissue includes a loop structure configured for cutting tissue, at least a portion of the loop structure formed by an elongate structure having a first end and a second end, wherein a length of the loop structure is adjustable by positioning the first end relative to the second end, wherein a first portion of the loop structure comprises a first electrode, and a second portion of the loop structure comprises a second electrode. A system for resecting tissue includes a loop structure configured for cutting tissue, the loop structure formed by an elongate structure having a first end and a second end, wherein a length of the loop structure is adjustable by positioning the first end relative to the second end, and a support structure coupled to a portion of the elongate structure and having a surface for contacting tissue.

Abstract: An apparatus includes an elongate body including a proximal end portion and a distal end portion and configured to be at least partially inserted into a body cavity. The elongate body defines a first passageway and a second passageway. The first passageway is configured to communicate fluid from the distal end portion in a first direction, and the second passageway is configured to communicate material from outside of the elongate body into the distal end portion in a second direction opposite the first direction and includes at least one port. An actuator is coupled to the elongate body and is configured to guide the distal end of the elongate body to an area of interest identifiable by a virtual colonoscopy.

Abstract: Methods, probe assemblies and systems are provided for treating tissue a margins surrounding interstitial spaces created via the removal of tumors. The interstitial space may be in any tissue, e.g., breast tissue, and the interstitial space may be created by removing abnormal tissue. A hydrophilic electrode is compressed and introduced (e.g., percutaneously) into the interstitial cavity. An electrically conductive liquid (e.g., saline) is applied to the electrode, such that the electrode absorbs the electrically conductive liquid. The electrode is expanded into contact with the tissue margin, and electrical energy (e.g., radio frequency (RF) energy) is conveyed to the electrode, thereby ablating the tissue margin.