Abstract: A cushioning and impact absorbing pad with a surface layer of thickness t, and an elastomeric sub-surface-structure of height h. The sub-surface structure comprises an array of elastomeric columns wherein each column has a frustoconical column wall surrounding a central void. The frustoconical column walls have a zone that is a more compressible, relatively collapsible zone in a region at an end of the column opposite the surface layer and a zone that is a relatively less compressible zone in a region at the end of the column abutting the surface layer. Column walls are tapered with draft angles in the range of greater than 6 degrees and less than 10 degrees.

Abstract: A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-? inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.

Abstract: A motion control assembly includes a motion control device electrically connected to a battery pack and to a mobile computing device for at least data transmission therebetween. The motion control device can generate inputs, such as inputs corresponding to an attribute of a sensed object, for transmission to the mobile computing device. The drain on a battery of a battery-powered mobile computing device can be reduced when used with a motion control device as follows. A motion control assembly, comprising a motion control device and a battery pack, capable of powering the motion control device, as an integral, one-piece unit, is selected. The motion control device is connected to an electrical connector of a battery-powered mobile computing device. The motion control device is supplied with power from the battery pack during use so the motion control device can be operated using the power from the battery pack.

Abstract: Precursors and methods for manufacturing perforated composite parts are disclosed. An exemplary precursor (19) comprises structural fibres (24,28) embedded in a cured matrix material (24,26) and interposed between two removable plies (20). The precursor may also comprise a sacrificial fibre (28) extending through the removable plies (20), the matrix material (24,26) and between the structural fibres (24,28). An exemplary method comprises removing the removable plies (20) from the precursor (19) and removing the sacrificial fibre (28) from the precursor after removing the removable plies to form a through hole in the precursor (19) at a location of the sacrificial fibre (28).

Abstract: The technology disclosed can provide improved safety by detecting potential unsafe conditions (e.g., collisions, loss of situational awareness, etc.) confronting the user of a wearable (or portable) sensor configured to capture motion and/or determining the path of an object based on imaging, acoustic or vibrational waves. Implementations can enable improved safety to users of virtual reality for machine control and/or machine communications applications using wearable (or portable) devices, e.g., head mounted displays (HMDs), wearable goggles, watch computers, smartphones, and so forth, or mobile devices, e.g., autonomous and semi-autonomous robots, factory floor material handling systems, autonomous mass-transit vehicles, automobiles (human or machine driven), and so forth, equipped with suitable sensors and processors employing optical, audio or vibrational detection.

Abstract: A method for evaluating and optimizing complex fractures, in one non-limiting example far-field complex fractures, in subterranean shale reservoirs significantly simplifies how to generate far-field fractures and their treatment designs to increase or optimize complexity. The process gives information on how much complexity is generated for a given reservoir versus distance from the wellbore under known fracturing parameters, such as rate, volume and viscosity. The method allows the evaluation of the performance of diversion materials and processes by determining the amount of fracture volume generated off of primary fractures, including far-field secondary fracture volumes. The methodology utilizes fracture hit times, volumes, pressures and similar parameters from injecting fracturing fluid from a first primary lateral wellbore to create fractures and record fracture hit times, pressures and volumes from a diagnostic lateral wellbore in the same interval.

Abstract: Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising a Nav1.7 selective inhibitor and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in a subject are also disclosed herein.

Abstract: A motion control assembly includes a motion control device electrically connected to a battery pack and to a mobile computing device for at least data transmission therebetween. The motion control device can generate inputs, such as inputs corresponding to an attribute of a sensed object, for transmission to the mobile computing device. The drain on a battery of a battery-powered mobile computing device can be reduced when used with a motion control device as follows. A motion control assembly, comprising a motion control device and a battery pack, capable of powering the motion control device, as an integral, one-piece unit, is selected. The motion control device is connected to an electrical connector of a battery-powered mobile computing device. The motion control device is supplied with power from the battery pack during use so the motion control device can be operated using the power from the battery pack.

Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.

Abstract: A wall-mountable material dispensing system includes a material dispenser having a back wall, a bottom surface, a first element of an engagement component, and a self-alignment receiver, and a mounting bracket. The mounting bracket includes a baseplate having a generally planar wall-facing surface and an opposite outward-facing surface, a self-alignment protrusion extending from the outward-facing surface, wherein the self-alignment receiver is sized to at least partially receive the self-alignment protrusion. The mounting bracket also includes a second element of the engagement component configured to engage with the first element of the engagement component, wherein the second element of the engagement component is disposed on or in the outward-facing surface, a support member extending from or adjacent to the outward-facing surface, and a wall-mounting mechanism disposed on or adjacent to the wall-facing surface.

Abstract: Described herein are systems and methods for transmucosal delivery of active agents. In some embodiments, a system may comprise one or more mucoadhesive devices configured for release of an active agent.

Abstract: Embodiments of the disclosure provide a method for aggregating and providing health data records to an electronic device. The method is performed by a server that includes a processor and a non-transitory computer readable medium with processor-executable instructions stored thereon. When the instructions are executed by the processor, the server performs the method including: (a) receiving collected data from one or more client devices, the collected data comprising health related data including at least one of step count data, heart rate data, sleep sensor data; (b) extracting metadata from the collected data; (c) pseudonymizing the collected data; (d) categorizing the collected data using the extracted metadata and enterprise ontology of the server; and (e) storing the collected data.

Abstract: Described herein is a control system that facilitates assistance mode(s). In particular, the control system may determine a particular assistance mode associated with an account. This particular assistance mode may specify (i) operations for an aerial vehicle to carry out in order to obtain sensor data providing environment information corresponding to a location associated with the account and (ii) feedback processes to provide feedback, via a feedback system associated with the account, that corresponds to respective environment information. The control system may transmit to the aerial vehicle an indication of the particular operations corresponding to the particular assistance mode and may then receive environment information for the location associated with the account. Based on the received environment information, the control system may apply the specified feedback processes to initiate feedback in accordance with the particular assistance mode via the associated feedback system.

Abstract: A control rod for incorporation into a composite assembly with at least a first composite preform, a second composite preform, and a cured resin includes a shaft defining an axis, wherein the shaft is disposable within an aperture in the composite assembly, and a plurality of threads disposed on at least a portion of the shaft. The shaft is made from, among other materials, a thermoplastic material. The threads define a thread pitch that encompasses more than one individual fiber layer forming at least one of the first composite layer and the second composite layer.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for presenting content on tearable displays. One of the methods includes presenting, by a device having a tearable display, first content on the tearable display; receiving, at the device, an indication of a tear in the tearable display, the tear in the tearable display defining a first portion and a second portion of the tearable display; in response to receiving the indication, determining, by the device, a size of the second portion of the tearable display; and presenting, by the device, second content within the second portion of the tearable display including sizing the second content according to the size of the second portion of the tearable display.

Abstract: Improving the knowledge about how hydraulic fracture networks are generated in subsurface shale volumes in unconventional wellbores may be accomplished with various configurations of at least one diagnostic lateral wellbore using at least one diagnostic device disposed in the diagnostic lateral wellbore. By extending diagnostic lateral wellbores from adjacent lateral wellbores and/or separately drilling diagnostic lateral wellbores, and analyzing signals received by diagnostic devices placed in the diagnostic lateral wellbores, knowledge about fracture networks, the parameters that control fracture geometry and reservoir production and how reservoirs react to refracturing techniques may be greatly improved. Additionally, such diagnostic lateral wellbores can provide quicker location of sweet-spot horizons in reservoirs.

Abstract: A systems and methods for managing a plurality of service provider transactions within an auction/delivery services marketplace defined by multiple rapidly changing criteria is provided. The present invention regularly tests and tracks in real time the available service providers within the auction/delivery to determine their rates of successfully delivering their provided services.

Abstract: Improving the flow of hydrocarbons from shale lateral wellbores in unconventional wellbores may be accomplished with various configurations of assisting lateral wellbores and/or kick-off wellbores from primary lateral wellbores and/or secondary or assisting lateral wellbores. By extending fracture networks from adjacent lateral wellbores and/or adjacent kick-off wellbores so that the fracture networks from different wellbores are in fluid communication with one another, the flow of various fluids between the adjacent wellbores provides another dimension of control over the wellbores and fracture networks used to recover hydrocarbons from the shale intervals of interest.

Abstract: One embodiment relates to a computer-implemented method for role discovery in access control systems. User accounts are selected according to a predetermined algorithm. For each selected user account, a new role is created covering a set of permissions including all permissions which the user account needs but is not yet covered by another role that the user account has. The new role is given to the user account so that all permissions needed by the user account are covered. Any additional user accounts which still need the set of permissions covered by the new role are also found, and the new role is given to these additional user accounts, if any. Other features, aspects and embodiments are also disclosed.

Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. A single layer of epithelial cells that actively self-renews and is organized into crypts and villi clothes the intestine. It has been recently shown that the renewal of intestinal epithelium is driven by Lgr5+ intestinal stem cells (ISC) that reside at the base of these crypts (Barker et al., 2007). Lgr5+ stem cells can be isolated and cultured in vitro to form organoids containing crypt-vcllus structures that recapitulates the native intestinal epithelium (Sato et al., 2009).