Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.

Abstract: A motion control assembly includes a motion control device electrically connected to a battery pack and to a mobile computing device for at least data transmission therebetween. The motion control device can generate inputs, such as inputs corresponding to an attribute of a sensed object, for transmission to the mobile computing device. The drain on a battery of a battery-powered mobile computing device can be reduced when used with a motion control device as follows. A motion control assembly, comprising a motion control device and a battery pack, capable of powering the motion control device, as an integral, one-piece unit, is selected. The motion control device is connected to an electrical connector of a battery-powered mobile computing device. The motion control device is supplied with power from the battery pack during use so the motion control device can be operated using the power from the battery pack.

Abstract: Diagnostic or assisting lateral wellbores can have a significant benefit for injecting and distributing treatment fluids and other materials within complex fracture networks that surpass conventional injection at the primary lateral wellbore perforations for acquiring empirical knowledge about the numerous processes that influence shale reservoir production which occur after primary shale reservoir stimulation. Injection of diagnostic treatment fluids or treating chemicals for understanding production optimization, such as water-block removal, fines migration removal, and treating chemicals for prevention of scale and paraffin deposition, can be injected along the diagnostic lateral wellbore or frac interval lateral wellbores to give broader and/or deeper distribution into the fracture network than by using mono-bore-centric diagnostic injection techniques.

Abstract: An electronic fuel injection system for land vehicles, comprising: a fuel tank, at least one pump, a fuel sump, wherein the at least one pump is operatively coupled to and between the fuel tank and the sump, and an engine, wherein the engine is operatively coupled to the fuel sump. A fuel sump system for land vehicles, comprising: an inlet from a pump, wherein the pump is operatively connected to a fuel tank, a fuel pump system, a regulator operatively coupled to the fuel pump system, an outlet operatively coupled to an engine, and a float component, coupled to the inlet. An electronic fuel injection system for land vehicles, comprising: a fuel tank, at least one pump, a fuel sump, wherein the at least one pump is operatively coupled to and between the fuel tank and the sump, and an engine, wherein the engine is operatively coupled to the fuel sump and wherein the electronic fuel injection system does not require a return line from the engine to the fuel tank.

Abstract: Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising a Nav1.7 selective inhibitor and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein.

Abstract: The example embodiments are directed to a device and method for matching together aircraft status reports. In one example, the method includes detecting, via a user interface, a selection of an aircraft from among a plurality of aircraft that have provided aircraft status reports, determining a group of aircraft status reports, from among the received status reports, which were generated by the respective aircraft during a flight of the respective aircraft, based on metadata of the received aircraft status reports, and displaying, via the user interface, the group of aircraft status reports determined to be provided by the respective aircraft during the flight. By linking together status reports from an entire flight, analysis may be performed on data from across an entire flight instead of an individual status report thereby improving flight data analysis and subsequent actions taken based on that analysis.

Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.

Abstract: The technology disclosed can provide improved safety by detecting potential unsafe conditions (e.g., collisions, loss of situational awareness, etc.) confronting the user of a wearable (or portable) sensor configured to capture motion and/or determining the path of an object based on imaging, acoustic or vibrational waves. Implementations can enable improved safety to users of virtual reality for machine control and/or machine communications applications using wearable (or portable) devices, e.g., head mounted displays (HMDs), wearable goggles, watch computers, smartphones, and so forth, or mobile devices, e.g., autonomous and semi-autonomous robots, factory floor material handling systems, autonomous mass-transit vehicles, automobiles (human or machine driven), and so forth, equipped with suitable sensors and processors employing optical, audio or vibrational detection.

Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. A single layer of epithelial cells that actively self-renews and is organized into crypts and villi clothes the intestine. It has been recently shown that the renewal of intestinal epithelium is driven by Lgr5+ intestinal stem cells (ISC) that reside at the base of these crypts (Barker et al., 2007). Lgr5+ stem cells can be isolated and cultured in vitro to form organoids containing crypt-vcllus structures that recapitulates the native intestinal epithelium (Sato et al., 2009).

Abstract: Systems, tools, and methods for optimizing fracturing schedules located along a horizontal wellbore include obtaining drilling cuttings during a drilling operation representative of a predetermined interval of the horizontal wellbore, performing at least one analytical process on the obtained drilling cuttings to determine at least one geomechanical property of the interval of the obtained drilling cuttings for the interval, generating a formation analysis estimation for the interval from the, wherein the formation analysis estimation comprises at least one of (i) a brittleness of the formation at the interval or (ii) a minimum horizontal stress of the formation at the interval, and based on the formation analysis estimation, at least one of (i) configuring a super-stage for deployment to the interval to perform a fracturing operation or (ii) designing a fracturing schedule to be performed to frac the formation at the interval.

Abstract: A tracking and accountability system and apparatus is provided and comprises a command unit and processing unit coupled to a wireless communication network, a first tracking device having a first mobile transceiver in communication with the wireless communication network and coupled to a first set of identification data of a first individual and being operative to transmit signals representing the first individual's location over the wireless communication network to the processing unit, and a second tracking device having a second mobile transceiver and coupled to a second set of identification data of a second individual and being operative to transmit signals representing the second individual's location (i) to the processing unit over the wireless communication network if the second tracking device is within a first distance; and (ii) to the first tracking device if the second tracking device is within the first distance to the first tracking device.

Abstract: The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or Cas system components. Compositions comprising modified ribonucleic acids have been designed with chemical modification for even higher efficiency as unmodified native strand of sgRNA. Administration of modified ribonucleic acids will allow decreased immune response when administered to a subject, increased stability, increased editing efficiency and facilitated in vivo delivery of sgRNA via various delivery platforms. The disclosure also relates to methods of decreasing off-target effect of CRISPR and a CRISPR complex.

Abstract: The example embodiments are directed to a device and method for matching together aircraft status reports. In one example, the method includes detecting, via a user interface, a selection of an aircraft from among a plurality of aircraft that have provided aircraft status reports, determining a group of aircraft status reports, from among the received status reports, which were generated by the respective aircraft during a flight of the respective aircraft, based on metadata of the received aircraft status reports, and displaying, via the user interface, the group of aircraft status reports determined to be provided by the respective aircraft during the flight. By linking together status reports from an entire flight, analysis may be performed on data from across an entire flight instead of an individual status report thereby improving flight data analysis and subsequent actions taken based on that analysis.

Abstract: Described herein are systems and methods for transmucosal delivery of active agents. In some embodiments, a system may comprise one or more mucoadhesive devices configured for release of an active agent.

Abstract: An embodiment of the disclosure provides a method of integrating data across multiple data stores in a smart cache in order to provide data to one or more recipient systems. The method includes automatically ingesting diverse data from multiple data sources, automatically reconciling the ingested diverse data by updating semantic models based on the ingested diverse data, storing the ingested diverse data based on one or more classification of the data sources according to the semantic models, automatically generating scalable service endpoints which are semantically consistent according to the classification of the data sources, and responding to a call from the one or more recipient systems by providing data in the classification of the data sources.

Abstract: A cushioning and impact absorbing pad system with a surface layer of thickness t, and an elastomeric sub-surface structure of height h. The sub-surface structure comprises an array of elastomeric columns wherein each column has a frustoconical column wall surrounding a central void. The frustoconical column walls have a zone that is a more compressible, relatively collapsible zone in a region at an end of the column opposite the surface layer and a zone that is a relatively less compressible zone in a region at the end of the column abutting the surface layer. In other embodiments, pad thickness and column height are variable to create a surface which follows the contours of a human body.

Abstract: A system and method for controlling business processes through information technology operational controls are disclosed. The method includes: receiving a business process; monitoring a load at each of multiple layers of the system; sending, to an end-to-end throttle controller, for each layer of the multiple layers, layer load data corresponding to the load at the layer, wherein each layer load data contains data related to a single layer; determining whether any adjustments should be made to throttling policies corresponding to the multiple layers based on the multiple layer load data; sending any adjustments that should be made to throttle agents of one or more layers; updating the throttling policies of one or more layers based on the adjustments; and, continuing executing the business process based on the updated throttling policies.

Abstract: The technology disclosed relates to an embeddable motion sensory control device that detects gestures in a three dimensional (3D) sensory space within a vehicle cabin, detecting a gesture in the 3D sensory space and interpreting the gesture as a command to a (sub) system of the vehicle under control, and issuing the command when appropriate.

Abstract: The technology disclosed can provide improved safety by detecting potential unsafe conditions (e.g., collisions, loss of situational awareness, etc.) confronting the user of a wearable (or portable) sensor configured to capture motion and/or determining the path of an object based on imaging, acoustic or vibrational waves. Implementations can enable improved safety to users of virtual reality for machine control and/or machine communications applications using wearable (or portable) devices, e.g., head mounted displays (HMDs), wearable goggles, watch computers, smartphones, and so forth, or mobile devices, e.g., autonomous and semi-autonomous robots, factory floor material handling systems, autonomous mass-transit vehicles, automobiles (human or machine driven), and so forth, equipped with suitable sensors and processors employing optical, audio or vibrational detection.

Abstract: A tracking and accountability system and apparatus is provided and comprises a command unit and processing unit coupled to a wireless communication network, a first tracking device having a first mobile transceiver in communication with the wireless communication network and coupled to a first set of identification data of a first individual and being operative to transmit signals representing the first individual's location over the wireless communication network to the processing unit, and a second tracking device having a second mobile transceiver and coupled to a second set of identification data of a second individual and being operative to transmit signals representing the second individual's location (i) to the processing unit over the wireless communication network if the second tracking device is within a first distance; and (ii) to the first tracking device if the second tracking device is within the first distance to the first tracking device.