Abstract: The present invention relates to therapeutic protocols and pharmaceutical compositions designed to treat and prevent cancer. More specifically the present invention relates to a novel method of treating cancer using antagonists to the endothelin B receptor (ETB) or inactive mimic forms of endothelin-1. The pharmaceutical compositions of the invention are capable of selectively inhibiting the early events associated with the development of cancer. The present invention further relates to screening assays to identify compounds which inhibit ETB activation.

Abstract: A method and apparatus for performing an open wedge osteotomy utilizing a keyed, wedge-shaped implant for disposition in a keyed, wedge-shaped opening created in a bone. The keys may be disposed in vertical or horizontal arrangements. In addition, a shear rib key hole may be formed adjacent the wedge-shaped opening in the bone.

Abstract: A tamper-protected electronic module comprises a printed circuit board having a first side, on which electronic components of an electronic circuit including at least one microchip are located, and a housing cover that is facing the first side of the printed circuit board. The housing cover has, on the inside thereof, a sealed inner frame that extends to the first side of the printed circuit board and surrounds only a security-relevant portion of the electronic circuit including the microchip. The volume enclosed by the inner frame between the first side of the printed circuit board and the housing cover is filled with a casting resin under formation of a coherent casting compound.

Abstract: A method of reducing data transfer while increasing image information over an 802.15.4 network includes obtaining an image with a sensor, modulating a representation of the image using a first 802.15.4 modem, sending the representation of the image to a coordinator, demodulating the representation of the image using a second 802.15.4 modem, and digitally enhancing at least one of the representation of the image and the image. A system for communication over an 802.15.4 network includes a sensor for obtaining data, the size of the data being at least an order of magnitude greater than the size of an 802.15.4 packet, a first 802.15.4 modem coupled to the sensor, a buffer for temporarily storing the data to allow transmission of portions of the data; the buffer being coupled to the sensor, a coordinator coupled to the sensor, the coordinator being capable of communicating with a computer, and a second 802.15.4 modem coupled to the coordinator.

Abstract: An overhead or ceiling-mounted storage system is disclosed. The system includes two or more rails. A rail includes one or more lips that may support a bin. The bin includes substantially straight opposing walls topped with a rim or other structure that may contact the lip of a rail. The rails may support the bin when the rim is placed on the rails and the rails are attached to an overhead structure, such as a ceiling. The lips of the rails and the rims of the bins are configured such that the lips substantially maintain contact with the rims across each of their respective widths.

Abstract: A method of reducing data transfer while increasing image information over an 802.15.4 network includes obtaining an image with a sensor, modulating a representation of the image using a first 802.15.4 modem, sending the representation of the image to a coordinator, demodulating the representation of the image using a second 802.15.4 modem, and digitally enhancing at least one of the representation of the image and the image. A system for communication over an 802.15.4 network includes a sensor for obtaining data, the size of the data being at least an order of magnitude greater than the size of an 802.15.4 packet, a first 802.15.4 modem coupled to the sensor, a buffer for temporarily storing the data to allow transmission of portions of the data; the buffer being coupled to the sensor, a coordinator coupled to the sensor, the coordinator being capable of communicating with a computer, and a second 802.15.4 modem coupled to the coordinator.

Abstract: An apparatus and method for performing an open wedge osteotomy. The apparatus includes devices for forming an open wedge osteotomy in bone, including a keyed-wedge implant. The method includes the steps of forming a cut in a bone, forming a keyhole in the bone surface at the proximal end of the cut, and positioning a keyed wedge-shaped implant into the cut formed into the bone.

Abstract: An apparatus and method for performing an open wedge osteotomy. The apparatus includes devices for forming an open wedge osteotomy in bone, including a keyed-wedge implant. The method includes the steps of forming a cut in a bone, forming a keyhole in the bone surface at the proximal end of the cut, and positioning a keyed wedge-shaped implant into the cut formed into the bone.

Abstract: A system and method for assessing failure of fuel rods are disclosed. The method may include monitoring fuel rod operational conditions, comparing the fuel rod parameters to parameters limits, calculating the fuel rod performance parameters to determine the likelihood of failure of individual fuel rods, and updating plant operating parameters based on the calculated fuel rod parameters. The system may input the calculated fuel rod parameters into a fuel failure model to assess the probability of failure, and predict the probability of failure of individual fuel rods based on fuel rod parameters in the fuel failure model.

Abstract: A method for direction finding by means of monopulse formation in a radar system with electronically controlled group antenna and analog beam shaping of sum and difference channels, a self-test of the antenna being carried out to identify failed receiving elements, and the result of the self-test going directly into the monopulse formation and the test thereby being error corrected. The result of the self-test is converted into correction values that, independently of the antenna viewing direction, are combined with those from the sum channel signal and the difference channel signals of the antenna.

Abstract: An osteotomy implant for disposition in a wedge-shaped osteotomy opening in a bone, the implant comprising: a body for disposition within the wedge-shaped osteotomy opening in the bone and supporting the bone while healing occurs; at least one key formed integral with the body for stabilizing the body relative to the adjacent bone while healing occurs; and at least one fenestration extending through the body for permitting bone growth through the implant.

Abstract: Apparatus for performing an open wedge, high tibial osteotomy, the apparatus comprising: cutting apparatus for forming an osteotomy cut in the tibia, the cutting apparatus comprising: targeting apparatus for identifying a cutting plane through the tibia and a boundary line for terminating a cut made along the cutting plane, wherein the boundary line is located within the tibia, parallel to the anterior-posterior slope of the tibia and parallel to the sagittal plane of the patient.

Abstract: A method and apparatus for performing an open wedge osteotomy utilizing a keyed, wedge-shaped implant for disposition in a keyed, wedge-shaped opening created in a bone. The keys may be disposed in vertical or horizontal arrangements. In addition, a shear rib key hole may be formed adjacent the wedge-shaped opening in the bone.

Abstract: A method for sampling volume data of an object in an imaging device is disclosed. The method includes creating a voxel dataset of a first volume associated with the object using a scanning device and saving the voxel dataset; defining a grid of sampling positions by casting rays through the first volume and choosing a number of points along a respective ray; choosing a sampling access pattern that defines a sequence of the sampling positions; selecting an interpolation scheme mapping the sampling access pattern to a voxel access pattern defining a sequence of the voxels of the voxel dataset; successively loading memory lines of a main memory comprising the data associated with the respective voxel into a cache memory if the memory line is not already present in the cache memory; and processing the data associated with the respective voxel, the cache memory access being optimized for rendering time performance.

Abstract: A method of reducing data transfer while increasing image information over an 802.15.4 network includes obtaining an image with a sensor, modulating a representation of the image using a first 802.15.4 modem, sending the representation of the image to a coordinator, demodulating the representation of the image using a second 802.15.4 modem, and digitally enhancing at least one of the representation of the image and the image. A system for communication over an 802.15.4 network includes a sensor for obtaining data, the size of the data being at least an order of magnitude greater than the size of an 802.15.4 packet, a first 802.15.4 modem coupled to the sensor, a buffer for temporarily storing the data to allow transmission of portions of the data; the buffer being coupled to the sensor, a coordinator coupled to the sensor, the coordinator being capable of communicating with a computer, and a second 802.15.4 modem coupled to the coordinator.

Abstract: Methods for detecting the flight path of projectiles involve a sequence of N target detections that include detecting the measured velocities and azimuthal angle bearings of the projectile along the flight path of the projectile by Doppler radar at the times tn, wherein n=1 . . . N, and determining the flight path and the direction of motion of the projectile are from these measurements. The measurements are adapted in a first nonlinear parameter fit to an analytical relationship of the time curve of the radial velocity of the projectile while the projectile passes through the detection range of the radar and so that the absolute projectile velocity, minimum distance of the project flight path from the radar, time at which the projectile passes the point having the minimum distance, flight path direction in azimuth, and flight path direction in elevation can be estimated.

Abstract: The present invention relates to therapeutic protocols and pharmaceutical compositions designed to treat and prevent cancer. More specifically, the present invention relates to a novel method of treating cancer using antagonists to the endothelin B receptor (ETB) or inactive mimic forms of endothelin-1. The pharmaceutical compositions of the invention are capable of selectively inhibiting the early events associated with the development of cancer. The present invention further relates to screening assays to identify compounds which inhibit ETB activation.

Abstract: The present invention relates to therapeutic protocols and pharmaceutical compositions designed to treat and prevent cancer. More specifically the present invention relates to a novel method of treating cancer using antagonists to the endothelin B receptor (ETB) or inactive mimic forms of endothelin-1. The pharmaceutical compositions of the invention are capable of selectively inhibiting the early events associated with the development of cancer. The present invention further relates to screening assays to identify compounds which inhibit ETB activation.

Abstract: A method, system and product are disclosed for volume rendering of medical images on a shared memory system implemented on a multi-socket mainboard with multiple multi-core processors and multiple last level caches, cores that share a cache being united in a socket. The method includes decomposing the image space to be used for rendering in regions, each region including a plurality of tiles; assigning two sockets to each of the decomposed regions; determining a tile enumeration scheme for a region; rendering all tiles within a region according to a determined tile enumeration scheme on the assigned two sockets until the respective region is finished; if a region is finished, assigning the two sockets to another region; and if no region is left, splitting an existing region of un-rendered tiles into sub-regions according to a splitting scheme and applying the steps recursively for the sub-regions.