Abstract: A method of deploying a plurality of spacecraft includes coupling the plurality of spacecraft in a stack to a payload adaptor, the stack extending along a longitudinal axis; launching the payload adaptor into an orbit; and decoupling an entirety of the stack from the payload adaptor after the payload adaptor reaches the orbit.

Abstract: Various embodiments of the systems, methods and devices are provided for breaking up calcified lesions in an anatomical conduit. More specifically, an electrical arc is generated between two spaced-apart electrodes disposed within a fluid-filled balloon, creating a subsonic pressure wave. In some embodiments, the electrodes comprise a plurality of points or extensions that allow the electrical arc to form at any one of the plurality of points to, among other things, extend the electrode life.

Abstract: The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.

Abstract: This disclosure describes a variety of transitional or terminal components that may be implanted as part of a spinal fixation construct to decrease the potential for subsequent development of junctional disease. The fixation construct may extend any number of levels from a single level construct to a long construct spanning multiple spinal levels and multiple spinal regions from the lumbosacral to cervical regions, and with any variety of combination of anchors, rods, and connectors. Terminal and/or transitional components maybe utilized at the caudal and or cephalad ends of the fixation construct to reduce stresses endured by the construct adjacent pathology and prevent or reduce incidence and degree of junctional disease.

Abstract: The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound (I), Compound (IA) and Compound (IB), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.

Abstract: Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.

Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.

Abstract: This invention relates to compounds of general Formula I and pharmaceutically acceptable salts thereof, in which R1, R2, R3a, R3b, and R4 are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A method of making copper (I) 5-nitrotetrazolate (DBX-1) in isolated form comprising: a) reacting bis(ethylenediamine) copper (II) nitrotetrazolate with nitric acid or sulfuric acid to form a reaction product, subsequently b) reducing the reaction product of a) with ascorbate or ascorbic acid and reacting with copper chloride or copper sulfate to form copper (I) 5-nitrotetrazolate, and subsequently isolating the copper (I) 5-nitrotetrazolate (DBX-1) as a precipitate. The copper (I) 5-nitrotetrazolate produced by said method is useful as a primary explosive.

Abstract: The present disclosure relates to oral compositions of Compound I or a derivative thereof. Methods of use for treating an inflammatory condition are also disclosed.

Abstract: Disclosed herein are oligosaccharides and intermediates useful for the production thereof. The compounds are useful as analytical standards and as intermediates for the preparation of more complex oligosaccharide and N-glycan products. The compounds may be prepared in high purity using the selective stop/go synthetic methods disclosed herein.

Abstract: Systems for post-processing additively manufactured objects are disclosed herein. In some embodiments, a system includes a rotor configured to support a plurality of additively manufactured objects having excess material thereon, an actuator configured to spin the rotor so as to remove the excess material from the plurality of additively manufactured objects, and an energy source configured to apply energy to the plurality of additively manufactured objects to selectively alter a material property of a portion of each of the plurality of additively manufactured objects.

Abstract: Included herein are manufacturing methods relating to water soluble non-fibrous substrates with particles and an apparatus to place the particles on the water soluble non-fibrous substrate.

Abstract: According to some embodiments, an interface assembly for coupling an orthogonal circuit board to a main circuit board includes a frame, signal pins, and dielectric retainers. The frame is electrically coupled to a ground signal of the orthogonal circuit board. The dielectric retainers electrically isolate the plurality of signal pins from the frame. The frame includes an interface surface configured to electrically couple the frame to a plurality of ground spring pins of a spring interposer of the main circuit board. Each particular signal pin of the interface assembly includes a pin head configured to electrically couple the particular signal pin to a particular one of a plurality of signal spring pins of the spring interposer. The interface surface of the frame and the pin heads of the plurality of signal pins form a coplanar surface.

Abstract: A construction board comprising a foam layer, an pressure-sensitive adhesive layer that is at least partially cured, and a release liner.

Abstract: Provided is a method for training a hypernetwork to provide a policy for use on a previously-unseen task. The hypernetwork may be trained at a robot factory and then shipped with a robot. At the point of deployment, the robot may be given a context for the previously-unseen task. The robot then uses the context and the hypernetwork to create a policy for performing the previously-unseen task. The policy represents an artificial intelligence machine generated for the previously-unseen task.

Abstract: A system has been developed to facilitate hands-free autonomous control of material handling equipment or vehicles, such as forklifts and pallet trucks. The system has been designed to facilitate visual tracking by the automated vehicle and further facilitates voice commands. In some use cases, visual tracking is only used, and in other cases only voice commands are used. In other cases, both visual tracking and voice commands are used to control the material handling vehicle. For visual tracking, one or more cameras are configured to capture one or more images of a fiducial. In one case, the vehicle moves, turns, and/or stops based on the movement of the fiducial. For voice control, the operator provides voice commands via a voice controller. The voice controller converts the voice commands to vehicle control commands that are sent to a remote receiver unit (RRU) in the vehicle.

Abstract: Technologies and techniques for annotating images of an object captured using a camera, wherein the camera is positioned on a robot arm, and wherein the robot arm includes an end effector. A position and an orientation of the camera is determined, relative to the end effector, and a first keypoint is selected on the object. Information regarding additional keypoints relative to the first keypoint is provided in object coordinates, and the end effector is guided to the position of the first keypoint. The position and the orientation of the end effector is determined at the first keypoint, and based on other determined world coordinates, the position and/or the orientation of the end effector is changed based on converted camera image coordinates.

Abstract: The present disclosure is directed to a method to co-synthesize amorphous and crystalline porous materials, including a phase of crystalline solids possessing well-defined structures and uniform pore sizes, and an amorphous phase. A sol-gel formulation which includes a water-soluble fraction of ODSO as an additional component is provided that precipitates multiple solid phases.

Abstract: A trailer hitch system for equalizing trailer loads and reducing trailer sway. The trailer hitch system may include spring bars that may be attached to a hitch head using a trunnion style connection. The spring bars may be attached to the trailer using rigid brackets that reduce swinging of the spring bars. The rigid brackets having a plurality of contact points may include an upward extending portion for attaching to the trailer tongue, and a lateral extending portion for receiving the spring bars thereupon. The rigid brackets may include a spacing member and an attachment member.