Patents by Inventor Robert Zahler

Robert Zahler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutically active compounds and their methods of use
    Patent number: 10172864
    Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: January 8, 2019
    Assignee: Agios Pharmaceuticals, Inc.
    Inventors: Zenon D. Konteatis, Janeta Popovici-Muller, Jeremy M. Travins, Robert Zahler, Zhenwei Cai, Ding Zhou
  • Compositions and methods utilizing lysophosphatidylcholine scaffolds
    Patent number: 10175256
    Abstract: The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: January 8, 2019
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: David Lawrence Silver, Nam Long Nguyen, Robert Zahler
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20190002398
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: January 29, 2018
    Publication date: January 3, 2019
    Inventors: Jingye Shanghai, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • FUMIGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180360795
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: January 12, 2018
    Publication date: December 20, 2018
    Inventors: Robert Zahler, James E. Vath
  • FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180237449
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 23, 2018
    Inventors: Robert Zahler, Zhenwei Cai, Zhixing Wu, James E. Vath
  • FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180230137
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 16, 2018
    Inventors: Robert Zahler, James E. Vath
  • Therapeutically active compounds and their methods of use
    Patent number: 10028961
    Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: July 24, 2018
    Assignee: Agios Pharmaceuticals, Inc.
    Inventors: Zenon D. Konteatis, Janeta Popovici-Muller, Jeremy M. Travins, Robert Zahler, Zhenwei Cai, Ding Zhou
  • Fumagillol heterocyclic compounds and methods of making and using same
    Patent number: 10023561
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: July 17, 2018
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Robert Zahler
  • Fumagillol spirocyclic compounds and fused bicyclic compounds and methods of making and using same
    Patent number: 9944613
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: April 17, 2018
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, Zhenwei Cai, Zhixing Wu, James E. Vath
  • FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180079737
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 30, 2017
    Publication date: March 22, 2018
    Inventors: Robert Zahler, Zhenwei Cai, Zhixing Wu, James E. Vath
  • Fumigillol compounds and methods of making and using same
    Patent number: 9895339
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: February 20, 2018
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, James E. Vath
  • Tricyclic sulphonamide compounds and methods of making and using same
    Patent number: 9868717
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: January 16, 2018
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Susan M. Cramp, Hazel J. Dyke, Robert Zahler
  • PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180002307
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: February 15, 2017
    Publication date: January 4, 2018
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Tricyclic compounds and methods of making and using same
    Patent number: 9839623
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 12, 2017
    Assignee: Zafgen, Inc.
    Inventors: David Clark, Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • FUMIGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170342043
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: January 5, 2017
    Publication date: November 30, 2017
    Inventors: Robert Zahler, James E. Vath
  • FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170342058
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: May 16, 2017
    Publication date: November 30, 2017
    Inventors: James E. Vath, Robert Zahler
  • C7-Fluoro Substituted Tetracycline Compounds
    Publication number: 20170275244
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: November 9, 2016
    Publication date: September 28, 2017
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana Katharine Hunt, Roger B. Clark, Robert Zahler
  • Fumagillol heterocyclic compounds and methods of making and using same
    Patent number: 9682965
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 20, 2017
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Robert Zahler
  • Compounds useful as antibiotic tolerance inhibitors
    Patent number: 9643933
    Abstract: The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 9, 2017
    Assignees: The General Hospital Corporation, Institut National de la Recherche Scientifique
    Inventors: Robert Zahler, Ronald Thure Wester, Steven Joseph Brickner
  • THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20170107194
    Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
    Type: Application
    Filed: December 28, 2016
    Publication date: April 20, 2017
    Inventors: Zenon D. Konteatis, Janeta Popovici-Muller, Jeremy M. Travins, Robert Zahler, Zhenwei Cai, Ding Zhou