Patents by Inventor Robert Zahler

Robert Zahler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Partially saturated tricyclic compounds and methods of making and using same
    Patent number: 9617237
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: April 11, 2017
    Assignee: Zafgen, Inc.
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Substituted fused tricyclic compounds, compositions, and medicinal applications thereof
    Patent number: 9593115
    Abstract: The present invention relates to substituted fused tricyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: March 14, 2017
    Inventors: Dinesh Barawkar, Anish Bandyopadhyay, Robert Zahler, Robindro Sarangthem, Yogesh Waman, Rajesh Bonagiri, Dilip Jadhav, Partha Mukhopadhyay
  • COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS
    Publication number: 20170067919
    Abstract: The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.
    Type: Application
    Filed: September 26, 2014
    Publication date: March 9, 2017
    Inventors: David Lawrence Silver, Nam Long Nguyen, Robert Zahler
  • FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170066749
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Inventors: James E. Vath, Robert Zahler
  • Therapeutically active compounds and their methods of use
    Patent number: 9579324
    Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: February 28, 2017
    Assignee: AGIOS PHARMACEUTICALS, INC
    Inventors: Zenon D. Konteatis, Janeta Popovici-Muller, Jeremy M. Travins, Robert Zahler, Zhenwei Cai, Ding Zhou
  • Fumigillol compounds and methods of making and using same
    Patent number: 9573918
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: February 21, 2017
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, James E. Vath
  • Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
    Patent number: 9561230
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2. For example, the invention relates in part to tricyclic sulfonamide compounds represented by Formula I: or pharmaceutically acceptable salts or stereoisomers thereof, wherein A, B, D, RA1, RA2, Y, X and n are as defined herein.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: February 7, 2017
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170001973
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: February 3, 2016
    Publication date: January 5, 2017
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160354338
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: January 7, 2016
    Publication date: December 8, 2016
    Inventors: David Clark, Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • TRICYCLIC PYRAZOLE SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160324865
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: December 14, 2015
    Publication date: November 10, 2016
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Therapeutic compounds and compositions and their use as PKM2 modulators
    Patent number: 9458132
    Abstract: Compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: October 4, 2016
    Assignee: AGIOS PHARMACEUTICALS, INC
    Inventors: Giovanni Cianchetta, Janeta Popovici-Muller, Jeffrey O. Saunders, Robert Zahler
  • Tricyclic sulfone compounds and methods of making and using same
    Patent number: 9440943
    Abstract: The invention provides tricyclic sulfone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: September 13, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160256469
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: October 8, 2015
    Publication date: September 8, 2016
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20160220572
    Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
    Type: Application
    Filed: April 7, 2016
    Publication date: August 4, 2016
    Inventors: Zenon D. Konteatis, Janeta Popovici-Muller, Jeremy M. Travins, Robert Zahler, Zhenwei Cai, Ding Zhou
  • Therapeutic compounds and compositions
    Patent number: 9365545
    Abstract: Compounds of general formula I: and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: June 14, 2016
    Assignee: AGIOS PHARMACEUTICALS, INC
    Inventors: Giovanni Cianchetta, Janeta Popovici-Muller, Robert Zahler, Sheldon Cao, Xiaolei Wang, Zhixiong Ye
  • Tricyclic sulfonamide compounds and methods of making and using same
    Patent number: 9359369
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: June 7, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • TRICYCLIC SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160083362
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 24, 2016
    Inventors: Thomas D. PALLIN, Susan M. CRAMP, Hazel J. DYKE, Robert ZAHLER
  • Partially saturated tricyclic compounds and methods of making and using same
    Patent number: 9290472
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: March 22, 2016
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS
    Publication number: 20160052890
    Abstract: The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.
    Type: Application
    Filed: April 22, 2014
    Publication date: February 25, 2016
    Applicant: The General Hospital Corporation
    Inventors: Robert Zahler, Ronald Thure Wester, Steven Joseph Brickner
  • SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160051531
    Abstract: The invention provides sulphone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: March 24, 2015
    Publication date: February 25, 2016
    Inventors: Hazel J. Dyke, Susan M. Cramp, Thomas D. Pallin, Janusz J. Kulagowski, John G. Montana, Robert Zahler