Patents by Inventor Robert Zahler

Robert Zahler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Partially Saturated Tricyclic Compounds and Methods of Making and Using Same
    Publication number: 20140088078
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: May 7, 2012
    Publication date: March 27, 2014
    Applicant: ZAFGEN, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Tricyclic Pyrazole Sulphonamide Compounds and Methods of Making and Using Same
    Publication number: 20140080822
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: May 7, 2012
    Publication date: March 20, 2014
    Applicant: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Tricyclic Sulfonamide Compounds and Methods of Making and Using Same
    Publication number: 20140073623
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: May 7, 2012
    Publication date: March 13, 2014
    Applicant: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • SUBSTITUTED FUSED TRICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
    Publication number: 20140023614
    Abstract: The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity.
    Type: Application
    Filed: March 21, 2012
    Publication date: January 23, 2014
    Inventors: Dinesh Barawkar, Tanushree Bende, Robert Zahler, Anish Bandyopadhyay, Robindro Singh Sarangthem, Jignesh Doshi, Yogesh Waman, Rushikesh Jadhav, Umesh Prasad Singh
  • AMINO PYRIMIDINE ANTICANCER COMPOUNDS
    Publication number: 20130231306
    Abstract: Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.
    Type: Application
    Filed: January 25, 2013
    Publication date: September 5, 2013
    Applicant: OSI Pharmaceuticals, LLC
    Inventors: Andrew P. CREW, Dan Sherman, Rama Devi Appari, Xin Chen, Ramesh Chilukuri, Hanqing Dong, Caterina Ferraro, Kenneth Foreman, Ramesh C. Gupta, An-Hu Li, Kathryn M. Stolz, Brian Volk, Robert Zahler
  • Sulphonamine Compounds and Methods of Making and Using Same
    Publication number: 20130217759
    Abstract: The invention provides sulphonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: October 12, 2011
    Publication date: August 22, 2013
    Applicant: Zafgen Inc.
    Inventors: Robert Zahler, Hazel Joan Dyke, Thomas David Pallin, Susan Mary Cramp
  • Tricyclic Compounds and Methods of Making and Using Same
    Publication number: 20130123235
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 16, 2013
    Inventors: David Clark, Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20130116248
    Abstract: The present invention relates to substituted imidazo[4,5-c]quinoline derivatives, the compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of formula (I), and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammatory diseases and angiogenesis related disorders.
    Type: Application
    Filed: July 15, 2011
    Publication date: May 9, 2013
    Applicant: PIRAMAL ENTERPRISES LIMITED
    Inventors: Sanjay Kumar, Rajiv Sharma, Robert Zahler, Bichismita Sahu, Veena R. Agarwal, Nishigandha Naik
  • Amino pyrimidine anticancer compounds
    Patent number: 8399433
    Abstract: Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: March 19, 2013
    Assignee: OSI Pharmaceuticals, LLC
    Inventors: Rama Devi Appari, Xin Chen, Ramesh Chilukuri, Andrew P. Crew, Hanqing Dong, Caterina Ferraro, Kenneth Foreman, Ramesh C. Gupta, An-Hu Li, Dan Sherman, Kathryn M. Stolz, Brian Volk, Robert Zahler
  • Sulphone Compounds and Methods of Making and Using Same
    Publication number: 20130053364
    Abstract: The invention provides sulphone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: April 23, 2012
    Publication date: February 28, 2013
    Inventors: Hazel J. Dyke, Susan M. Cramp, Thomas D. Pallin, Janusz J. Kulagowski, John G. Montana, Robert Zahler
  • AMINO PYRIMIDINE ANTICANCER COMPOUNDS
    Publication number: 20110136764
    Abstract: Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.
    Type: Application
    Filed: June 1, 2010
    Publication date: June 9, 2011
    Applicant: OSI Pharmaceuticals, Inc.
    Inventors: Rama Devi APPARI, Xin CHEN, Ramesh Chllukuri, Andrew P. CREW, Hanqing DONG, Caterina FERRARO, Kenneth FOREMAN, Ramesh C. GUPTA, An-Hu LI, Dan SHERMAN, Kathryn M. STOLZ, Brian VOLK, Robert ZAHLER
  • Beta lactam compounds and their use as inhibitors of tryptase
    Patent number: 6335324
    Abstract: Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: January 1, 2002
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Gregory S. Bisacchi, William A. Slusarchyk, Uwe Treuner, James C. Sutton, Robert Zahler, Steven Seiler, David R. Kronenthal, Michael E. Randazzo, Mark D. Schwinden, Zhongmin Xu, Zhongping Shi
  • Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
    Patent number: 5874578
    Abstract: A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl is reacted with the compound of the formulaZ.sub.1 --Xto yield the purine of the formula ##STR2## wherein x is a leaving group, and Z.sub.1 is a protected form of the carbohydrate surrogate Z.
    Type: Grant
    Filed: January 25, 1993
    Date of Patent: February 23, 1999
    Assignee: Bristol-Myers Squibb
    Inventors: Janak Singh, Gregory S. Bisacchi, Jollie D. Godfrey, Jr., Toomas Mitt, Richard H. Mueller, Robert Zahler, Thomas P. Kissick
  • Method of inhibiting protease
    Patent number: 5776933
    Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 7, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Qing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler
  • Aminediol protease inhibitors
    Patent number: 5760036
    Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: June 2, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Oing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler
  • Bis (hydroxymethyl) cyclobutyl purines
    Patent number: 5723609
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts wherein R.sub.1 is ##STR2## wherein R.sub.2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; or trifluoromethyl; R.sub.5 is alkyl; R.sub.6 is hydrogen, alkyl, substituted alkyl, or aryl; and R.sub.7 and R.sub.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: March 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Robert Zahler
  • Purinyl salts useful for preparing guanine containing antiviral agents
    Patent number: 5608064
    Abstract: A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 4, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Janak Singh, Gregory S. Bisacchi, Jollie D. Godfrey, Jr., Toomas Mitt, Richard H. Mueller, Robert Zahler, Thomas P. Kissick
  • Aminediol protease inhibitors
    Patent number: 5559256
    Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: September 24, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Qing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler
  • Process for preparing N-protected amino acid .alpha.-halomethyl ketones and alcohols from N-protected amino acid esters
    Patent number: 5481011
    Abstract: The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: January 2, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ping Chen, Peter T. W. Cheng, Steven H. Spergel, Joel C. Barrish, John K. Thottathil, Robert Zahler, Richard P. Polniaszek, Xuebao Wang
  • Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
    Patent number: 5340816
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: August 23, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, William A. Slusarchyk