Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: According to one aspect, a system is adapted to actively control one or more operating parameters associated with: a wellbore extending in a subterranean formation, and/or wellbore fluid flowing out of the wellbore via a wellhead. The system includes one or more sensors; an electronic controller adapted to receive from the one or more sensors measurement data; and a valve through which the wellbore fluid is adapted to flow. The valve is adapted to be in communication with the electronic controller. The active control of the at least one of the one or more operating parameters is adapted to facilitate: maintenance of the integrity of the wellbore, and/or enhancement of oil and/or gas production out of the wellbore. In one embodiment, the wellbore fluid flow is frac flow-back. In another aspect, a system is adapted to monitor vent gas separated from wellbore fluid flowing out a wellhead.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are. disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: The present invention relates to the field of pulmonary, cardiac and inflammatory disorders. More specifically, the present invention provides methods and compositions for treating disorders associated with Resistin. In a specific embodiment, the present invention provides an antibody that binds human Resistin.

Abstract: An MRI pulse sequence is disclosed. The pulse sequence involves a plurality of slice selective pulses which each individually have a desired rotation that is less than or equal to the total desired rotation. The slice selective pulses each cause a rotation about respective axes, which may be different to each other. Optionally phase correction (re-phasing) gradients can also be included in the pulse sequence.

Abstract: The present invention relates to compounds which are of use in the field of agriculture as fungicides.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: An MRI pulse sequence is disclosed. The pulse sequence involves a plurality of slice selective pulses which each individually have a desired rotation that is less than or equal to the total desired rotation. The slice selective pulses each cause a rotation about respective axes, which may be different to each other. Optionally phase correction (re-phasing) gradients can also be included in the pulse sequence.

Abstract: The present disclosure relates to an automated process and associated computerized system and method implemented over an automated system for generating Job Reports for different job offers of employers, where the new process and associated system allows an employer to customize template Job Reports with one or more of different fields using a cloud-based Application Programming Interface (API). The system further includes a fully integrated system to interface with an employer's Applicant Tracking System (ATS) designed to help employers track multiple new features associated with the customized Job Reports generated and make alterations that do not require production time.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are. disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: A computing system configured to execute instructions for a first graphical processing unit (GPU) on a second GPU is provided. The computing system may include the second GPU and a processor. The processor may be configured to receive second GPU state data that indicates one or more global properties of the second GPU. The processor may be further configured to receive one or more binary instructions for texture operation configured to be executed on the first GPU. Based on the second GPU state data, the processor may be further configured to apply a texture value patch to the one or more binary instructions. Applying the texture value patch may translate the one or more binary instructions into one or more translated binary instructions configured to be executed on the second GPU.

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

Abstract: A prosthetic glenoid component (10) comprising a concave external bearing surface (12), a glenoid-contacting surface (14) opposite to the bearing surface, and a plurality of fixation elements (16) protruding from said glenoid-contacting surface (14) oppositely to said bearing surface (12) for location into a peripheral portion (104b) of a glenoid cavity (104) to secure the component to the scapula (102), wherein a central portion (15) of the glenoid-contacting surface (14) is free of fixation elements so as to preserve the integrity of the glenoid vault.

Abstract: The present invention relates to 2-thiobenzimidazoles of formula (I) which are of use as fungicides.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: An MRI pulse sequence is disclosed. The pulse sequence involves a plurality of slice selective pulses (51,55) which each individually have a desired rotation that is less than or equal to the total desired rotation. The slice selective pulses each cause a rotation about respective axes, which may be different to each other. Optionally phase correction (re-phasing) gradients (53, 56) can also be included in the pulse sequence.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.