Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The disclosure concerns systems and methods for extracting data from documents. A computer receives a message from a sender. The message has the electronic document and an electronic address of the sender. Based on the address of the sender the computer selects a map that comprises location data of data fields and determines values of the data fields by extracting data from the electronic document using the location data of the selected map. Since the computer selects the map based on the address of the sender the computer does not need to rely on the content of the electronic document to select the correct map to use, which makes the selection less prone to errors and the method can be used with existing email systems.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: According to one aspect, a system is adapted to actively control one or more operating parameters associated with: a wellbore extending in a subterranean formation, and/or wellbore fluid flowing out of the wellbore via a wellhead. The system includes one or more sensors; an electronic controller adapted to receive from the one or more sensors measurement data; and a valve through which the wellbore fluid is adapted to flow. The valve is adapted to be in communication with the electronic controller. The active control of the at least one of the one or more operating parameters is adapted to facilitate: maintenance of the integrity of the wellbore, and/or enhancement of oil and/or gas production out of the wellbore. In one embodiment, the wellbore fluid flow is frac flow-back. In another aspect, a system is adapted to monitor vent gas separated from wellbore fluid flowing out a wellhead.

Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.

Abstract: According to one aspect, a system is adapted to actively control one or more operating parameters associated with: a wellbore extending in a subterranean formation, and/or wellbore fluid flowing out of the wellbore via a wellhead. The system includes one or more sensors; an electronic controller adapted to receive from the one or more sensors measurement data; and a valve through which the wellbore fluid is adapted to flow. The valve is adapted to be in communication with the electronic controller. The active control of the at least one of the one or more operating parameters is adapted to facilitate: maintenance of the integrity of the wellbore, and/or enhancement of oil and/or gas production out of the wellbore. In one embodiment, the wellbore fluid flow is frac flow-back. In another aspect, a system is adapted to monitor vent gas separated from wellbore fluid flowing out a wellhead.

Abstract: We found that FIZZ1/RELM? is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELM? was located in the pulmonary vasculature, bronchial epithelial cells, and type II pneumocytes. Recombinant FIZZ1/RELM? protein stimulates rat pulmonary microvascular smooth muscle cell (RPSM) proliferation dose-dependently. Therefore, we renamed this gene as hypoxia-induced mitogenic factor (HIMF). HIMF strongly activated Akt phosphorylation. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 inhibits HIMF-activated Akt phosphorylation. It also inhibits HIMF-stimulated RPSM proliferation. Thus, the PI3K/Akt pathway, at least in part, mediates the proliferative effect of HIMF. HIMF also has angiogenic and vasoconstrictive activity. Notably, HIMF increases pulmonary arterial pressure and vascular resistance more potently than either endothelin-1 or angiotensin II.

Abstract: Examples described herein improve the quality of the video frames that are rendered and displayed. A system is configured to generate render targets based on instructions received from a source of video content. The system is configured to create and/or access a selection parameter and use the selection parameter to identify one or more of the render targets to be scaled. Once identified, the system scales a native size (e.g., a native resolution) of an identified render target to a larger size (e.g., based on a predetermined scaling factor), thereby generating a higher density render target. The higher density render target, or a corresponding higher density render target texture (RTT), can be used in a rendering pipeline to produce a video frame in a higher output resolution (e.g., 4k resolution) compared to the output resolution specified in the instructions (e.g., 720p resolution).

Abstract: The present invention relates to a surgical apparatus including a magazine which is arranged to receive a plurality of medical interventions particularly for use in surgery.

Abstract: A computing device for just-in-time cross-compiling compiled binaries of application programs that utilize graphics processing unit (GPU) executed programs configured to be executed on a first GPU having a first application binary interface (ABI) including a second GPU having a second ABI different from the first ABI of the first GPU, and a processor configured to execute an application program that utilizes a plurality of GPU-executed programs configured to be executed for the first ABI of the first GPU, execute a run-time executable cross-compiler configured to, while the application program is being executed, emulate the first ABI using hardware resources of the second GPU by translating between the first ABI and the second ABI, and execute the plurality of GPU-executed programs on the second GPU with the emulated first ABI, and pass output of the plurality of GPU-executed programs for the emulated first ABI through the second ABI.

Abstract: Examples described herein improve the quality of the video frames that are rendered and displayed. A system is configured to generate render targets based on instructions received from a source of video content. The system is configured to create and/or access a selection parameter and use the selection parameter to identify one or more of the render targets to be scaled. Once identified, the system scales a native size (e.g., a native resolution) of an identified render target to a larger size (e.g., based on a predetermined scaling factor), thereby generating a higher density render target. The higher density render target, or a corresponding higher density render target texture (RTT), can be used in a rendering pipeline to produce a video frame in a higher output resolution (e.g., 4k resolution) compared to the output resolution specified in the instructions (e.g., 720p resolution).

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A braking system for an autonomous vehicle includes a brake device that is configured to brake a vehicle wheel. A first control system includes a first pump fluidly connected to the brake device via a hydraulic circuit. A second control system includes a second pump fluidly connected to the brake device via the hydraulic circuit. The second pump is fluidly connected in parallel with the first pump. A controller is in communication with the first and second control systems. The controller is configured to detect a fault in the first control system. The controller is configured to command the second pump to pressurize the hydraulic circuit in response to the failure.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A braking system for an autonomous vehicle includes a brake device that is configured to brake a vehicle wheel. A first control system includes a first pump fluidly connected to the brake device via a hydraulic circuit. A second control system includes a second pump fluidly connected to the brake device via the hydraulic circuit. The second pump is fluidly connected in parallel with the first pump. A controller is in communication with the first and second control systems. The controller is configured to detect a fault in the first control system. The controller is configured to command the second pump to pressurize the hydraulic circuit in response to the failure.

Abstract: A computing device for just-in-time cross-compiling compiled binaries of application programs that utilize graphics processing unit (GPU) executed programs configured to be executed on a first GPU having a first application binary interface (ABI) including a second GPU having a second ABI different from the first ABI of the first GPU, and a processor configured to execute an application program that utilizes a plurality of GPU-executed programs configured to be executed for the first ABI of the first GPU, execute a run-time executable cross-compiler configured to, while the application program is being executed, emulate the first ABI using hardware resources of the second GPU by translating between the first ABI and the second ABI, and execute the plurality of GPU-executed programs on the second GPU with the emulated first ABI, and pass output of the plurality of GPU-executed programs for the emulated first ABI through the second ABI.

Abstract: A computing system configured to execute instructions for a first graphical processing unit (GPU) on a second GPU is provided. The computing system may include the second GPU and a processor. The processor may be configured to receive second GPU state data that indicates one or more global properties of the second GPU. The processor may be further configured to receive one or more binary instructions for texture operation configured to be executed on the first GPU. Based on the second GPU state data, the processor may be further configured to apply a texture value patch to the one or more binary instructions. Applying the texture value patch may translate the one or more binary instructions into one or more translated binary instructions configured to be executed on the second GPU.

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.