Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention relates to a surgical apparatus including a magazine which is arranged to receive a plurality of medical interventions particularly for use in surgery.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.

Abstract: The present invention relates to the field of pulmonary, cardiac and inflammatory disorders. More specifically, the present invention provides methods and compositions for treating disorders associated with Resistin. In a specific embodiment, the present invention provides an antibody that binds human Resistin.

Abstract: The present disclosure relates to a multi-step method for processing peroxygen solutions for reuse or disposal. The method uses an enzyme and a reducing agent.

Abstract: A braking system for an autonomous vehicle includes a brake device that is configured to brake a vehicle wheel. A first control system includes a first pump fluidly connected to the brake device via a hydraulic circuit. A second control system includes a second pump fluidly connected to the brake device via the hydraulic circuit. The second pump is fluidly connected in parallel with the first pump. A controller is in communication with the first and second control systems. The controller is configured to detect a fault in the first control system. The controller is configured to command the second pump to pressurize the hydraulic circuit in response to the failure.

Abstract: A core for an electric machine includes a core component having a plurality of core teeth defining a plurality of core slots between adjacent core teeth of the plurality of core teeth. The plurality of core slots are receptive of one or more windings. A coolant flowpath through the core component is formed through at least one core tooth. The at least one core tooth has one or more coolant tube banks and one or more mixing chambers arranged in an alternating pattern along the at least one core tooth.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are. disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.

Abstract: Hypoxia induced mitogenic factor (HIMF) is a member of the “found in inflammatory zone” (FIZZ)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. We identified Bruton's tyrosine kinase (BTK) as a functional HIMF binding partner through GST-HIMF pull-downs and mass spectrometry. Using primary cultured HIMF-stimulated murine bone marrow cells, we demonstrated that BTK was recruited to the leading edge of the cells. We also demonstrated that BTK and the closely related tyrosine kinase Fyn, colocalized at the growth cone process in these cells. HIMF stimulation induced BTK autophosphorylation, which peaked at 2.5 minutes. A transwell migration assay showed that treatment with recombinant murine HIMF induced migration of primary cultured bone marrow cells, which was completely blocked by the BTK inhibitor, LFM-A13.

Abstract: The present disclosure relates to an automated process and associated computerized system and method implemented over an automated system for generating Job Reports for different job offers of employers, where the new process and associated system allows an employer to customize template Job Reports with one or more of different fields using a cloud-based Application Programming Interface (API). The system further includes a fully integrated system to interface with an employer's Applicant Tracking System (ATS) designed to help employers track multiple new features associated with the customized Job Reports generated and make alterations that do not require production time.

Abstract: A modular gas exhaust assembly for a circuit breaker having a plurality of arc chutes, each having an associated expulsion location. The modular gas exhaust assembly includes a plurality of modular exhaust casings. Also included is a plurality of gas channels, each channel defined by one of the plurality of modular exhaust casings, the plurality of modular exhaust casings each configured to be removably coupled to at least one of the arc chute expulsion locations of the plurality of arc chutes, wherein the number of the plurality of gas channels is equal to the number of a plurality of poles of the circuit breaker, each gas channel aligned with a respective pole and configured to separately exhaust arc gases from the respective pole of the circuit breaker.

Abstract: The present invention is a device for aiming a dental x-ray beam to be centered parallel to the area of contact between two adjacent teeth so that the resultant bite wing radiographic image is one that shows at least those two teeth as distinct and not superimposed images. The device, comprising a marginal ridge angulation locator that indexes into the substantially v-shaped groove on the biting surfaces between two adjacent teeth, locates and indicates an aiming vector centered over and parallel to the area of contact between those two teeth for the purpose of aiming an x-ray beam then exposing the radiographic image desired.

Abstract: The present disclosure relates to an automated process and associated computerized system for improving the recruitment process of qualified candidates for opened positions of different job postings, the process and system includes a platform for transforming information into a video posting displaying human and written video highlights based on the information, and more particularly to an online platform which includes multiple different functions, which includes uploading a text job opening and receiving a encoded video to imbed in internet sites where job seekers can access the posting, offering a more cost efficient alternative for a semi-manual job reports generation, and the automated process of generating a post-response candidate expectation video and support information.

Abstract: A composition for the marking of assets comprising: a base material; and two or more encoding compounds wherein each of the two or more encoding compounds are provided at measurable concentrations.

Abstract: The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.