Abstract: Disclosed herein is method and system for determining quality of semen sample. Trajectories of objects, identified in each of plurality of image frames of semen sample, are generated by tracking movement of the objects across image frames, and compensating a drift velocity of the semen sample. Further, generated trajectories are classified into sperm and non-sperm trajectories. Finally, total concentration estimate and total motility estimate of the semen sample are computed to generate a semen quality index, which indicates quality of the semen sample. In an embodiment, the method of present disclosure uses a multi-level Convolutional Neural Network (CNN) analysis technique for effectively classifying the object trajectories into sperm and non-sperm objects. Also, since the present method includes estimating and compensating drift velocity in the semen sample, it enhances overall accuracy of motility estimation and semen quality analysis.

Abstract: The invention provides a process for producing methanol, which process comprises contacting H2 and CO2 with a solid catalyst, at a temperature of from 200° C. to 300° C. and at a reactant pressure of from 150 bar to 500 bar, which reactant pressure is the sum of the partial pressures of the H2 and the CO2, wherein: the molar ratio of the H2 to the CO2 is x:1.0, wherein x is from 2.5 to 3.5; and the catalyst comprises: (i) a copper component which is Cu, CuO or Cu2O, or a mixture of two or three thereof, and (ii) ZnO, wherein the catalyst has a specific copper surface area of at least 10 m2/g-catalyst.

Abstract: Disclosed herein is a system and a method for improving the energy management of HVAC equipment. The system comprising: a plurality of sensors distributed in a building for sensing a set of parameters including environmental information, thermal zone information, energy consumption information, operational parameter information and field information from the building; a network for connecting the plurality of sensors; a server includes a hybrid platform with physics based simulation model and machine learning model for processing and controlling the parameters of the HVAC equipment.

Abstract: A system and computer implemented method for cataloging database metadata using a probabilistic signature matching process are provided. The method includes receiving an input name to be matched to keys in a data corpus; dividing the received input name into a plurality of text segments; identifying a set of matching keys by matching each of the plurality text segments against keys in the data corpus; analyzing the set of matching keys to construct a tag; and cataloging the metadata with the matching key as the construct tag.

Abstract: A mold includes a main body and a separable feature. One or more first weakened regions join the separable feature to the main body. The one or more first weakened regions are breakable to enable the main body to be removed from a shell independently of the separable feature after the shell is formed over the mold. The main body includes a first section and a second section that are at least partially separable at one or more second weakened regions to enable the first section to be removed from the shell independently of the second section after the shell is formed over the mold.

Abstract: Embodiments of present disclosure discloses system and method for acquisition of optimal images of object in multi-layer sample. Initially, images for FOV of multi-layer sample comprising objects are retrieved. Each of images are captured by varying focal depth of image capturing unit associated with system. Further, objects associated with multi-layer sample in FOV are identified. For identification, cumulative foreground mask of FOV is obtained based on adaptive thresholding performed on foreground image of FOV. Based on contour detection performed on cumulative foreground mask of FOV, object masks, corresponding to objects, is obtained for identifying objects. Further, sharpness of each of images associated with each of object masks is computed. Based on sharpness, optimal images from images for each of objects is selected for acquisition of optimal images of objects in multi-layer sample.

Abstract: Digital content design system techniques are described using baseline units to control arrangement and sizing of digital content. In one example, a digital content design system receives a user input specifying a number of baselines to be included within an available display area of a page. Baselines are used to align digital content to control arrangement of the digital content within the page, e.g., text. From this, the digital content design system then calculates a baseline unit from a distance used to space adjacent baselines of the number of baselines from each other. This baseline unit is then leveraged by the system as a fundamental unit of measure to control arrangement and/or sizing of digital content in relation to each other.

Abstract: A device is disclosed, which may include a color-filter layer and a thin-film transistor (TFT) layer. The TFT layer may have an alignment layer. The device may have spacers, between the color-filter layer and the TFT layer, that form space between the color-filter layer and the TFT layer for liquid crystals. The device may include a scratch-resistant coating on the alignment layer of the TFT layer.

Abstract: An example of an apparatus to detect a target component in a test sample is provided. The apparatus includes a sample pad to receive the test sample. The apparatus further includes a conjugate pad in communication with the sample pad to receive the test sample. The test sample is to interact with a first luminescent particle having a protein and a plurality of primary antibodies to form a conjugated sample. A primary antibody binds with the target component. In addition, the apparatus includes an enhancement pad in communication with the conjugate pad to receive the conjugated sample. The conjugated sample is to interact with a second luminescent particle having a chemical molecule which links with the protein to form an enhanced sample. Furthermore, the apparatus includes a membrane in communication with the enhancement pad to receive the enhanced sample. The membrane includes a test region treated with the target component.

Abstract: The present invention relates to a tablet composition comprising ibrutinib and one or more pharmaceutically acceptable excipients, characterized in that: ibrutinib is form C, having characteristic peaks in the X-ray powder diffraction pattern at the following 2 theta (±0.2) angles: 6.9°, 18.2°, 19.2°, 19.6° and 23.0°, measured using a Cu K? radiation, and the composition is free of surfactant, and the composition exhibits a dissolution rate of at least 65% in 20 minutes when tested in 900 ml 0.01 N hydrochloric acid pH 2.0 (+1% Tween 20) at 37° C., 75 rpm and/or in 900 ml phosphate buffer pH 6.8 (+3% Tween 20) at 37° C., 75 rpm in a USP apparatus II. The invention further relates to the use of said composition as a medicament, particularly in the treatment of chronic lymphocytic leukaemia (CLL), mantle cell lymphoma (MCL) and Waldenström's macroglobulinaemia (WM).

Abstract: A fixation device includes a first anchor portion configured to join to a first bone portion, a second anchor portion configured to join to a second bone portion, and an intermediate component that extends between the first anchor portion and the second anchor portion. The intermediate component is configured to expand, contract, and angulate enabling constrained movement of the second bone portion with respect to the first bone portion. The second anchor portion has a larger configuration relative to the first anchor portion, thereby preventing the second bone portion from depressing below the first bone portion.

Abstract: A method and apparatus for distributed services and data in a machine-to-machine (M2M) communication network are disclosed. A network server, an M2M gateway, and M2M devices include an M2M service capability layer for supporting M2M service capabilities, respectively. Reference points may be defined for interactions between network service capability layers, between gateway service capability layers, between a gateway service capability layer and a device service capability layer of an M2M device, between M2M device applications, and/or between a network, gateway, or device service capability layer and an M2M application. The network server may be split into a control server and a data server at a service capability layer to provide service capabilities for control functions and service capabilities for data functions, respectively. The data server may be configured to interact with another data server to push or pull data or resources either directly or indirectly via the control server.

Abstract: A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo [d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.

Abstract: In some examples, embedded designer implementation may include, upon receiving an indication of actuation of a second designer launch element that is included in a first designer, launching a second designer inline from the first designer. Further, embedded designer implementation may include, upon receiving an indication of actuation of a first designer return element that is included in the second designer, returning to the first designer inline from the second designer. The first designer and the second designer may include a configurable component. Further, embedded designer implementation may include utilizing a common portion of the memory for the configurable component.

Abstract: Systems, methods, and computer-readable media are disclosed for optimization of ad request fulfillment for mobile device applications. In one embodiment, a system may receive an ad request from a mobile device, and determine a first price point associated with a publisher of the ad request. The system may send a bid request to ad servers, receive a first bid with a first bid amount, and may determine that the first bid amount is a highest bid amount. The system may determine that the first price point is less than the first bid amount, and may send the first bid amount and the first price point to the mobile device, where the mobile device is configured to send the first bid amount and the first price point to a publisher ad server, and the publisher ad server is configured to determine that the first bid amount is a winning bid amount.

Abstract: The present invention relates to a tablet composition comprising ibrutinib and one or more pharmaceutically acceptable excipients, characterized in that: ibrutinib is form C, having characteristic peaks in the X-ray powder diffraction pattern at the following 2 theta (±0.2) angles: 6.9°, 18.2°, 19.2°, 19.6° and 23.0°, measured using a Cu K? radiation, and the composition is free of surfactant, and the composition exhibits a dissolution rate of at least 65% in 20 minutes when tested in 900 ml 0.01 N hydrochloric acid pH 2.0 (+1% Tween 20) at 37° C., 75 rpm and/or in 900 ml phosphate buffer pH 6.8 (+3% Tween 20) at 37° C., 75 rpm in a USP apparatus II. The invention further relates to the use of said composition as a medicament, particularly in the treatment of chronic lymphocytic leukaemia (CLL), mantle cell lymphoma (MCL) and Waldenström's macroglobulinaemia (WM).

Abstract: In one embodiment, an apparatus includes an optical module comprising a first end for insertion into a network device and a second end extending from the network device when the optical module is inserted into the network device, and a thermal protective layer extending over a portion of the second end of the optical module, the thermal protective layer preventing direct contact with an external surface of the optical module during removal of the optical module from the network device. The thermal protective layer exposes a portion of the external surface of the second end of the optical module to allow heat to be released from the external surface of the optical module.

Abstract: An example method can include choosing a pattern or patterns of network traffic. This pattern can be representative of a certain type of traffic such as an attack. The pattern can be associated with various components of a network and can describe expected behavior of these various components. A system performing this method can then choose a nodes or nodes to generate traffic according to the pattern and send an instruction accordingly. After this synthetic traffic is generated, the system can compare the behavior of the components with the expected behavior. An alert can then be created to notify an administrator or otherwise remedy any problems.

Abstract: Techniques are described for performing a read scan process on a non-volatile memory system in order to determine memory blocks that may have a high bit error rate, where if such blocks are found they can be refreshed. Rather than work through the blocks of a memory system sequentially based on the physical block addresses, the memory system maintains a measure of data quality, such as an estimated or average bit error rate, for multi-block groups. For example, the groups can correspond to regions of memory die in the system. The groups are ranked by their data quality, with the groups being scanned in order of the data quality. The blocks within a group can also be ranked, based on factors such as the program/erase count.

Abstract: A computer-implemented system and method for providing alerts in an online learning environment is provided. An electronic gradebook is maintained for a teacher of an online learning environment and includes education related data for each student of the teacher. An event in the online learning environment is identified based on receipt of further education related data for one of the students of the teacher for entry into the electronic gradebook. Automatically upon receipt into the electronic gradebook, an alert is generated for the event by identifying a type of the further education related data received and selecting a template for the alert based on the type of the further education related data. The template is filled with the further education related data and recipients of the alert that are associated with the student are identified. The alert is delivered to the identified recipients.