Abstract: The present invention relates to compounds which selectively inhibit CYP11B1. Preferably, the compounds of the present invention do not substantially inhibit CYP11B2. Moreover, the compounds of the present invention do not substantially inhibit CYP17 and/or CYP19, either. Amongst other applications of the compounds of the present invention, they can be used for the treatment of Cushing's syndrome or metabolic disease.

Abstract: The invention relates to selective, non-steroidal 17beta-hydroxysteroid dehydrogenase type 2 (l7beta-HSD2) inhibitors of formula (I), their production and use, notably for the treatment and prophylaxis of sex steroid deficient diseases like osteoporosis in men and women.

Abstract: This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

Abstract: The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases. The invention further relates to suitable inhibitors and to a method for the production thereof.

Abstract: A functional PET imaging method is disclosed for differentiation between bilateral hyperplasia and unilateral adenoma comprising (1) introducing a radioactively labelled CYP11 B2 (aldosterone synthase) inhibitor which binds selectively to CYP11 B2 (aldosterone synthase) relative to CYP11 B1 (11?-hydroxylase) into a mammal with adrenal glands and (2) conducting positron emission tomography (PET) in the region of the adrenal glands to obtain a functional PET image of the adrenal glands. Also disclosed are radioactive tracer compounds suitable for use in this method, precursors for making the same, and a process for making the radioactive tracer compounds capable of being conducted as a rapid one-pot reaction.

Abstract: A display and operating system of a motor vehicle includes an instrument cluster that is formed by a plurality of display devices and has an outer left-hand display device and an outer right hand display device. A steering wheel of the system includes an outer left-hand operating device configured exclusively for driver interaction with the outer left-hand display device of the instrument cluster and an outer right-hand operating device configured exclusively for driver interaction with the outer right-hand display device of the instrument cluster. Further devices, including at least one of a display device or an operating device, are disposed laterally adjacent to the instrument cluster.

Abstract: A display device for a hybrid motor vehicle is configured to display a map that corresponds to a current vehicle position as controlled by a navigation device and to show at least two regions on the map. The regions include a first region that is reachable by the motor vehicle using available electrical energy when driving under purely electromotive power, and a second region that is reachable by the motor vehicle using an available quantity of fuel when driving under at least one of purely internal combustion engine power or combined electromotive power and internal combustion engine power.

Abstract: A display device of a motor vehicle, on which a map corresponding to a current vehicle position can be displayed in a display mode under the control of a navigation device, wherein a racetrack on which the motor vehicle is operated can be displayed on the display device in a further display mode.

Abstract: A device for in situ milling of joint surfaces, including a milling device (20, 24) and a joint clamping device (10). The joint clamp device (10) is designed to be inserted between two joint components forming a joint, particularly bones (1, 3), and for pushing the joint components (1, 3) apart with a predetermined or adjustable tension, wherein the joint clamping device (10) includes a recess (11) in which the milling device (20, 24) can be inserted, wherein the milling device (20, 24) includes a face milling cutter (21).

Abstract: The invention relates to 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) inhibitors, the preparation thereof and the use thereof for the treatment and prophylaxis of hormone-related, especially estrogen-related or androgen-related, diseases.

Abstract: The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases. The invention further relates to suitable inhibitors and to a method for the production thereof.

Abstract: Apparatus for minimum invasive fasciectomy, characterized by a tubular fixation element, including two detachably interconnected semitubular shells with in each case a wedge-shaped recess formed at a proximal end and at a distal end, a deflecting bar, whose length essentially corresponds to the portion between the recesses, and lifting wedges with in each case receptacles located at the lower portion thereof for the detachable connection of the lifting wedges to the deflecting bar, wherein the titling wedges can be introduced into the wedge-shaped recesses, accompanied by a sliding apart of the detachably interconnected semitubular shells.

Abstract: The invention relates to compounds for selectively inhibiting human corticosteroid syntheses CYP11B1 and CYP11B2, to the production thereof and to their use for treating hypercortisolism and diabetes mellitus or insufficiency of the heart and myocardial fibrosis.

Abstract: A method and an apparatus allow for the menu-controlled selection of menu items which have associated files containing audio and/or video data. A first menu level with a plurality of first menu items and a second menu level with a plurality of second menu items, which are dependent on a first selection of one of the first menu items, are shown successively on a display device. After selection of one of the second menu items, the first menu level with the plurality of first menu items is shown again. This allows the plurality of first menu items to be able to be selected randomly after the first menu level has been shown again. The user can therefore select any of the menu items on the first menu level as desired. He is not restricted in his selection in any way.

Abstract: The invention involves a device for putting an anti-mite agent into a mattress. In order to ensure that a mattress is not just sprayed on the surface with an anti-mite agent, it is proposed to provide a corresponding device with structural components which have at least one hollow needle, with which an outer covering of a mattress is punctured so that a mattress can be vaccinated using these devices with anti-mite agent.

Abstract: Connection device and process for connecting a hydrocyclone to a distribution and collection device, in which distribution and collection device includes connection openings for addition or removal of liquid during operation of the hydrocyclone. Connection device includes a pipe piece having an insertion side structured and arranged to be insertable through one of the connection openings into distribution and collection device. The insertion side includes a circumferential groove and a radial protrusion positioned adjacent circumferential groove, and radial protrusion has an outer diameter smaller than an inner diameter of the one connection opening and is structured to remain within distribution and collection device.

Abstract: Hydrocyclone device including at least one hydrocyclone having at least one feeding connector, at least one accepted stock connector, and at least one rejected stock connector. The device also includes at least one distribution and collection device arranged for feeding fluids into and removing fluids from the at least one hydrocyclone, and at least one flange coupled to at least one of the at least one feeding connnector, the at least one accepted stock connector, and the at least one rejected stock connector, which is removably couplable to the at least one distribution and collection device.

Abstract: Hydrocyclone and process for removing foreign substances from a liquid to be cleaned. The hydrocyclone includes at least one inlet for the liquid to be cleaned, at least one accepted stock outlet for the cleaned liquid, and at least one reject opening for foreign substances removed from the liquid to be cleaned. The at least one reject opening includes at least one stoppage-hazard zone, and a color layer is coupled to an exterior wall of the hydrocyclone. The color layer changes appearance in accordance with different temperatures. The process includes introducing the liquid to be cleaned into a hydrocyclone through at least one inlet, discharging cleaned liquid from the hydrocyclone through at least one accepted stock outlet, and discharging the foreign substances from the hydrocyclone through at least one reject opening.

Abstract: Connection device and process for connecting a hydrocyclone to a distribution and collection device, in which distribution and collection device includes connection openings for addition or removal of liquid during operation of the hydrocyclone. Connection device includes a pipe piece having an insertion side structured and arranged to be insertable through one of the connection openings into distribution and collection devioce. The insertion side includes a circumferential groove and a radial protrusion positioned adjacent circumferential groove, and radial protrusion has an outer diameter smaller than an inner diameter of the one connection opening and is structured to remain within distribution and collection device.

Abstract: Hydrocyclone device including at least one hydrocyclone having at least one feeding connector, at least one accepted stock connector, and at least one rejected stock connector. The device also includes at least one distribution and collection device arranged for feeding fluids into and removing fluids from the at least one hydrocyclone, and at least one flange coupled to at least one of the at least one feeding connnector, the at least one accepted stock connector, and the at least one rejected stock connector, which is removably couplable to the at least one distribution and collection device.