Patents by Inventor Roman Sakowicz

Roman Sakowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput sarcomeric assay
    Publication number: 20030203835
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: April 15, 2003
    Publication date: October 30, 2003
    Applicant: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Motor proteins and methods for their use
    Patent number: 6638754
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: October 28, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Roman Sakowicz
  • Antifungal assay
    Patent number: 6627408
    Abstract: The present invention provides high throughput screening Systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: September 30, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
  • Methods of screening for modulators of cell proliferation
    Patent number: 6617115
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: September 9, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Methods for screening and therapeutic applications of kinesin modulators
    Patent number: 6613540
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: September 2, 2003
    Assignee: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • Kinesin motor modulators derived from the marine sponge adocia
    Publication number: 20030127621
    Abstract: This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vitro and in vivo applications.
    Type: Application
    Filed: November 27, 2002
    Publication date: July 10, 2003
    Inventors: Lawrence S.B. Goldstein, David John Faulkner, Roman Sakowicz, Michael S. Berdelis, Christine L. Blackburn, Cordula Hopmann
  • Novel motor protein of P. falciparum and methods for its use
    Publication number: 20030104496
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of PfKinI-1, antibodies to PfKinI-1, methods of screening for PfKinI-1 modulators using biologically active PfKinI-1, and kits for screening for PfKinI-1 modulators.
    Type: Application
    Filed: November 30, 2001
    Publication date: June 5, 2003
    Applicant: Cytokinetics, Inc.
    Inventors: Roman Sakowicz, Christophe Beraud, Jun Guo, Richard Freedman
  • Sarcomere protein composition
    Patent number: 6573061
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 3, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Human kinesins and methods of producing and purifying human kinesins
    Patent number: 6544766
    Abstract: Described herein are methods of producing kinesins. In a preferred embodiment, the kinesins are produced from a prokaryote, most preferably, a bacterial cell. Bacterial expression offers several advantages over systems previously utilized, such as, for example, Bacculovirus. The yield of protein is higher, the cost of the expression setup is lower, and creation of alternative expression vectors is easier. The concern of copurifying a contaminating activity from the expression host is also eliminated since bacteria, in contrast to the bacculovirus expression system, do not have kinesin like proteins. Also described herein are purified kinesins, preferably unglycosylated and methods of use.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: April 8, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Cara Ohashi, Roman Sakowicz, Eugeni Vaisberg, Ken Wood, Ming Yu
  • Human kinesins and methods of producing and purifying human kinesins
    Publication number: 20030044900
    Abstract: Described herein are methods of producing kinesins. In a preferred embodiment, the kinesins are produced from a prokaryote, most preferably, a bacterial cell. Bacterial expression offers several advantages over systems previously utilized, such as, for example, Bacculovirus. The yield of protein is higher, the cost of the expression setup is lower, and creation of alternative expression vectors is easier. The concern of copurifying a contaminating activity from the expression host is also eliminated since bacteria, in contrast to the bacculovirus expresion system, do not have kinesin like proteins. Also described herein are purified kinesins, preferably unglycosylated and methods of use.
    Type: Application
    Filed: October 19, 2001
    Publication date: March 6, 2003
    Applicant: Cytokinetics
    Inventors: Christophe Beraud, Cara Ohashi, Roman Sakowicz, Eugeni Vaisberg, Ken Wood, Ming Yu
  • Human smooth muscle myosin heavy chain
    Publication number: 20030032018
    Abstract: The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
    Type: Application
    Filed: August 10, 2001
    Publication date: February 13, 2003
    Applicant: Cytokinetics, Inc.
    Inventors: Fady Malik, Christophe Beraud, Richard Freedman, Andrew Craven, Roman Sakowicz, James Hartman
  • High throughput sarcomeric assay
    Patent number: 6509167
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 21, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • High throughput sarcomeric assay
    Patent number: 6495337
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: December 17, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Kinesin motor modulators derived from the marine sponge Adocia
    Patent number: 6489134
    Abstract: This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vitro and in vivo applications.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: December 3, 2002
    Assignee: The Regents of the University of California
    Inventors: Lawrence S.B. Goldstein, David John Faulkner, Roman Sakowicz, Michael S. Berdelis, Christine L. Blackburn, Cordula Hopmann
  • Antifungal assay
    Patent number: 6468760
    Abstract: The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 22, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
  • Methods of identifying modulators of kinesin motor proteins
    Patent number: 6440684
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 27, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Jeffrey T. Finer, Roman Sakowicz, Kenneth W. Wood
  • Methods for screening and therapeutic applications of kinesin modulators
    Patent number: 6440686
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: August 27, 2002
    Assignee: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • Nucleic acids encoding KSP, a kinesin motor protein
    Patent number: 6437115
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 20, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Novel motor proteins and methods for their use
    Publication number: 20020110883
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.
    Type: Application
    Filed: June 15, 2001
    Publication date: August 15, 2002
    Applicant: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Andrew Craven, Ming Yu, Roman Sakowicz, Umesh A. Patel, Katherine A. Davies
  • Human kinesin protein KSP
    Patent number: 6414121
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: July 2, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz