Abstract: A method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model uses a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed.

Abstract: A catheter (700, 800, 1206) comprising: a shaft with distal (808, 906, 1004, 208) and proximal ends (1006),wherein the distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210); and a connector (1012) at the proximal end for supplying the at least one array of capacitive micromachined ultrasound transducers with electrical power and for controlling the adjustable focus.

Abstract: An image projection system having a laser projector that projects two differently polarized images on a display region is disclosed. The laser projector enables viewing the two differently polarized images as a three-dimensional image. The image projection system includes a planar lightwave circuit-based beam combiner that enables multiple colors of laser light having different polarization modes to be combined in a single output beam that is scanned over the display region at video rates to produce the two polarized images.

Abstract: Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed. The present invention further relates to the use of the device for drug target discovery and/or drug development and a method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model.

Abstract: An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor (10) in an aerosol output pathway of the system. A controller (600) determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis.

Abstract: The present invention relates to an integrated electronic-microfluidic device an integrated electronic-microfluidic device, comprising a semiconductor substrate (106) on a first (122) support, an electronic circuit (102, 104) on a first semiconductor-substrate side of the semiconductor substrate, and a signal interface structure to an external device. The signal interface structure is arranged on the first semiconductor-substrate side and configured to receive electrical signals from the electronic circuit. A microfluidic structure (126) is formed in the semiconductor substrate, and is configured to confine a fluid and to allow a flow of the fluid to and from the microfluidic structure only on a second semiconductor-substrate side that is opposite to the first semiconductor-substrate side and faces away form the first support. The electronic-microfluidic device forms a flexible platform for the formation of various System-in-Package applications.

Abstract: Disclosed is a device (100) for cardiac electrophysiology screening comprising a substrate (10) comprising a cavity (42), said substrate carrying a deformable layer (32) extending over said cavity (42), wherein a portion of said deformable layer (32) covers said cavity and acts as a membrane over said cavity (32), said portion having a surface comprising a pattern of grooves (44) and carrying a multi-electrode structure (110, 110?); and a plurality of cardiomyocytes (130) assembled in at least some of said grooves (44). A method of manufacturing such a device (100) is also disclosed.

Abstract: An integrated electronic-micro fluidic device an integrated electronic-micro fluidic device, comprising a semiconductor substrate on a first support, an electronic circuit on a first semiconductor-substrate side of the semiconductor substrate, and a signal interface structure to an external device. A micro fluidic structure is formed in the semiconductor substrate, and is configured to confine a fluid and to allow a flow of the fluid to and from the microfluidic structure only on a second semiconductor-substrate side that is opposite to the first semiconductor-substrate side and faces away from the first support.

Abstract: An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor in an aerosol output pathway of the system. A controller determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis.

Abstract: An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor in an aerosol output pathway of the system. A controller determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis.

Abstract: An apparatus and method for optically detecting the presence of an analyte in a solution is presented. An embodiment comprises a waveguide resonator that is optically coupled to a fluid in a fluidic conduit so that the resonant wavelength of the waveguide resonator is based on the refractive index of the fluid.

Abstract: A method of forming a spectral purity filter having a plurality of apertures configured to transmit extreme ultraviolet radiation and suppress transmission of a second type of radiation, in which trenches are formed in a base material in a pattern corresponding to the walls to be formed between the apertures. The trenches are filled with a grid material to form walls of the grid material, and the base material is selectively removed until the grid material is exposed and forms the spaces between the walls of the grid material for the apertures.

Abstract: A transducer (800) is provided where a membrane (830) is formed over a front substrate (615); and a piezoelectric layer (820) is formed over the membrane (830) at an active portion (821) and peripheral portions located adjacent the active portion (821). A patterned conductive layer including first and second electrodes (840, 845) is formed over the piezoelectric layer (820). Further, a back substrate structure is provided having supports (822, 824) located at the peripheral portions adjacent the active portion (821). The height (826) of the supports (822, 824) is greater than a combined height (828) of the patterned piezoelectric layer and the patterned conductive layer. Many transducers may be connected to form an array, where a controller may be provided for controlling the array, such as steering a beam of the array, and processing signals received by the array, for presence or motion detection and/or imaging, for example.

Abstract: An apparatus and method for optically detecting the presence of an analyte in a solution is presented. An embodiment comprises a waveguide resonator that is optically coupled to a fluid in a fluidic conduit so that the resonant wavelength of the waveguide resonator is based on the refractive index of the fluid.

Abstract: A method of manufacturing an electronic device that comprises a microelectromechanical (MEMS) element, the method comprising the steps of: providing a material layer (34) on a first side of a substrate (32); providing a trench (40) in the material later (34); etching material from the trench (40) such as to also etch the substrate (32) from the first side of the substrate (32); grinding the substrate (32) from a second side of the substrate to expose the trench (40); and using the exposed trench (40) as an etch hole. The exposed trench (40) is used as an etch hole for releasing a portion of the material layer (34), for example a beam resonator (12), from the substrate (32). An input electrode (6), an output electrode (8), and a top electrode (10) are provided.

Abstract: An elongate device (e.g. a catheter) for interventional MRI has one or more passive LC-circuits (wireless markers) attached to its distal tip portion for position tracking. The LC-circuits comprise an inductor winding (480) and a three-dimensional “trench” capacitor (420-440) and are integrated in a piece of silicon (410). Optical fibres may be included in the device for optical probing of tissue surrounding the distal tip portion.

Abstract: A scanning projector for projecting an image comprising multiple wavelength signals is disclosed. Embodiments of the present invention include a beam combiner comprising a planar lightwave circuit having a plurality of surface waveguides arranged to define a plurality of input ports, a mixing region, and an output port. Each input port receives a different wavelength signal and provides it to the mixing region. The mixing region combines the plurality of wavelength signals into a single composite output beam that is scanned over a region to create an image in a region. In some embodiments, the projector (1) interrogates image points in the region using a first wavelength signal to determine a measurand and (2) projects an image over the image points of the region using a second wavelength signal, wherein each image point is illuminated with the second wavelength signal based on a measurand at that image point.

Abstract: A thermal flow sensor integrated circuit for sensing flow in a channel based on temperature measurements, the integrated circuit having a temperature sensing element (30) on a front side of the integrated circuit arranged to face the channel, and a bond pad (60, 200) coupled electrically to the temperature sensing element, for making electrical contact off the integrated circuit, the bond pad being arranged to face away from the channel. By having the bond pad facing away from the channel, the space needed for the bond pad and any connections to it need not extend beyond the temperature sensing element and get in the way of the channel. Hence the temperature sensing element can be located closer to the channel or in the channel to enable measurements with better response time and sensitivity.

Abstract: There is provided a fall detector for detecting falls of a user or an object to which the fall detector is attached, characterized in that the fall detector comprises an air flow sensor for providing measurements indicative of vertical velocity and/or changes in altitude of the fall detector.

Abstract: Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed. The present invention further relates to the use of the device for drug target discovery and/or drug development and a method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model.