Abstract: A planar Vivaldi antenna array, and method of forming such an array, the array comprising: a plurality of slots at an end of the antenna array, the slots extending through the whole thickness of the planar structure of the antenna array; and a plurality of grooves extending from the slots; wherein: the grooves do not extend through the whole thickness of the planar structure of the antenna array; and the cross-sectional shape of the grooves is complementary to the cross-sectional shape of the slots.

Abstract: A radar or other microwave antenna comprises at least one antenna element, a feed structure for the element extending to the antenna element substantially normally thereto through a dielectric substrate, and characterised in that the dielectric substrate is anisotropic whereby to reduce unwanted common-mode currents in the feed structure. The anisotropy may be provided by elongate conductive elements distributed through the dielectric substrate and aligned with their longitudinal axes parallel to the feed structure.

Abstract: Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.

Abstract: A digital notification and response system for digitally notifying customers of an utility. The system includes a plurality of user contact devices, an application programming interface, and a dynamic information database. Real time digital user data comprising bank identified grouping information for forming user groups, user contact device information for each contact device, and utility provided user contact device priority information is received by the application programming interface and stored in the dynamic information database. The user contact device priority information is used to form a first and second group of user contact devices. Messages are transmitted through at least two industry standard gateways to the user contact devices, wherein the messages are simultaneously transmitted to the first group of user contact devices before the second group of user contact devices.

Abstract: Conjugates of an active substance and hydroxyalkyl starch (HAS) are provided herein. The active substance and the HAS are linked by a chemical moiety having a structure according to formula (I) wherein Y is O or S, and X is SH or (F). The conjugate has a structure according to formula (IV) wherein HAS? is a residue of HAS or a derivative thereof linked to the thioester group, and AS? is a residue of the active substance or derivative thereof linked to the alpha-X beta-amino group; or a structure according to formula (V) wherein HAS? is a residue of HAS or derivative thereof linked to the alpha-X beta-amino group, and AS? is a residue of the active substance or derivative thereof linked to the thioester group, and wherein the group —(C?Y) is derived from the thioester group —(C?Y)—S—R? and the group HN—CH—CH2—X is derived from the alpha-X beta amino group.

Abstract: The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.

Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.

Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.

Abstract: Conjugates of an active substance and hydroxyalkyl starch (HAS) are provided herein. The active substance and the HAS are linked by a chemical moiety having a structure according to formula (I) wherein Y is O or S, and X is SH or (F). The conjugate has a structure according to formula (IV) wherein HAS? is a residue of HAS or a derivative thereof linked to the thioester group, and AS? is a residue of the active substance or derivative thereof linked to the alpha-X beta-amino group; or a structure according to formula (V) wherein HAS? is a residue of HAS or derivative thereof linked to the alpha-X beta-amino group, and AS? is a residue of the active substance or derivative thereof linked to the thioester group, and wherein the group —(C?Y) is derived from the thioester group —(C?Y)—S—R? and the group HN—CH—CH2—X is derived from the alpha-X beta amino group.

Abstract: An apparatus is provided for establishing at least two open access door positions relative to an opening of a compartment. The apparatus includes a position defining member having at least one engagement element, and a stop member. The position defining member is adapted to be coupled to the compartment. A housing member is adapted to be coupled to the access door for movement therewith, and has an opening for translatable receipt of the position defining member. The housing member further includes an engagement element operable to engage the at least one engagement element of the position defining member to establish a first open access door position. The stop member contacting the housing member establishes a second open access door position approximately perpendicular to the compartment.

Abstract: The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular Argyrin and derivatives thereof, preferably Argyrin A, for the treatment of proliferative diseases, such as cancer, as well as the derivatization of said macrocycles.

Abstract: A digital notification and response system utilizing an administrator interface to transmit a message from an administrator to a user contact device. The system comprises a dynamic information database that includes user contact data, priority information, and response data. The administrator initiates distribution of the message based upon grouping information, priority information, and the priority order. The message is transmitted through at least two industry standard gateways simultaneously to groups of user contact devices based upon priority information. Once the message is received by the user contact device, the user contact device transmits a response through the industry standard gateways back to the dynamic information database.

Abstract: A method for preparing a conjugate comprising a glycoprotein and a polymer or a derivative of said polymer, wherein the polymer is a hydroxyalkylstarch (HAS), the method comprising the steps a) reacting said glycoprotein with a modified polyol carrying attached thereto, by a covalent linkage, a functional group Z, in the presence of a transferase capable of catalysing formation of a covalent linkage between the glycoprotein and said modified polyol, yielding a glycoprotein covalently linked to a polyol carrying attached thereto, by a covalent linkage, at least one functional group Z, and b) reacting at least one functional group A of the polymer or the derivative thereof with the at least one functional group Z of the glycoprotein added to said glycoprotein during step a), and thereby forming a covalent linkage.

Abstract: A method for digitally notifying customers of a utility. The method includes receiving real time digital user data from a utility using an application programming interface in communication with a processor and a network, and storing the real time digital user data in a dynamic information database in communication with the processor. At least one message is transmit from the utility through the application programming interface to a first group of user contact devices before transmitting the message to a second group of user contact devices. Response information is received from each user contact device.

Abstract: A device is disclosed comprising a contour configured to engage a foot and supported by a response assembly, the response assembly configured to mechanically respond to pressure applied to the contour. The contour may comprise at least one stimulating mound configured to engage at least one non-medial arch of the foot and/or a heel ridge for dividing the heel from the rest of the foot. A control circuit is disclosed that may communicate with an orthopedic device to create a pressure reading used to control a point of response and/or a stimulating mound. The device may include a second contour configured to engage a second foot supported by a second response assembly. Methods of using the device are disclosed. The device may be an orthopedic device and/or a sports training device. A shoe insert and shoe are disclosed, each comprising a contour including at least one stimulating mound.

Abstract: A drink mix system includes a disk having first and second additives, an additional additive coated on an end wall of a threaded bottle cap, and a seal. The disk is adapted to be self-retaining within a bottle cap. The additives are sandwiched between the seal and the end wall when in a sealed position such that liquid within a bottle can not contact the additives when the cap is mated to the bottle. Alternatively, rather than a disk, a bullet-shaped nugget having an outer additive layer and an inner additive layer is sandwiched between the seal and the end wall of the cap. When desired, a user removes the seal and selectively mixes one or more of the additives with the liquid in the bottle. This results in an inexpensive drink mix system that can utilize standard bottle caps and allows a user to selectively flavor a beverage.

Abstract: A method to provide a digital notification and response to groups of users comprising storing user contact data for at least one group of users, user selected priority information, and user selected grouping information in a dynamic information database, and using an administrator interface to form at least one message. An administrator initiates transmission of the message simultaneously to a first group of user contact devices for all users in the at least one group of users, then simultaneously to a second group of user contact devices, using the user selected priority information. The administrator interface is used to ensure each user is contacted on the first group of user contact devices before the second group of user contact devices. Responses are received from the user contact devices indicating the devices that received the message and when insufficient user contact device information exists to contact the user contact devices.

Abstract: A method to provide a digital notification and response to groups of users comprising storing user contact data for at least one group of users, user selected priority information, and user selected grouping information in a dynamic information database, and using an administrator interface to form at least one message. An administrator initiates transmission of the message simultaneously to a first group of user contact devices for all users in the at least one group of users, then simultaneously to a second group of user contact devices, using the user selected priority information and transmitting the message through at least two industry standard gateways simultaneously. The administrator interface is used to ensure each user is contacted on the first group of user contact devices before the second group of user contact devices using the user selected priority information.

Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.