Patents by Inventor Ronald Graham

Ronald Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230160001
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: May 6, 2021
    Publication date: May 25, 2023
    Inventors: Ada Tong, Ronald Graham, Megha Cila, Eli N. Glezer, Zachary Terranova
  • Publication number: 20230119408
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Application
    Filed: August 12, 2022
    Publication date: April 20, 2023
    Inventors: Ronald Graham, Surya Adhikari, Ada Tong, Zachary Terranova
  • Publication number: 20230101281
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Application
    Filed: August 5, 2022
    Publication date: March 30, 2023
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • Publication number: 20230028359
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: October 24, 2019
    Publication date: January 26, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Publication number: 20230002436
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 5, 2023
    Inventors: Ronald Graham, Surya Adhikari, Rodrigo Rodriguez, Zachary Terranova
  • Patent number: 11535754
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: December 27, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • Publication number: 20220332752
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: January 7, 2020
    Publication date: October 20, 2022
    Applicant: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Publication number: 20220315614
    Abstract: Disclosed herein, inter alia, are reducing agents and methods of use thereof.
    Type: Application
    Filed: March 18, 2022
    Publication date: October 6, 2022
    Inventors: Ronald Graham, Zachary Terranova
  • Publication number: 20220298201
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
    Type: Application
    Filed: February 20, 2019
    Publication date: September 22, 2022
    Inventors: Ronald Graham, Andrew Spaventa, Eli Glezer
  • Publication number: 20220267603
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • Publication number: 20220127299
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: January 7, 2020
    Publication date: April 28, 2022
    Applicant: LG Electronics Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Patent number: 11174281
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: November 16, 2021
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Surya Adhikari, Rodrigo Rodriguez, Zachary Terranova
  • Patent number: 10822653
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: November 3, 2020
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Publication number: 20200340051
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: January 7, 2020
    Publication date: October 29, 2020
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Patent number: 10738072
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: August 11, 2020
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Patent number: 10487357
    Abstract: In some embodiments, the disclosure relates generally to methods, as well as related, systems, compositions, kits and apparatuses, for nucleic acid analysis that involve the use of modified nucleotides, including terminator nucleotides and/or tagged nucleotides, in a template-dependent nucleotide incorporation reaction. In some embodiments, the nucleic acid analysis can be conducted at a single reaction site, or at a plurality of reaction sites in an array of reaction sites. Optionally, the array contains a plurality of reaction sites having about 1-100 million, or about 100-250 million, or about 200-500 million, or about 500-900 million, or more reaction sites. Optionally, each reaction site is in contact with, operatively coupled, or capacitively coupled to one or more sensors that are ion-sensitive FETs (isFETs) or chemically-sensitive FETs (chemFETs) sensors. Optionally, the reaction sites are in fluid communication with each other.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: November 26, 2019
    Assignees: Life Technologies Corporation, Life Technologies GmbH
    Inventors: Wolfgang Hinz, Steven Menchen, Ronald Graham, Peter Vander Horn, Earl Hubbell, Christian Woehler, Roman Rozhkov, Barnett Rosenblum
  • Publication number: 20190352508
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 21, 2019
    Inventors: Ronald Graham, Rodrigo Rodriguez
  • Publication number: 20190077726
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of synthesizing labeled nucleosides.
    Type: Application
    Filed: September 13, 2018
    Publication date: March 14, 2019
    Inventors: Ronald Graham, Andrew Spaventa
  • Publication number: 20180119217
    Abstract: In some embodiments, the disclosure relates generally to methods, as well as related, systems, compositions, kits and apparatuses, for nucleic acid analysis that involve the use of modified nucleotides, including terminator nucleotides and/or tagged nucleotides, in a template-dependent nucleotide incorporation reaction. In some embodiments, the nucleic acid analysis can be conducted at a single reaction site, or at a plurality of reaction sites in an array of reaction sites. Optionally, the array contains a plurality of reaction sites having about 1-100 million, or about 100-250 million, or about 200-500 million, or about 500-900 million, or more reaction sites. Optionally, each reaction site is in contact with, operatively coupled, or capacitively coupled to one or more sensors that are ion-sensitive FETs (isFETs) or chemically-sensitive FETs (chemFETs) sensors. Optionally, the reaction sites are in fluid communication with each other.
    Type: Application
    Filed: March 18, 2016
    Publication date: May 3, 2018
    Applicants: Life Technologies Corporation, Life Technologies GmbH
    Inventors: Wolfgang HINZ, Steven MENCHEN, Ronald GRAHAM, Peter VANDER HORN, Earl HUBBELL, Christian WOEHLER, Roman ROZHKOV, Barnett ROSENBLUM
  • Patent number: 9796005
    Abstract: A method of forming an article from an ??? titanium including, in weight percentages, from about 2.9 to about 5.0 aluminum, from about 2.0 to about 3.0 vanadium, from about 0.4 to about 2.0 iron, and from about 0.2 to about 0.3 oxygen. The method comprises cold working the ??? titanium alloy.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: October 24, 2017
    Assignee: ATI PROPERTIES LLC
    Inventors: John J. Hebda, Randall W. Hickman, Ronald A. Graham