Patents by Inventor Ronald Graham

Ronald Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cleavable disulfide linkers and uses thereof
    Patent number: 11946103
    Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.
    Type: Grant
    Filed: August 14, 2023
    Date of Patent: April 2, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Megha Cila
  • Nucleotide analogues
    Patent number: 11878993
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: January 23, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • CLEAVABLE DISULFIDE LINKERS AND USES THEREOF
    Publication number: 20230407389
    Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.
    Type: Application
    Filed: August 14, 2023
    Publication date: December 21, 2023
    Inventors: Ronald Graham, Megha Cila
  • SILICON CONTAINING DETECTABLE COMPOUNDS
    Publication number: 20230295437
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.
    Type: Application
    Filed: April 3, 2023
    Publication date: September 21, 2023
    Inventors: Ronald Graham, Rodrigo Rodriguez
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230257414
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: April 4, 2023
    Publication date: August 17, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • SILICON CONTAINING MODIFIED NUCLEOTIDE ANALOGS
    Publication number: 20230242571
    Abstract: Disclosed herein, inter alia, are silicon containing cleavable linkers and compounds for use in nucleic acid sequencing.
    Type: Application
    Filed: February 1, 2023
    Publication date: August 3, 2023
    Inventors: Ronald Graham, Zachary Terranova
  • Silicon containing detectable compounds
    Patent number: 11697736
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: July 11, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Rodrigo Rodriguez
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230203083
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: March 6, 2023
    Publication date: June 29, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • METHODS AND COMPOSITIONS USEFUL FOR NUCLEIC ACID SEQUENCING
    Publication number: 20230193361
    Abstract: Disclosed herein, inter alia, are modified nucleotides and methods of using the same in nucleic acid sequencing reactions.
    Type: Application
    Filed: October 28, 2022
    Publication date: June 22, 2023
    Inventors: Eli N. Glezer, Ronald Graham, Michael Krause
  • NUCLEOTIDE CLEAVABLE LINKERS WITH RIGID SPACERS AND USES THEREOF
    Publication number: 20230160001
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: May 6, 2021
    Publication date: May 25, 2023
    Inventors: Ada Tong, Ronald Graham, Megha Cila, Eli N. Glezer, Zachary Terranova
  • NUCLEOTIDE ANALOGS AND USES THEREOF
    Publication number: 20230119408
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Application
    Filed: August 12, 2022
    Publication date: April 20, 2023
    Inventors: Ronald Graham, Surya Adhikari, Ada Tong, Zachary Terranova
  • SILICON CONTAINING DETECTABLE COMPOUNDS AND USES THEREOF
    Publication number: 20230101281
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Application
    Filed: August 5, 2022
    Publication date: March 30, 2023
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230028359
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: October 24, 2019
    Publication date: January 26, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • MODIFIED NUCLEOTIDES AND USES THEREOF
    Publication number: 20230002436
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 5, 2023
    Inventors: Ronald Graham, Surya Adhikari, Rodrigo Rodriguez, Zachary Terranova
  • Silicon containing detectable compounds and uses thereof
    Patent number: 11535754
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: December 27, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF
    Publication number: 20220332752
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: January 7, 2020
    Publication date: October 20, 2022
    Applicant: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • REDUCING AGENTS AND USES THEREOF
    Publication number: 20220315614
    Abstract: Disclosed herein, inter alia, are reducing agents and methods of use thereof.
    Type: Application
    Filed: March 18, 2022
    Publication date: October 6, 2022
    Inventors: Ronald Graham, Zachary Terranova
  • FLUORINATED NUCLEOTIDES AND USES THEREOF
    Publication number: 20220298201
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
    Type: Application
    Filed: February 20, 2019
    Publication date: September 22, 2022
    Inventors: Ronald Graham, Andrew Spaventa, Eli Glezer
  • SILICON CONTAINING DETECTABLE COMPOUNDS AND USES THEREOF
    Publication number: 20220267603
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF
    Publication number: 20220127299
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: January 7, 2020
    Publication date: April 28, 2022
    Applicant: LG Electronics Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez