Abstract: The present disclosure is directed to a filtering element. The filtering element may comprise at least one channel defined by at least one wall. The at least one wall extends longitudinally from a first end of the channel to a second end of the channel, the at least one channel having an unobstructed first end and an unobstructed second end. The filtering element further includes at least one partial barrier configured to reduce a path of a flow of exhaust through the at least one channel, the at least one partial barrier being positioned within the at least one channel so as to redirect a portion of the exhaust flow within the channel. The at least one channel includes a selective catalytic reduction catalyst on at least a portion of one of a surface of the at least one partial barrier or a surface of the at least one wall.

Abstract: An exhaust emission control system for an internal combustion engine is disclosed. The exhaust emission control system has a first passageway and a second passageway disposed to receive exhaust in parallel. The exhaust emission control system also has a valve arrangement configured to regulate the flow of exhaust to the first and second passageways, and at least one sensor configured to sense a parameter indicative of a constituent of the exhaust. The at least one sensor generates a signal corresponding to the sensed parameter. The exhaust emission control system also has a controller in communication with the valve and the at least one sensor. The controller is configured to affect operation of the valve in response to the signal.

Abstract: Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme substrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell.

Abstract: A multi-celled chip. The chip includes a plurality of hexagonal cells arranged in an array. A plurality of interconnects including Y's connect the cells in clusters of three cells each, so that each of the cells is interconnected.

Abstract: An exhaust emission control system for an internal combustion engine is disclosed. The exhaust emission control system has a first passageway and a second passageway disposed to receive exhaust in parallel. The exhaust emission control system also has a valve arrangement configured to regulate the flow of exhaust to the first and second passageways, and at least one sensor configured to sense a parameter indicative of a constituent of the exhaust. The at least one sensor generates a signal corresponding to the sensed parameter. The exhaust emission control system also has a controller in communication with the valve and the at least one sensor. The controller is configured to affect operation of the valve in response to the signal.

Abstract: Substrate compounds comprising a trigger moiety, a reporter system comprising a plurality of fluorescent moieties, and a multivalent self-immolative dendrimer linker linking the trigger moiety to the reporter system.

Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.

Abstract: Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme stubstrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell.

Abstract: A method of producing metal fibers including melting a mixture of at least a fiber metal and a matrix metal, cooling the mixture to form a bulk matrix comprising at least a fiber phase and a matrix phase and removing at least a substantial portion of the matrix phase from the fiber phase. Additionally, the method may include deforming the bulk matrix. In certain embodiments, the fiber metal may be at least one of niobium, a niobium alloy, tantalum and a tantalum alloy and the matrix metal may be at least one of copper and a copper alloy. The substantial portion of the matrix phase may be removed, in certain embodiments, by dissolving of the matrix phase in a suitable mineral acid, such as, but not limited to, nitric acid, sulfuric acid, hydrochloric acid and phosphoric acid.

Abstract: A multi-celled chip. The chip includes a plurality of hexagonal cells arranged in an array. A plurality of interconnects including Y's connect the cells in clusters of three cells each, so that each of the cells is interconnected.

Abstract: According to one aspect of the present disclosure, a part for an article of equipment includes a fluid conducting first region including a corrosion resistant first material, and a fluid conducting second region including a second material. The first region and the second region are either directly or indirectly joined by solid state welding to form a unitary fluid conducting part. According to another aspect of the present disclosure, a method for replacing at least one fluid conducting part of an article of equipment is disclosed wherein a replacement part is provided that includes a fluid conducting first region including a corrosion resistant first material, and a fluid conducting second region including a second material. The second material is substantially identical to the material of a region of the equipment on which the replacement part is mounted. The first and second regions are either directly or indirectly joined by solid state welding to form a unitary fluid conducting replacement part.

Abstract: Substrate compound-containing micelles and various compositions, kits and methods for their preparation and use are provided.

Abstract: Ligand-containing micelles and various compositions, kits and methods for their preparation and use are provided.

Abstract: In one aspect, the present disclosure relates to methods for detecting an activity of an enzyme in a cell. In some embodiments, the methods include contacting a cell with a liposome containing at least one substrate thereby facilitating introduction of the substrate into the cell. The substrate is capable of producing a detectable light signal when acted on by the enzyme, and the signal is detected. The methods can be used in screening agents that can inhibit or activate an enzyme activity. The methods can also be used in various downstream assays such the detection of interactions between intracellular proteins, screening for variants of an enzyme, and detection of various diseases. Compositions and kits for carrying out the various methods are also provided.

Abstract: Disclosed are binding substrate compositions, methods and kits useful for, among other things, detecting and/or characterizing binding interactions between molecules of interest.

Abstract: Bis-diazo,triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides, and polypeptides. The quencher moieties are non-fluorescent and accept energy from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labelled biomolecules for various molecular biology assays based on fluorescence detection.

Abstract: The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.

Abstract: A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R1-R6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group, or, when taken together, R1 and R6 is benzo, or, when taken together, R4 and R5 is benzo; R7-R10, R12-R16 and R18 may be hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group; R11 and R17 may be hydrogen, lower alkyl, lower alkene, lower alkyne, phenyl, aryl, linking group; Y1-Y4 are hydrogen, lower alkyl, or cycloalkyl, or, when taken together, Y1 and R2, Y2 and R1 Y3 and R3, and/or Y4 and R4 is propano, ethano, or substituted forms thereof, and X1-X3 taken separately are hydrogen, chlorine, fluorine, lower alkyl, carboxylate, sulfonate, hydroxymethyl, and linking group, or any combinations thereof.

Abstract: A system and method for remote pharmacy order processing is described. Orders from hospitals are transmitted to a site for centralized order queue management. Each order is identified and added to a queue for the originating hospital. Orders are reviewed and authorized at remote order processing centers by licensed pharmacy personnel. Computers at the remote order processing centers are linked to hospital pharmacy information systems. A pharmacist at a remote order processing center selects a hospital, reviews orders from the queue for the selected hospital, and enters them directly into the hospital's pharmacy information system. The present invention also supports service level tracking and alerts for aging orders. Commitments are specified in service level agreements. The center then processes the orders according to the commitments. Hospital specific clinical initiatives and policies are stored in a central data repository and made available to personnel to ensure hospital policy compliance.

Abstract: The present disclosure provides methods, compositions, and kits for carrying out phospholipase assays. In some aspects, the methods comprise the use of a lipid complex comprising a fluorescently-labeled phospholipase substrate and detecting an increase in fluorescence due to phospholipase-mediated cleavage of the substrate.