Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

Abstract: In some embodiments, the disclosure relates generally to methods, as well as related, systems, compositions, kits and apparatuses, for nucleic acid analysis that involve the use of modified nucleotides, including terminator nucleotides and/or tagged nucleotides, in a template-dependent nucleotide incorporation reaction. In some embodiments, the nucleic acid analysis can be conducted at a single reaction site, or at a plurality of reaction sites in an array of reaction sites. Optionally, the array contains a plurality of reaction sites having about 1-100 million, or about 100-250 million, or about 200-500 million, or about 500-900 million, or more reaction sites. Optionally, each reaction site is in contact with, operatively coupled, or capacitively coupled to one or more sensors that are ion-sensitive FETs (isFETs) or chemically-sensitive FETs (chemFETs) sensors. Optionally, the reaction sites are in fluid communication with each other.

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of synthesizing labeled nucleosides.

Abstract: In some embodiments, the disclosure relates generally to methods, as well as related, systems, compositions, kits and apparatuses, for nucleic acid analysis that involve the use of modified nucleotides, including terminator nucleotides and/or tagged nucleotides, in a template-dependent nucleotide incorporation reaction. In some embodiments, the nucleic acid analysis can be conducted at a single reaction site, or at a plurality of reaction sites in an array of reaction sites. Optionally, the array contains a plurality of reaction sites having about 1-100 million, or about 100-250 million, or about 200-500 million, or about 500-900 million, or more reaction sites. Optionally, each reaction site is in contact with, operatively coupled, or capacitively coupled to one or more sensors that are ion-sensitive FETs (isFETs) or chemically-sensitive FETs (chemFETs) sensors. Optionally, the reaction sites are in fluid communication with each other.

Abstract: A method of forming an article from an ??? titanium including, in weight percentages, from about 2.9 to about 5.0 aluminum, from about 2.0 to about 3.0 vanadium, from about 0.4 to about 2.0 iron, and from about 0.2 to about 0.3 oxygen. The method comprises cold working the ??? titanium alloy.

Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.

Abstract: A method for making a tube is described in which a multi-layer billet is extruded to provide a tube having a wall comprising an inner layer metallurgically bonded to an outer layer.

Abstract: A power system includes a dual fuel engine, a first fuel source configured to provide a first fuel to the engine, and a second fuel source configured to provide a second fuel to the engine different than the first fuel. The power system also includes an exhaust system configured to receive combustion exhaust from the engine. The exhaust system includes a reduction catalyst comprising palladium catalyst material and an oxidation catalyst comprising cobalt catalyst material. Additionally, changing a ratio of the first fuel provided to the engine relative to the second fuel changes a NOx conversion efficiency of the reduction catalyst.

Abstract: An engine system includes an electronically controlled compression ignition engine configured to burn diesel fuel to produce an exhaust with a temperature and NOx to soot ratio. An aftertreatment system is fluidly connected to the engine and includes a diesel oxidation catalyst, a reductant supply, and a diesel particulate filter coated with a NOx reduction catalyst but not the diesel oxidation catalyst. A soot load density in the diesel particulate filter is stabilized by oxidizing soot at about a same rate as the compression ignition engine is supplying soot to the aftertreatment system without active regeneration. A NOx reduction reaction is catalyzed by the NOx reduction catalyst on the diesel particulate filter.

Abstract: A method for making a tube is described in which a multi-layer billet is extruded to provide a tube having a wall comprising an inner layer metallurgically bonded to an outer layer.

Abstract: A treatment device configured to receive a flow of exhaust from a power source is disclosed. The treatment device may have a first layer, a second layer, and a substrate layer. The first layer may include a selective catalytic reduction layer, and the second layer may be disposed downstream of the first layer and include an oxidation catalyst support. The substrate layer may be disposed adjacent to the second layer. Additionally, an additive may be disposed downstream of the first layer. The additive may be operative to substantially prohibit migration of a component of the second layer to the first layer upon treatment of the flow of exhaust by the oxidation catalyst support.

Abstract: According to one aspect of the present disclosure, a part for an article of equipment includes a fluid conducting first region including a corrosion resistant first material, and a fluid conducting second region including a second material. The first region and the second region are either directly or indirectly joined by solid state welding to form a unitary fluid conducting part. According to another aspect of the present disclosure, a method for replacing at least one fluid conducting part of an article of equipment is disclosed wherein a replacement part is provided that includes a fluid conducting first region including a corrosion resistant first material, and a fluid conducting second region including a second material. The second material is substantially identical to the material of a region of the equipment on which the replacement part is mounted. The first and second regions are either directly or indirectly joined by solid state welding to form a unitary fluid conducting replacement part.

Abstract: A method, apparatus, or system for generating a pattern of polynucleotides on a substrate. The method includes providing a substrate having a hydrophobic surface. The method further includes conjugating a polystyrene moiety to a polynucleotide and applying a polystyrene-polynucleotide conjugate to create a plurality of reaction spots on the hydrophobic surface of the substrate. An apparatus includes a substrate with at least one polystyrene-polynucleotide conjugate on a surface of the substrate. A system can analyze a polystyrene-polynucleotide conjugate and the system may perform PCR.