Abstract: Methods of treating autoimmune diseases, such as systemic lupus erythematosus using domain antibodies that specifically bind human CD28 are provided. The methods may comprise at least one administration cycle comprising one dose of the domain antibody. The method reduces symptoms of systemic lupus erythematosus compared to placebo.

Abstract: A display method and an electronic apparatus include a display unit with various kinds of different display modes, so that when the current display mode of the display unit is the first display mode, the first application in the electronic apparatus is initiated, and then the electronic apparatus detects the first parameter information of the first application, and then determines the correspondence relationship between the first parameter information and the display modes, determines the second display mode corresponding to the first parameter information, and adjusts the display unit from the first display mode displayed currently to the second display mode at last. Determining the display modes according to different applications running in the electronic apparatus increases the display effect of the electronic apparatus and reduces the power consumption of the display of the electronic apparatus.

Abstract: A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain antibody (dAb) comprising a single VL or VH domain and an Fc domain.

Abstract: Disclosed are a method for multi-picture control in a video conference, a related device, and a storage medium. An MCU supports a multi-site video conference; and in the method, the process executed by the MCU comprises: when a conference is initially started, the MCU sending unified conference site picture information to a video terminal in each conference site; and during the conference, the MCU sending corresponding customized conference site picture information to some video terminals according to conference site picture customization requests of the video terminals.

Abstract: Disclosed are flashlights that optimize the light output and beam focus of both a flood beam and a spot beam. The disclosed flashlights include a housing member and a lens including a first focusing element adapted to shape a light beam into a spot beam and a second focusing element adapted to shape a light beam into a flood beam. A first LED is positioned to direct light through the first focusing element, and a second LED positioned to direct light through the second focusing element. The first LED has a smaller die than the second LED, and the distance between the first LED and the first focusing element is greater than the distance between the second LED and the second focusing element.

Abstract: A display method and an electronic apparatus include a display unit with various kinds of different display modes, so that when the current display mode of the display unit is the first display mode, the first application in the electronic apparatus is initiated, and then the electronic apparatus detects the first parameter information of the first application, and then determines the correspondence relationship between the first parameter information and the display modes, determines the second display mode corresponding to the first parameter information, and adjusts the display unit from the first display mode displayed currently to the second display mode at last. Determining the display modes according to different applications running in the electronic apparatus increases the display effect of the electronic apparatus and reduces the power consumption of the display of the electronic apparatus.

Abstract: Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.

Abstract: Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.

Abstract: A detection method of blood plasma schizadrin B of dissipating blood stasis botanical is disclosed. The method includes: (1) extracting schizadrin B from plasma of mammalian administered dissipating blood stasis botanical by ethyl acetate with the volume ratio 1:4, whirling 3-5 mins, centrifugating at 9600 rpm for 10 mins, drying and enriching the upper layer at 25-30° C., and redissolving with mobile phase; (2) UPLC/MS measuring: UPLC condition: chromatographic column: Acquity UPLC BEH C18, 2.1?100 mm, mobile phase A: water-acetonitrile-formic acid 95:5:0.1 v/v/v, mobile phase B: acetonitrile-formic acid 100:0.1 v/v; MS condition: electric spraying ion source (ESI), detecting with positive ion mode, scanning at the range of m/z 150-1200. The method can be used for pharmacokinetics study of schizadrin B in dissipating blood stasis botanical.

Abstract: A detection method of blood plasma schizadrin B of dissipating blood stasis botanical is disclosed. The method includes: (1) extracting schizadrin B from plasma of mammalian administered dissipating blood stasis botanical by ethyl acetate with the volume ratio 1:4, whirling 3-5 mins, centrifugating at 9600 rpm for 10 mins, drying and enriching the upper layer at 25-30° C., and redissolving with mobile phase; (2) UPLC/MS measuring: UPLC condition: chromatographic column: Acquity UPLC BEH C18, 2.1?100 mm, mobile phase A: water-acetonitrile-formic acid 95:5:0.1 v/v/v, mobile phase B: acetonitrile-formic acid 100:0.1 v/v; MS condition: electric spraying ion source(ESI), detecting with positive ion mode, scanning at the range of m/z 150-1200. The method can be used for pharmacokinetics study of schizadrin B in dissipating blood stasis botanical.

Abstract: The present invention relates to chromogenic (calorimetric) in situ hybridization (CISH) and nucleic acid probes useful for in situ hybridization. Specifically, the present invention provides methods, kits, and compositions for performing bright field cancer diagnostics employing chromogenic in situ hybridization (e.g. to detect gene amplifications, gene translocations, and chromosome polysomy). In preferred embodiments, the present invention provides CISH methods, kits and compositions for detecting HER2 gene status.

Abstract: The present invention relates to chromogenic (calorimetric) in situ hybridization (CISH) and nucleic acid probes useful for in situ hybridization. Specifically, the present invention provides methods, kits, and compositions for performing bright field cancer diagnostics employing chromogenic in situ hybridization (e.g. to detect gene amplifications, gene translocations, and chromosome polysomy). In preferred embodiments, the present invention provides CISH methods, kits and compositions for detecting HER2 gene status.

Abstract: A preloaded spring assembly is provided in a recess in each shroud in axial opposition to an aft facing sealing surface of a turbine nozzle retaining ring. Each spring assembly includes a spring, preferably a bellows type spring, with a plate mounted on one side and a sealing surface on the side of the plate remote from the spring. The sealing surface may be an abradable coating or a honeycomb seal. The seal assembly is maintained preloaded by a wrap which upon reaching turbine operating temperature disintegrates, enabling the spring to load the sealing surface against the retaining ring surface to prevent or minimize air leakage from outside the nozzle retainer ring into the hot gas path.

Abstract: A preloaded spring assembly is provided in a recess in each shroud in axial opposition to an aft facing sealing surface of a turbine nozzle retaining ring. Each spring assembly includes a spring, preferably a bellows type spring, with a plate mounted on one side and a sealing surface on the side of the plate remote from the spring. The sealing surface may be an abradable coating or a honeycomb seal. The seal assembly is maintained preloaded by a wrap which upon reaching turbine operating temperature disintegrates, enabling the spring to load the sealing surface against the retaining ring surface to prevent or minimize air leakage from outside the nozzle retainer ring into the hot gas path.

Abstract: The present invention provides methods for diagnosing and treating cancer, and in particular methods for determining the susceptibility of subjects suspected of having breast cancer (or known to have breast cancer) to treatment with topoisomerase II inhibitors. The present invention also provides in situ hybridization probes for specifically detecting topoII? gene sequences.

Abstract: A method of allocating an address to a mobile station operating in a wireless communication system is described in order to facilitate a communication link to a fixed communication system. The method is characterised by the steps of receiving (100) an address mapping inquiry from the fixed communication system; locating (102) a respective terminal identifier (58) of the mobile station in response to the supplied address mapping inquiry; and determining whether an address has been allocated for the mobile station. If an address has not been allocated to the mobile station, an address allocation request (112) is activated and an address corresponding to the respective terminal identifier (58) of the mobile station is allocated.

Abstract: A method of routing to a mobile station in a packet switched network arrangement. The method includes forming an initial packet switching route to a mobile station, extending the initial route to form an extended packet switching route, and forming a new packet switching route to replace the extended route dependent on a fall in level of quality of service parameter achieved over the extended route. The initial route is to a first cellular communications gateway and the extended and replacement routes are to a second cellular communications gateway. Also described is corresponding apparatus for routing. Also described is a storage medium storing processor implementable instructions and a signal carrying processor-implementable instructions.

Abstract: A method for restoring immunoreactivity of a tissue, particularly decalcified tissue, fixed width an aldehyde fixative agent and embedded in an embedding medium, usually comprising celloidin, the method comprising the steps of contacting the tissue with an aldehyde releasing reagent solution comprising a solvent and an aldehyde releasing reagent and removing aldehyde released by the aldehyde releasing reagent from contact with the tissue by reacting the aldehyde in a substantially irreversible manner to form a non-aldehyde derivative, and removing excess base from the tissue. A preferred solution for celloidin-embedded decalcified tissue comprises methanolic sodium hydroxide at about one-third saturation.