Abstract: The embodiments herein provide methods to analyze the in vitro stability of recalcitrant or membrane-bound proteins in simulated gastric fluid (SGF) comprising the proteolytic enzyme, pepsin, and in combination with a novel pepsin-trypsin assay employing state-of-the-art mass spectrometric approaches, such as LC-MS/MS, to monitor the precise degradation products. The extent of protein digestion can be evaluated by the appearance of peptic products and the disappearance of tryptic peptide products (as a proxy for intact protein). The embodiments herein also provide methods for protein quantitation using high-sensitivity LC-MRM-MS quantification. The methods embodied herein are particularly useful in charactering proteins produced in transgenic plants, such as canola genetically engineered to produce long chain omega-3 polyunsaturated fatty acids.

Abstract: A method and a device for joint suppression of narrowband and multiple access interference are provided. The method includes: performing time domain windowing processing on a received signal, and performing frequency domain interference processing on a signal after windowing processing to obtain a matched filter and a time domain signal; obtaining reconstructed baseband received data for a signal of each channel; obtaining reconstructed signals after matched filtering; accumulating the reconstructed signals of multiple channels to obtain a reconstructed accumulated value, obtaining a compensation value according to a difference between the time domain signal and the reconstructed accumulated value, and compensating the reconstructed signals with the compensation value to obtain an actual received signal of the each channel; and outputting a joint suppression result.

Abstract: An array substrate, a display panel and a manufacturing method thereof are provided. The array substrate includes data lines, gate lines, a gate driving structure electrically connected with the gate lines and the gate driving signal lines, gate driving signal lines and a data fanout wiring region. The array substrate further includes a dummy fanout wiring region, a dummy pad region and a bended line, the data fanout wiring region and the dummy fanout wiring region are located at both sides of the display region, the data lines are electrically connected with pads in the dummy pad region through the wires in the dummy fanout wiring region; the gate driving signal lines are electrically connected with pads in the dummy pad region; a transmission line is disposed at one side of the gate driving structure away from the display region and electrically connected with the bended line.

Abstract: An array substrate includes a driving circuit arranged on the base substrate, and the driving circuit includes a pull-up node control circuit, a first pull-down node control circuit, and an output circuit; the pull-up node control circuit controls a potential of the pull-up node; the first pull-down node control circuit controls to write a first control voltage provided by the first control voltage line into the first pull-down node; the output circuit controls the driving signal output terminal to output a driving signal under the control of the potential of the pull-up node; the array substrate also includes a first conductive portion arranged on the base substrate; the first conductive portion is electrically connected to the first control voltage line.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The disclosure herein describes processing consent data and using the processed consent data in workflows. Customer consent data is accessed, wherein the customer consent data includes subject consent instances including associated consent purpose-value pairs. The customer consent data is mapped to a raw consent data schema based on mapping selections made on a mapping UI, wherein the mapping includes mapping consent purpose-value pairs of the consent instances to data columns of the raw consent data schema. Metadata representing one or more consent rules related to the raw consent data schema is generated based on rule selections made on a rule configuration UI and the consent rules are applied to one or more workflows. The disclosure enables consent data in different formats and/or from different sources to be ingested and standardized in a single platform such that consent checking functionality can be provided for applications in a consistent and comprehensive manner.

Abstract: The present invention relates to improved procoagulant antibodies including bispecific antibodies capable of binding to coagulation Factor IX (FIX) or the activated form thereof Factor IXa (FIXa) and optionally Factor X (FX) and the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A.

Abstract: Provided are a preparation method and use of a novel copper-metal organic framework (Cu-MOF)-derived magnetic Fe3O4@Cu/C composite for antibiotic degradation. The preparation method of the composite includes: compounding a novel Cu-MOF material obtained in a high-pressure reactor with Fe2O3, and then conducting calcination under an inert gas atmosphere to obtain the magnetic Fe3O4@Cu/C composite.

Abstract: Disclosed are a method and a system for analyzing a process load of a car body rack warehouse. The method includes the following steps: collecting initial geometric dimension data of a goods case and the maximum stock mass of the goods case; unifying units of the initial geometric dimension data of the goods case to form second geometric dimension data of the goods case, obtaining the maximum stock weight of the goods case by calculation; determining a goods case length, a goods case width, and a goods case height; calculating a mean value, a standard deviation, and a coefficient of variation of the maximum stock weight of the goods case; determining a process variable load of a car body rack according to a high tantile with the reliability of 0.95. The process variable load of the rack warehouse may be accurately quantified, thereby guiding the engineering design.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: An IN delivery gas-phase impermeable device for delivery between 0.2 mL and 1.0 mL of a medication solution is disclosed. The device includes an injector barrel including a plurality of slit openings disposed circumferentially along the injector barrel, a center guide positioned lengthwise within the injector barrel, a cannula in fluid communication with the medication solution fixed in position by the center guide, and a vial configured to couple with the injector barrel. The vial includes a pliable rubber stopper with multiple seal rings, each seal ring having a geometry configured to form a gas-phase impermeable seal with an internal surface of the vial. The cannula bisects the pliable rubber stopper. The device includes a base configured to reversibly engage with one or more of the slit openings of the injector barrel during actuation of the device, which may involve compression of the base toward the injector barrel.

Abstract: The present invention relates to improved procoagulant antibodies including bispecific antibodies capable of binding to coagulation Factor IX (FIX) or the activated form thereof Factor IXa (FIXa) and optionally Factor X (FX) and the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A.

Abstract: The disclosure herein describes processing consent data and using the processed consent data in workflows. Customer consent data is accessed, wherein the customer consent data includes subject consent instances including associated consent purpose-value pairs. The customer consent data is mapped to a raw consent data schema based on mapping selections made on a mapping UI, wherein the mapping includes mapping consent purpose-value pairs of the consent instances to data columns of the raw consent data schema. Metadata representing one or more consent rules related to the raw consent data schema is generated based on rule selections made on a rule configuration UI and the consent rules are applied to one or more workflows. The disclosure enables consent data in different formats and/or from different sources to be ingested and standardized in a single platform such that consent checking functionality can be provided for applications in a consistent and comprehensive manner.

Abstract: The application discloses an optical cable assembly and an optical cable testing method. The optical cable assembly comprises: an optical cable wire with a test end; a spool for winding the optical cable; a connection assembly has an optical cable connection port and a test port, the connection assembly is configured to connect objects at both ends of the connection assembly, and the test end of the optical cable is connected to the connection assembly as an object at one end of the optical cable connection port, the test port is located at an operable area of the spool, configured to connect the test equipment to form an optical path between the test equipment and the optical cable wire when the optical cable is tested.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 desaturases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.