Abstract: A method for creating a new germplasm of a male sterile crop by gene editing and an application thereof are provided. In this method, the gene editing is performed on an exon region of a Ty-5 gene, and a deletion of DNA sequence is introduced by using a repair mechanism of plants themselves to double-strand breaks (DSBs), causing a loss of function of Ty-5 gene, thereby obtaining a male-sterile character. The method can be applied without being limited by crop categories. After the gene editing is performed on Ty-5 genes of various crops, new germplasms can be quickly obtained. The new germplasms have the same agronomic characters as the previous materials, and only differ in sexual aspect, which effectively solves the problem of the lack of male sterile materials and unstable fertility in natural resources.

Abstract: An integrated circuit (IC) package including ICs with multi-row columnar die interconnects has increased die-to-die (D2D) interconnect density in a conductive layer. Positioning the die interconnects in die interconnect column clusters, that each include a plurality of die interconnect rows and two columns, reduces the linear dimension occupied by the die interconnects and leaves room for more D2D interconnects. A die interconnect column cluster pitch is a distance between columns of adjacent die interconnect column clusters and this distance is greater than a die interconnect pitch between columns within the column clusters. Die interconnects may be disposed in the space between the multi-row column clusters and additional die interconnects can be disposed at the D2D interconnect pitch between the die interconnect column clusters. IC packages with ICs including the multi-row columnar die interconnects have a greater number of D2D interconnects for better IC integration.

Abstract: A diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port constructed and arranged to receive a test strip that includes a flow path for a fluid sample, a sample receiving zone couple to the flow path, a label that specifically binds a target analyte, a detection zone coupled to the flow path and comprising a test region exposed for optical inspection and having an immobilized test reagent that specifically binds the target analyte, and at least one reference feature. The reader is operable to obtain light intensity measurements from exposed regions of the test strip when the test strip is loaded in the port.

Abstract: A lighting or signaling device comprises a first light source and a housing, the housing defining at least a first light exit region and a second light exit region independent of each other, part of light from the first light source exiting as a first light beam from the first light exit region; the lighting or signaling device further comprises a light guide member, which is assigned to the first light source and is positioned and configured to guide a part of the light from the first light source to exit through at least the second light exit region. A motor vehicle is also disclosed.

Abstract: The present invention relates to lipid comprising docosapentaenoic acid and/or docosahexaenoic acid wherein the docosapentaenoic acid and/or docosahexaenoic acid may be preferentially esterified at the sn-2 position of triacylglycerol, and processes for producing and using the lipid.

Abstract: This disclosure provides a target tracking method and apparatus, relate to the field of data processing technologies, and may be used for security protection, assisted driving, and self-driving. The method includes: obtaining a camera target tracking result and a radar target tracking result; and obtaining a target tracking result based on the camera target tracking result and a target model corresponding to the radar target tracking result, where the target model indicates an association relationship between a target in the radar target tracking result and height information of the target.

Abstract: Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg/mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg/mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg/mL sodium citrate dihydrate, 3.3 mg/mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg/mL of sodium metabisulfite, and 4 ?g/mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg/mL of epinephrine and other ingredients.

Abstract: Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg/mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg/mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg/mL sodium citrate dihydrate, 3.3 mg/mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg/mL of sodium metabisulfite, and 4 ?g/mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg/mL of epinephrine and other ingredients.

Abstract: Embodiments of the present invention provide a system for querying a graph based on applying filters to a visual representation of the graph. The system allows complicated graph query operations to be performed with ease visually. During operation, the system obtains data indicating vertices and edges of a graph. The system displays a visual representation of the graph for a user. The system receives, from the user, a command defining a local graph filter comprising a region in the visual representation. The system then filters a representation of the graph, and stores the filtered representation.

Abstract: The disclosure herein describes processing consent data and using the processed consent data in workflows. Customer consent data is accessed, wherein the customer consent data includes subject consent instances including associated consent purpose-value pairs. The customer consent data is mapped to a raw consent data schema based on mapping selections made on a mapping UI, wherein the mapping includes mapping consent purpose-value pairs of the consent instances to data columns of the raw consent data schema. Metadata representing one or more consent rules related to the raw consent data schema is generated based on rule selections made on a rule configuration UI and the consent rules are applied to one or more workflows. The disclosure enables consent data in different formats and/or from different sources to be ingested and standardized in a single platform such that consent checking functionality can be provided for applications in a consistent and comprehensive manner.

Abstract: Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg/mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg/mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg/mL sodium citrate dihydrate, 3.3 mg/mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg/mL of sodium metabisulfite, and 4 ?g/mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg/mL of epinephrine and other ingredients.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids.

Abstract: The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or parts thereof and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A as well as kits, methods of manufacture and methods of use.

Abstract: Embodiments of the present invention provide a system for querying a graph based on applying filters to a visual representation of the graph. The system allows complicated graph query operations to be performed with ease visually. During operation, the system obtains data indicating vertices and edges of a graph. The system displays a visual representation of the graph for a user. The system receives, from the user, a command defining a local graph filter comprising a region in the visual representation. The system then filters a representation of the graph, and stores the filtered representation.

Abstract: System and methods for relational time-series learning are provided. Unlike traditional time series forecasting techniques, which assume either complete time series independence or complete dependence, the disclosed system and method allow time series forecasting that can be performed on multivariate time series represented as vertices in graphs with arbitrary structures and predicting a future classification for data items represented by one of nodes in the graph. The system and methods also utilize non-relational, relational, temporal data for classification, and allow using fast and parallel classification techniques with linear speedups. The system and methods are well-suited for processing data in a streaming or online setting and naturally handle training data with skewed or unbalanced class labels.

Abstract: The present invention relates to an optical element (1), an optical module and a vehicle. The optical element (1) comprises: a light incident section (10) for receiving light directly from a light source; a light exit section (30) having a focal plane (P); and a third section (20) that directs light from the light incident section (10) toward the light exit section (30) in a predetermined manner to generate a predetermined low beam distribution or high beam distribution, where the optical element (1) is implemented integrally.

Abstract: One embodiment of the present invention provides a system for generating a product recommendation. During operation, the system obtains data indicating vertices and edges of a graph. The vertices represent consumers and products and an edge represents an access relationship. The system may receive a query indicating an ego for determining a product recommendation. The system may then traverse the graph from a vertex representing the ego through a plurality of edges to a plurality of vertices representing products. The system may traverse the graph from the plurality of vertices representing products to a plurality of vertices representing other consumers. The system may then traverse the graph from the plurality of vertices representing other consumers to a plurality of vertices representing other products. The system may generate a recommendation that based on the plurality of vertices representing other products.

Abstract: The present embodiments provide a novel DPA-producing Brassica juncea (DPA juncea) line designated as NUBJ1207. The embodiments also provide the seeds, the plants, and the plant parts (including DNA) of DPA juncea line NUBJ1207, as well as to methods for producing a Brassica plant produced by crossing DPA juncea line NUBJ1207 with itself or another Brassica line. These embodiments also provide methods for producing a DPA-producing Brassica plant containing in its genetic material one or more transgenes, and to the transgenic plants and plant parts produced by those methods. These embodiments further provide DPA production lines or breeding lines and plant parts derived from DPA juncea line NUBJ1207, to methods for producing canola lines or plant parts derived from line NUBJ1207, and to the DPA-producing Brassica plants, varieties, and their parts derived from use of those methods.

Abstract: System and methods for relational time-series learning are provided. Unlike traditional time series forecasting techniques, which assume either complete time series independence or complete dependence, the disclosed system and method allow time series forecasting that can be performed on multivariate time series represented as vertices in graphs with arbitrary structures and predicting a future classification for data items represented by one of nodes in the graph. The system and methods also utilize non-relational, relational, temporal data for classification, and allow using fast and parallel classification techniques with linear speedups. The system and methods are well-suited for processing data in a streaming or online setting and naturally handle training data with skewed or unbalanced class labels.