Abstract: A package that includes a substrate comprising a cavity, a first integrated device coupled to the substrate through a first plurality of pillar interconnects and a first plurality of solder interconnects, a second integrated device coupled to the substrate through a second plurality of pillar interconnects and a second plurality of solder interconnects, and a plurality of wire bonds coupled to the first integrated device and the second integrated device, wherein the plurality of wire bonds is located over the cavity of the substrate.

Abstract: An integrated circuit (IC) package including ICs with multi-row columnar die interconnects has increased die-to-die (D2D) interconnect density in a conductive layer. Positioning the die interconnects in die interconnect column clusters, that each include a plurality of die interconnect rows and two columns, reduces the linear dimension occupied by the die interconnects and leaves room for more D2D interconnects. A die interconnect column cluster pitch is a distance between columns of adjacent die interconnect column clusters and this distance is greater than a die interconnect pitch between columns within the column clusters. Die interconnects may be disposed in the space between the multi-row column clusters and additional die interconnects can be disposed at the D2D interconnect pitch between the die interconnect column clusters. IC packages with ICs including the multi-row columnar die interconnects have a greater number of D2D interconnects for better IC integration.

Abstract: One embodiment of the present invention provides a system for generating a product recommendation. During operation, the system obtains data indicating vertices and edges of a graph. The vertices represent consumers and products and an edge represents an access relationship. The system may receive a query indicating an ego for determining a product recommendation. The system may then traverse the graph from a vertex representing the ego through a plurality of edges to a plurality of vertices representing products. The system may traverse the graph from the plurality of vertices representing products to a plurality of vertices representing other consumers. The system may then traverse the graph from the plurality of vertices representing other consumers to a plurality of vertices representing other products. The system may generate a recommendation that based on the plurality of vertices representing other products.

Abstract: The present invention discloses an ultra-rapid PCR detection system, which comprises a temperature control device, a transmission device and a reaction tube fixing device; the temperature control device at least comprises two temperature control modules, wherein at least one of the temperature control modules is a high-temperature module and at least one of the temperature control modules is a low-temperature module; a heating temperature of the high-temperature module is a first preset temperature, and a heating temperature of the low-temperature module is a second preset temperature; the transmission device is in cooperation with the temperature control device and the reaction tube fixing device, so that a reaction tube on the reaction tube fixing device is switched between the high-temperature module and the low-temperature module; the device has a compact structure and the temperature setting of the high-temperature module and the low-temperature module can promote the rising and falling rate of the tempe

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids.

Abstract: A method for creating a new germplasm of a male sterile crop by gene editing and an application thereof are provided. In this method, the gene editing is performed on an exon region of a Ty-5 gene, and a deletion of DNA sequence is introduced by using a repair mechanism of plants themselves to double-strand breaks (DSBs), causing a loss of function of Ty-5 gene, thereby obtaining a male-sterile character. The method can be applied without being limited by crop categories. After the gene editing is performed on Ty-5 genes of various crops, new germplasms can be quickly obtained. The new germplasms have the same agronomic characters as the previous materials, and only differ in sexual aspect, which effectively solves the problem of the lack of male sterile materials and unstable fertility in natural resources.

Abstract: The present invention relates to an optical element (1), an optical module and a vehicle. The optical element (1) comprises: a light incident section (10) for receiving light directly from a light source; a light exit section (30) having a focal plane (P); and a third section (20) that directs light from the light incident section (10) toward the light exit section (30) in a predetermined manner to generate a predetermined low beam distribution or high beam distribution, where the optical element (1) is implemented integrally.

Abstract: A method for creating a new germplasm of a male sterile crop by gene editing and an application thereof are provided. In this method, the gene editing is performed on an exon region of a Ty-5 gene, and a deletion of DNA sequence is introduced by using a repair mechanism of plants themselves to double-strand breaks (DSBs), causing a loss of function of Ty-5 gene, thereby obtaining a male-sterile character. The method can be applied without being limited by crop categories. After the gene editing is performed on Ty-5 genes of various crops, new germplasms can be quickly obtained. The new germplasms have the same agronomic characters as the previous materials, and only differ in sexual aspect, which effectively solves the problem of the lack of male sterile materials and unstable fertility in natural resources.

Abstract: A method of deep graph representation learning includes: deriving a set of base features; and automatically developing, by a processing device, a multi-layered hierarchical graph representation based on the set of base features, wherein each successive layer of the multi-layered hierarchical graph representation leverages an output from a previous layer to learn features of a higher-order.

Abstract: The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or parts thereof and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A as well as kits, methods of manufacture and methods of use.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids.

Abstract: A device and a method for electromagnetic field simulation are provided. The image processing device is to obtain, with a first resolution, a first electromagnetic field simulation result of a simulation region, and to derive a second electromagnetic field simulation result with a second resolution, according to the first electromagnetic field simulation result, using a model trained based on a deep learning method. The second resolution is higher than the first resolution.

Abstract: The present invention relates to improved procoagulant antibodies including bispecific antibodies capable of binding to coagulation Factor IX (FIX) or the activated form thereof Factor IXa (FIXa) and optionally Factor X (FX) and the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A.

Abstract: A vacuum cleaner (10) includes a handle assembly (22) pivotally coupled to a foot (42). The handle assembly (22) includes an air treatment member, an actuator (34) centrally arranged on a rear side of the handle assembly (22) and a cord reel assembly (14) arranged on a front side of the handle assembly (22). The cord reel assembly (14) includes a cord reel (30) and a cord (26) configured to be coupled to an AC power source and provide power to the suction source. The cord reel (30) is switchable between a first state, in which the cord reel (30) winds the cord (26), and a second state, in which the cord reel (30) does not wind. The actuator (34) is moveable between a first position and a second position. In response to the actuator (34) moving from the first position to the second position, the cord reel (30) switches from the second state to the first state.

Abstract: One embodiment provides a system for facilitating a graph search engine. During operation, the system receives, by a server from a client computing device, a search request which includes a user-inputted graph. The system performs a search based on a structure of the user-inputted graph for a plurality of relevant graphs. The system orders the plurality of relevant graphs from a most relevant ranking to a least relevant ranking. The system returns, to the client computing device, the ordered plurality of relevant graphs for display on a user interface of the client computing device, thereby enhancing the search for relevant graphs by allowing the graph search engine to take as an input the user-inputted graph and return as an output the relevant graphs.

Abstract: The present invention relates to feedstuffs for use in aquaculture, as well as methods for producing said feedstuffs. The invention also provides methods for rearing fish and/or crustaceans. In particular, the present invention provides a method of rearing a fish or crustacean, the method comprising feeding the fish or crustacean a feedstuff comprising lipid, the fatty acid of said lipid comprising at least 5.5% (w/w) stearidonic acid (SDA).

Abstract: The present invention relates to extracted lipid with high levels, for example 90% to 95% by weight, oleic acid. The present invention also provides genetically modified plants, particularly oilseeds such as safflower, which can used to produce the lipid. Furthermore, provided are methods for genotyping and selecting plants which can be used to produce the lipid.

Abstract: The embodiments herein provide methods to analyze the in vitro stability of recalcitrant or membrane-bound proteins in simulated gastric fluid (SGF) comprising the proteolytic enzyme, pepsin, and in combination with a novel pepsin-trypsin assay employing state-of-the-art mass spectrometric approaches, such as LC-MS/MS, to monitor the precise degradation products. The extent of protein digestion can be evaluated by the appearance of peptic products and the disappearance of tryptic peptide products (as a proxy for intact protein). The embodiments herein also provide methods for protein quantitation using high-sensitivity LC-MRM-MS quantification. The methods embodied herein are particularly useful in charactering proteins produced in transgenic plants, such as canola genetically engineered to produce long chain omega-3 polyunsaturated fatty acids.

Abstract: A lighting or signaling device (100) comprises a first light source (101) and a housing (110), the housing (110) defining at least a first light exit region (120) and a second light exit region (130) independent of each other, part of light from the first light source (101) exiting as a first light beam from the first light exit region (120); the lighting or signaling device further comprises a light guide member (140), which is assigned to the first light source (101) and is positioned and configured to guide a part of the light from the first light source (101) to exit through at least the second light exit region (130). A motor vehicle is also disclosed.

Abstract: The present invention relates to lipid comprising docosapentaenoic acid and/or docosahexaenoic acid wherein the docosapentaenoic acid and/or docosahexaenoic acid may be preferentially esterified at the sn-2 position of triacylglycerol, and processes for producing and using the lipid.