Abstract: The present invention refers to a method of drilling a marine wellbore with fluid reverse circulation without using drilling riser tubulars. In reverse circulation drilling, the fluid return with gravels occurs inside the drill string (17) and the injection of clean fluid is done through the annular of the well, so that, having a rotating head over the BOP (19), or inside it, the use of riser tubulars as a flow line for the fluid return with gravels is disposed, using instead the drill string (17). For the kill and choke lines, as well as for fluid injection, rigid or flexible lines can be used, eliminating the need to use drilling risers, thus releasing large load capacity and space on the probe. The method of this invention also eliminates the need for large volumes of fluid to fill entire riser tubulars. The entire operation can be done without the need for subsea pumps or concentric columns.

Abstract: A closed-loop feedback system and method of active noise cancellation to maintain a desired operating frequency of a qubit during a quantum computation, even when that frequency is relatively sensitive to flux noise. A series of Ramsey experiments is performed on the qubit to estimate an offset between its actual and desired operating frequencies, and the error is accumulated. After the probing is complete, the accumulated error is supplied to an arbitrary waveform generator that produces a magnetic flux that is coupled to the qubit, thereby tuning the qubit and actively controlling its operating frequency. Having corrected the operating frequency of the qubit and extended its coherence time, the quantum state of the qubit is allowed to evolve according to the computation.

Abstract: Yeast strains are disclosed that are capable of surviving high ethanol concentrations and propagating in high ethanol concentrations. Genes that are involved in ethanol tolerance are disclosed as well.

Abstract: A method includes monitoring a media stream that is streamed over a network at a given media bit-rate in a sequence of traffic bursts. Respective data volumes of one or more traffic bursts of the sequence are estimated, and the given media bit-rate is derived from the estimated data volumes.

Abstract: A processor is configured to receive, from a first device, a plurality of first-direction packets belonging to a flow of communication, pass the first-direction packets to a second device, receive, from the second device, a plurality of second-direction packets belonging to the flow, pass the second-direction packets to the first device, calculate, after receiving each of at least some of the second-direction packets, an estimated in-flight number, by assuming that the second-direction packet acknowledges receipt of a number of the first-direction packets that is based on an estimated average number of received first-direction packets acknowledged by the second-direction packets, the estimated in-flight number being an estimated volume of payload data, contained at least partly in the first-direction packets, that has been passed by the processor to the second device but has not yet been received by the second device, and to regulate the flow, based on the estimated in-flight number.

Abstract: This invention relates to combination therapy of a subject suffering from acromegaly. The method of treatment comprises administration to the subject of a therapeutically effective amount of oral somatostatin receptor ligand (SRL) e.g. octreotide in combination with a therapeutically effective amount of a dopamine agonist and/or a growth hormone receptor antagonist and/or a selective estrogen receptor modulator (SERM) and/or a 2nd somatostatin receptor ligand (SRL).

Abstract: A valve for controlling a fluid flow comprises: (a) a valve body having an internal cavity; (b) a valve stem receivable within the internal cavity; the valve stem having a control portion configured and a tail portion; the control portion having a first diameter thereof; (c) a deformable valve seat carried by the control portion in a coaxial conformal manner; and (d) a ring mountable within the internal cavity. The control portion has a circumferentially arranged area adjacent to the tail portion. The circumferentially arranged area is of a second diameter smaller than the first diameter. The ring is mountable between a nut and the valve seat such that the nut when secured to the valve body presses onto the valve seat such that the valve seat is deformed within a space between the circumferentially arranged area defined by the second diameter and fills the space in a sealed manner.

Abstract: Techniques for detecting malicious activity on an endpoint based on real-time system events are disclosed. In some embodiments, a system/process/computer program product for detecting malicious activity on an endpoint based on real-time system events includes monitoring an endpoint for malicious activity using an endpoint agent, in which the endpoint comprises a local device; detecting malicious activity associated with an application on the endpoint based on real-time system events using the endpoint agent based on a set of rules; and in response to detecting malicious activity on the endpoint based on real-time system events using the endpoint agent, performing a security response based on a security policy.

Abstract: A device receives a packet from a local network. The packet may be directed toward a cloud computing resource. The device determines that the packet is associated with a new packet flow. In response to determining that the packet is associated with the new packet flow, the device provides one or more packets from the new packet flow to a machine learning model for packet inspection. The device receives an output from the machine learning model and routes the new packet flow based on the output received from the machine learning model. The output indicates whether or not the new packet flow is associated with a network attack.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to configure heterogenous components in an accelerator. An example apparatus includes a graph compiler to identify a workload node in a workload and generate a selector for the workload node, and the selector to identify an input condition and an output condition of a compute building block, wherein the graph compiler is to, in response to obtaining the identified input condition and output condition from the selector, map the workload node to the compute building block.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating variants/versions of an audio digital component and providing a particular variant for displaying/playing on a client device. Methods can include receiving a request to generate a template for an audio digital component. Based on information in the request, the template can be generated. A first set of media data items can be linked to static media data blocks in the template. Based on the template, variants of the audio digital component can be generated and for each, media data items can be linked to the dynamic media data blocks. A request for the audio digital component can be received from a client device. A set of signals can be obtained from the client device, based on which, a particular variant of the audio digital component can be provided for display on the device.

Abstract: The present invention relates to oral therapy of a subject suffering from disease e.g. polycystic disease e.g. polycystic kidney disease or polycystic liver disease or PCOS or hypotension especially neurogenic orthostatic hypotension and postprandial hypotension, or intractable diarrhea or neuroendocrine tumors or carcinoid syndrome. The method of treatment comprises oral administration to the subject of a therapeutically effective amount of an oral somatostatin receptor ligand (SRL) e.g. oral octreotide. Combination therapy of oral SRLs with other drugs is also envisaged, e.g. octreotide in combination with a therapeutically effective amount of a second therapeutic agent and optionally in combination with a therapeutically effective amount of a third therapeutic agent.

Abstract: Systems and methods for imaging in the short wave infrared (SWIR), photodetectors with low dark current and associated circuits for reducing dark currents and methods for generating image information based on data of a photodetector array. A SWIR imaging system may include a pulsed illumination source operative to emit radiation pulses in the SWIR band towards a target resulting in reflected radiation from the target; (b) an imaging receiver including a plurality of Ge PDs operative to detect the reflected SWIR radiation and a controller, operative to control activation of the receiver for an integration time during which the accumulated dark current noise does not exceed the time independent readout noise.

Abstract: An injection device comprises a needle holder that supports a needle, and a vial holder that supports a vial. A spring urges the needle holder to move towards the vial holder but that movement is restrained by a latch until the time of use. Releasing the latch primes the device by allowing the needle holder to move, whereby a proximal end of the needle pierces a septum of the vial. The latch is preferably released by rotating an actuator. The same rotation preferably frees the needle holder and vial to be advanced axially relative to the actuator, whereby a distal end of the needle can be introduced into the skin of a subject. Compressed air from a tank may be used to drive the discharge of the vial. The air tank preferably surrounds the vial and provides a broad proximal surface, against which manual pressure can be applied to the device.

Abstract: A liquid additive delivery composition for introducing an additive into a curable silicone composition may include a liquid carrier and at least one additive. The liquid carrier may include one or both of polyvinyl acetate or polyvinyl alcohol.

Abstract: The present invention provides processes for producing food products, particularly juice beverages, with reduced sugar content enriched with dietary fibers and the food products produced. The processed food products are low in calories while preserving the palatable test of the starting material, and contain beneficial amount of dietary fibers. The processed food product further contains sorbitol and gluconic acid.