Abstract: The invention relates to the production and use of Cas-encoding sequences and vectors comprising these. Aspects of the invention provide products, vectors, delivery vehicles, uses and methods for producing Cas-encoding sequences in bacterial or archaeal cells.

Abstract: A voltage balancing circuit includes a direct-current-to-direct-current (DC-to-DC) voltage converter interconnecting a first battery having a first voltage and a second battery having a second voltage, wherein the DC-to-DC converter transfers electrical power from the first battery to the second battery when the first voltage is greater than the second voltage, and transfers electrical power from the second battery to the first battery when the first voltage is less than the second voltage, and wherein the transfer of electrical power from the first battery to the second battery or from the second battery to the first battery balances the electrical power difference between the first battery and the second battery.

Abstract: A voltage converter includes a converter stage having a direct current to direct current (DC-to-DC) voltage converter, wherein the converter stage receives a first DC voltage and outputs a second DC voltage different than the first DC voltage. The voltage converter also includes a boost pre-stage having a boosting circuit and a capacitor, wherein the boost pre-stage receives a DC voltage from a battery and outputs a boosted DC voltage to the converter stage as the first voltage, wherein the boosted DC voltage is greater than the DC voltage from the battery. The boosted DC voltage of the boost pre-stage output to the converter stage provides fault resistant operation of the converter stage in the event of one or more fluctuations in an operating range of the DC voltage from the battery.

Abstract: A messaging system identifies a received message as a notification message from a conversation system in a media application. The messaging system obtains rendering information to render a current state of the conversation thread represented by the message. The message system renders the current state of the followed conversation thread, with actuators that provide interactive functionality allowing the user to interact with the conversation thread, in the message viewer of the user's messaging system.

Abstract: The present invention relates to a package seal control system (300), comprising a control unit (308), and data recording means (306) adapted to be communicatively connected to the control unit, wherein said data recording means (306) is adapted to monitor a longitudinal seal (302) extending in a direction conforming to a direction of flow of a packaging material (e.g. Tetra Pak) in a packaging and filling machine (100). The present invention further relates to its use and method for monitoring and optionally controlling the longitudinal seal (302) of a package material in a packaging and filling machine (100).

Abstract: A messaging system identifies a received message as a notification message from a conversation system in a media application. The messaging system obtains rendering information to render a current state of the conversation thread represented by the message. The message system renders the current state of the followed conversation thread, with actuators that provide interactive functionality allowing the user to interact with the conversation thread, in the message viewer of the user's messaging system.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated.

Abstract: A shifting tool for use in shifting axial position of a shiftable element in a well. The tool comprises a linkage mechanism configured to translate an independent axial force into a dedicated radial force applied to expansive elements thereof. Thus, the elements may radially expand into engagement with the shiftable element free of any substantial axial force imparted thereon. As such, a more discretely controllable shifting actuation may be attained, for example, as directed from an oilfield surface. Indeed, real-time intelligent feedback may also be made available through use of such elements in conjunction with the noted linkage mechanism.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.