Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated. This is particularly advantageous where cutting is to be applied to downhole metal based obstructions.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: An electrical motor for a submersible machine, including a stator unit having a stator core and a rotor unit that is rotatably arranged in the stator unit. The rotor unit includes a rotor core and at least one permanent magnet. The rotor core has an outer diameter that is smaller than an inner diameter of the stator core. The rotor unit includes a brake, the radially outer surface of which is inscribed on a circle having a diameter that is greater than the outer diameter of the rotor core. At least a part of the brake is arranged to abut against an inner surface of the stator core upon mutual axial displacement of the rotor unit and the stator unit. The brake is spaced-apart from the stator core when the rotor unit is in the mounted state in the stator unit.

Abstract: A technique enables anchoring of a tool in a wellbore. The technique provides traction against a well component without creating high stress concentrations that weaken the well component. An anchoring device comprises anchoring members that are selectively movable to an expanded configuration for anchoring the tool. The anchoring members have traction surfaces able to selectively engage a smooth anchoring surface of the well component at any desired location along the well component. Each traction surface is formed to facilitate traction while minimizing stress concentration.

Abstract: A bias unit having a support body in use to be integrated with a drilling assembly and rotatable therewith for drilling a borehole penetrating a geological formation. A pad is pivotally connected to the support body proximate to the leading edge of the pad. A spring-driven push rod is positioned and preloaded to engage the pad, proximate to the trailing edge of the pad, and to urge the pad outward from the support body to contact the borehole wall during drilling.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.

Abstract: A shifting tool for use in shifting axial position of a shiftable element in a well. The tool comprises a linkage mechanism configured to translate an independent axial force into a dedicated radial force applied to expansive elements thereof. Thus, the elements may radially expand into engagement with the shiftable element free of any substantial axial force imparted thereon. As such, a more discretely controllable shifting actuation may be attained, for example, as directed from an oilfield surface. Indeed, real-time intelligent feedback may also be made available through use of such elements in conjunction with the noted linkage mechanism.

Abstract: A computer implemented method, apparatus, and computer usable program code for managing messages for an instant messaging conversation. A determination is made as to whether the selected party should receive the messages already exchanged in the instant messaging conversation in response to a user input during the instant messaging conversation with respect to a selected party. The messages are sent to the selected party in response to a determination that the selected party should receive the plurality of messages.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: A system is provided that is conducive to multi-stage stimulation in a near-continuous fashion. That is, unlike conventional stimulation systems, embodiments herein may operate without the requirement of traditional plug-setting, perforating and fracturing interventions on a zone by zone basis for a cemented completion. Rather, the system is outfitted with frac sleeves that may be shifted open to expose the bore to the formation while simultaneously achieving a seal through a ball drop technique. Once more, this manner of operation is rendered practical by the sleeve being of a passable configuration such that cementing of the casing is not impeded.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: An expander has a collapsed configuration and a deployed configuration. The expander has at least one expander component that is movably coupled to another expander component. The expander may be used with a toy figure. In one implementation, each of the expander components is pivotally coupled to another expander component. The expander includes a biasing member that biases adjacent expander components away from each other.