Patents by Inventor Rui Liang
Rui Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10568876Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.Type: GrantFiled: August 31, 2015Date of Patent: February 25, 2020Assignee: Merck Sharp & Dohme Corp.Inventors: Jason Imbriglio, Rui Liang, Clare London, Kenneth Marby, James Tata, Ming You, Yusheng Xiong
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Publication number: 20190337917Abstract: Compounds of general formula (Ia), compounds of general formula (Ia?), compounds of general formula (Ib), compounds of general formula (Ib?), compounds of general formula (I), compounds of general formula (I?), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.Type: ApplicationFiled: July 16, 2019Publication date: November 7, 2019Applicant: MERCK SHARP & DOHME CORP.Inventors: Michael D. Altman, Brandon D. Cash, Wonsuk Chang, Jared N. Cumming, Andrew M. Haidle, Timothy J. Henderson, James P. Jewell, Matthew A. Larsen, Rui Liang, Jongwon Lim, Min Lu, Ryan D. Otte, Tony Siu, Benjamin Wesley Trotter, Sriram Tyagarajan
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Publication number: 20190337918Abstract: Compounds of general formula (Ia), compounds of general formula (Ia?), compounds of general formula (Ib), compounds of general formula (Ib?), compounds of general formula (I), compounds of general formula (I?), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.Type: ApplicationFiled: July 16, 2019Publication date: November 7, 2019Applicant: MERCK SHARP & DOHME CORP.Inventors: Michael D. Altman, Brandon D. Cash, Wonsuk Chang, Jared N. Cumming, Andrew M. Haidle, Timothy J. Henderson, James P. Jewell, Matthew A. Larsen, Rui Liang, Jongwon Lim, Min Lu, Ryan D. Otte, Tony Siu, Benjamin Wesley Trotter, Sriram Tyagarajan
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Patent number: 10414747Abstract: Compounds of general formula (Ia), compounds of general formula (Ia?), compounds of general formula (Ib), compounds of general formula (Ib?), compounds of general formula (I), compounds of general formula (I?), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.Type: GrantFiled: October 2, 2017Date of Patent: September 17, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Michael D. Altman, Brandon D. Cash, Wonsuk Chang, Jared N. Cumming, Andrew M. Haidle, Timothy J. Henderson, James P. Jewell, Matthew A. Larsen, Rui Liang, Jongwon Lim, Min Lu, Ryan D. Otte, Tony Siu, Benjamin Wesley Trotter, Sriram Tyagarajan
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Publication number: 20190227127Abstract: The invention provides a method for estimating a battery capacity of an electronic device. When a current or an average current of the battery is zero, a reference capacity is inquired from a look-up table based on a voltage of the battery. When a previously remaining capacity is greater than a reference capacity, a deduction process of a self-consumable capacity is performed one or more times for a previously recorded remaining capacity to obtain a new recorded remaining capacity smaller than the reference capacity. When the current of the battery is less than zero, a deduction process of a count capacity of discharging is performed one or more times for the previously recorded remaining capacity until a power of the battery is exhausted to obtain a first offset capacity. The first offset capacity is deducted from a previously recorded full charge capacity to estimate a new full charge capacity.Type: ApplicationFiled: September 28, 2018Publication date: July 25, 2019Inventor: Fang-Rui Liang
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Publication number: 20190070719Abstract: An electric hammer comprising an electric motor, a spindle coupled to the electric motor and adapted to be driven by the electric motor, an impacting member adapted to be coupled to the spindle and driven by the spindle, and a direction changing device adapted to be coupled with the impacting member. The direction changing device changes the direction of movement of the impacting member such that the kinetic energy of the impacting member is provided to an energy storage device for accumulation after the change in the direction of movement. The energy storage device is adapted to return the accumulated energy to the impacting member such that the latter generates an impacting force to an output member.Type: ApplicationFiled: October 18, 2018Publication date: March 7, 2019Inventors: Rui LIANG, Li Guo MA
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Publication number: 20180313898Abstract: Disclosed are a device and a method for testing a battery equalization circuit.Type: ApplicationFiled: October 26, 2016Publication date: November 1, 2018Inventors: Qianhui ZHANG, Liguo YAN, Xingquan QIN, Zhongke YANG, Huigen YU, Donglin CAO, Rui LIANG, Dangqing LI, Zhiqiang GUO
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Patent number: 10106574Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.Type: GrantFiled: August 11, 2016Date of Patent: October 23, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Michael D. Altman, Wonsuk Chang, Jared N. Cumming, Rui Liang, Jongwon Lim, Tony Siu, Benjamin Wesley Trotter, Quang T. Truong, Shawn P. Walsh
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Publication number: 20180244712Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.Type: ApplicationFiled: February 1, 2018Publication date: August 30, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Michael D. Altman, Brian Andresen, Wonsuk Chang, Matthew Lloyd Childers, Jared N. Cumming, Andrew Marc Haidle, Timothy J. Henderson, James P. Jewell, Rui Liang, Jongwon Lim, Hong Liu, Min Lu, Alan B. Northrup, Ryan D. Otte, Tony Siu, Benjamin Wesley Trotter, Quang T. Truong, Shawn P. Walsh, Kake Zhao
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Publication number: 20180237469Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.Type: ApplicationFiled: February 1, 2018Publication date: August 23, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Michael D. Altman, Brian Andresen, Wonsuk Chang, Matthew Lloyd Childers, Jared N. Cumming, Andrew Marc Haidle, Timothy J. Henderson, James P. Jewell, Rui Liang, Jongwon Lim, Hong Liu, Min Lu, Alan B. Northrup, Ryan D. Otte, Tony Siu, Benjamin Wesley Trotter, Quang T. Truong, Shawn P. Walsh, Kake Zhao
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Publication number: 20180093964Abstract: Compounds of general formula (Ia), compounds of general formula (Ia?), compounds of general formula (Ib), compounds of general formula (Ib?), compounds of general formula (I), compounds of general formula (I?), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.Type: ApplicationFiled: October 2, 2017Publication date: April 5, 2018Applicant: MERCK SHARP & DOHME CORP.Inventors: Michael D. Altman, Brandon D. Cash, Wonsuk Chang, Jared N. Cumming, Andrew M. Haidle, Timothy J. Henderson, James P. Jewell, Matthew A. Larsen, Rui Liang, Jongwon Lim, Min Lu, Ryan D. Otte, Tony Siu, Benjamin Wesley Trotter, Sriram Tyagarajan
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Publication number: 20170273965Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.Type: ApplicationFiled: August 31, 2015Publication date: September 28, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Jason Imbriglio, Rui Liang, Clare London, Kenneth Marby, James Tata, Ming You, Yusheng Xiong
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Publication number: 20170044206Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.Type: ApplicationFiled: August 11, 2016Publication date: February 16, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Michael D. Altman, Brian Michael Andresen, Wonsuk Chang, Matthew Lloyd Childers, Jared N. Cumming, Andrew Marc Haidle, Timothy J. Henderson, James P. Jewell, Rui Liang, Jongwon Lim, Hong Liu, Min Lu, Alan B. Northrup, Ryan D. Otte, Tony Siu, Benjamin Wesley Trotter, Quang T. Truong, Shawn P. Walsh, Kake Zhao
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Publication number: 20160348935Abstract: A system and a method for controlling a ducted air-conditioning system are provided. The system comprises: a temperature controller, configured to generate a first control instruction for controlling the ducted air-conditioning system; a mobile terminal, configured to generate a second control instruction for controlling the ducted air-conditioning system; and a conversion device, connected between the ducted air-conditioning system and the temperature controller, communicating with the mobile terminal via wireless communication, and configured to receive the first control instruction from the temperature controller, and transmit the first control instruction to the ducted air-conditioning system, and to receive the second control instruction from the mobile terminal, convert the second control instruction into a third control instruction, and transmit the third control instruction to the ducted air-conditioning system.Type: ApplicationFiled: August 17, 2015Publication date: December 1, 2016Inventors: Jie YAN, Rui LIANG
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Patent number: 9380000Abstract: A system for deploying a Service-Oriented Architecture (SOA) deployment environment model and a system for modifying a deployed SOA deployment environment model. In the deploying system, deployment of the SOA deployment environment model is realized by acquiring a task list including tasks for deploying elements of the model, associating the tasks in the task list with the elements, and executing the tasks to deploy the elements of the model. In the modifying system, modification of the SOA deployment environment model is realized by acquiring a task list including tasks for modifying elements of the model, associating the tasks in the task list with the elements, and executing the tasks to modify the elements. Thus, the deployment of the SOA deployment environment model and the modification of the deployed SOA deployment environment model may be realized in a simple and easy-to-implement manner.Type: GrantFiled: April 24, 2013Date of Patent: June 28, 2016Assignee: International Business Machines CorporationInventors: Srikanth Bhattiprolu, Xiang Yu Cai, Rui Liang, Jun Jie Nan, Piotr Przybylski
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Patent number: 9380001Abstract: A method for deploying a Service-Oriented Architecture (SOA) deployment environment model and a method for modifying a deployed SOA deployment environment model. In the deploying method, deployment of the SOA deployment environment model is realized by acquiring a task list including tasks for deploying elements of the model, associating the tasks in the task list with the elements, and executing the tasks to deploy the elements of the model. In the modifying method, modification of the SOA deployment environment model is realized by acquiring a task list including tasks for modifying elements of the model, associating the tasks in the task list with the elements, and executing the tasks to modify the elements. Thus, the deployment of the SOA deployment environment model and the modification of the deployed SOA deployment environment model may be realized in a simple and easy-to-implement manner.Type: GrantFiled: September 16, 2014Date of Patent: June 28, 2016Assignee: International Business Machines CorporationInventors: Srikanth Bhattiprolu, Xiang Yu Cai, Rui Liang, Jun Jie Nan, Piotr Przybylski
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Patent number: 9284301Abstract: The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.Type: GrantFiled: March 22, 2011Date of Patent: March 15, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Darby Schmidt, Subharekha Raghavan, John Stelmach, Jian Guo, Jonathan Groeper, Linda Brockunier, Keith Rosauer, Hong Shen, Rui Liang, Fa-Xiang Ding
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Patent number: 9247008Abstract: A uniform approach for web service discovery is provided through common auto-discovery logic for cloud-based or enterprise-based deployments for a specific web service. Appropriate credentials may be applied employing a uniform method using an appropriate authentication scheme for on-premise, fully hosted, or partially hosted auto-discovered web services. A common interface may be implemented even if the protocols for discovery differ from service to service or between cloud-based deployment and enterprise-based deployment for the same service. Web service locations auto-discovered through different protocols may be cached for subsequent use.Type: GrantFiled: March 18, 2010Date of Patent: January 26, 2016Assignee: Microsoft CorporationInventors: Ranjith Narayanan, Rui Liang, Srivatsa Srinivasan
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Publication number: 20150169509Abstract: A method and apparatus is described for rendering web pages by a wireless device in order to reduce an amount of data transmitted over-the-air to the wireless device. In one embodiment, a method is performed by a server, comprising receiving a markup language document from a web server via a network interface, the markup language document corresponding to a web page. Next, the markup language document is parsed into a number of blocks by a processor, each of the blocks comprising code representing original content of the web page. Then, the processor creates one or more replacement blocks, each of the replacement blocks corresponding to a respective one of the blocks, each of the replacement blocks comprising code representing substituted content of the web page. Some of the blocks and at least one of the replacement blocks are then sent to a wireless device for rendering.Type: ApplicationFiled: December 15, 2013Publication date: June 18, 2015Inventors: Aravind Seshadri, Anand Muthurajan, Jyh-Han Lin, Ke-Cheng Huang, Patrick Plaisted, Rui Liang
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Patent number: D804786Type: GrantFiled: December 16, 2016Date of Patent: December 12, 2017Inventor: Rui Liang