Abstract: The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of ?-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

Abstract: Contacts lists are dynamically managed in association with communication and collaboration applications and devices. Automated and user defined factors are determined based on information from various resources such as user profile, contact information, past communication information, application/device types, and comparable ones. Factors may be weighted and employed to prioritize contacts lists under different circumstances. Prioritized contacts lists may be provided to a user, stored, updated, or otherwise processed.

Abstract: A pluggable token provider model for message level authentication across multiple web services is provided. Web service and token provider implementations within a client application are separated from an actual component that operates the business logic to formulate and understand a web request. The web service components may request web services to be executed and supply the body for the web service message while a common framework maintains the web services metadata, which includes definitions associated with respective tokens. The framework may further maintain token provider implementations that actually fetch authentication tokens and perform the web requests.

Abstract: A method and a system for deploying a Service-Oriented Architecture (SOA) deployment environment model and a method and a system for modifying a deployed SOA deployment environment model. In the deploying method, deployment of the SOA deployment environment model is realized by acquiring a task list including tasks for deploying elements of the model, associating the tasks in the task list with the elements, and executing the tasks to deploy the elements of the model. In the modifying method, modification of the SOA deployment environment model is realized by acquiring a task list including tasks for modifying elements of the model, associating the tasks in the task list with the elements, and executing the tasks to modify the elements. Thus, the deployment of the SOA deployment environment model and the modification of the deployed SOA deployment environment model may be realized in a simple and easy-to-implement manner.

Abstract: Software applications are enabled with multimodal communication capabilities and features associated with enhanced communication systems through a communication application programming interface (API). Applications for document processing, scheduling, audio/video data processing, and/or business operations can exchange communication system data and parameters bi-directionally with components of an enhanced communication system, initiate communication sessions through the application's user interface, and preserve post-communication updates.

Abstract: Glucagon receptor antagonist compounds of formula I are disclosed: The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract: The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

Abstract: The disclosure relates to program debugging. More particularly, the disclosure relates to technology for debugging a program without restarting a virtual machine. Embodiments may provide a program debug method in a virtual machine environment, the program running on the virtual machine, the method comprising receiving a request for debugging a program, instrumenting debug logic code into code to be debugged of the program, and running the program code with the debug logic code instrumented, to debug the program.

Abstract: Software applications are enabled with multimodal communication capabilities and features associated with enhanced communication systems through a communication application programming interface (API). Applications for document processing, scheduling, audio/video data processing, and/or business operations can exchange communication system data and parameters bi-directionally with components of an enhanced communication system, initiate communication sessions through the application's user interface, and preserve post-communication updates.

Abstract: An apparatus for processing digital audio-visual data including a module class manager configured to evaluate code to determine an interpretative language in which the code is written, wherein the interpretative language is selected from a plurality of interpretative languages, and an interpreter specific to the interpretative language, wherein the interpreter is configured to interpret and execute the code.

Abstract: A uniform approach for web service discovery is provided through common auto-discovery logic for cloud-based or enterprise-based deployments for a specific web service. Appropriate credentials may be applied employing a uniform method using an appropriate authentication scheme for on-premise, fully hosted, or partially hosted auto-discovered web services. A common interface may be implemented even if the protocols for discovery differ from service to service or between cloud-based deployment and enterprise-based deployment for the same service. Web service locations auto-discovered through different protocols may be cached for subsequent use.

Abstract: A pluggable token provider model for message level authentication across multiple web services is provided. Web service and token provider implementations within a client application are separated from an actual component that operates the business logic to formulate and understand a web request. The web service components may request web services to be executed and supply the body for the web service message while a common framework maintains the web services metadata, which includes definitions associated with respective tokens. The framework may further maintain token provider implementations that actually fetch authentication tokens and perform the web requests.

Abstract: Contacts lists are dynamically managed in association with communication and collaboration applications and devices. Automated and user defined factors are determined based on information from various resources such as user profile, contact information, past communication information, application/device types, and comparable ones. Factors may be weighted and employed to prioritize contacts lists under different circumstances. Prioritized contacts lists may be provided to a user, stored, updated, or otherwise processed.

Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract: A storage object such as a virtual disk drive or a raw logical volume is contained in a UNIX compatible file so that the file containing the storage object can be exported using the NFS or CIFS protocol and shared among UNIX and MS Windows clients or servers. The storage object can be replicated and backed up using conventional file replication and backup facilities without disruption of client access to the storage object. For client access to data of the storage object, a software driver accesses the file containing the storage object. For example, a software driver called a virtual SCSI termination is used to access a file containing a virtual SCSI disk drive. Standard storage services use the SCSI over IP protocol to access the virtual SCSI termination. An IP replication or snapshot copy facility may access the file containing the virtual SCSI disk drive using a higher-level protocol.

Abstract: Compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof is disclosed. The compounds are useful for treating diabetes, inflammation, atherosclerosis, hypertension, pain and the like. Pharmaceutical compositions and methods of use are also included.

Abstract: Substituted aryl and heteroaryl derivatives are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract: Architecture that automatically breaks the circular reference between objects without any different logic by introducing a helper object called a child object container. The child object is contained within the container object and both share a reference counter. The parent object holds a strong reference to the container object. When adding a reference to the child object both the shared reference counter and the parent reference counter increase. When releasing a reference to the child object both the shared reference counter and the parent reference counter decrease. This approach provides a systematic way of solving the circular reference problem that does not rely on any weak-reference feature provided by the programming language.

Abstract: Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.