Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: The present disclosure provides a display device, a method for controlling the display device, and a display apparatus. The display device includes a plurality of source signal output terminals, a plurality of data lines, a plurality of scan lines, a pixel unit array, and a switching module. When the display device displays a three-dimensional picture, a source signal output terminal provides a data signal to only one sub-pixel. When the display device displays a two-dimensional picture, a source signal output terminal simultaneously provides data signals to two rows and columns of four sub-pixels of the same luminous color.

Abstract: In accordance with the purpose(s) of the present disclosure, described herein are methods for treating cancer associated with a Ras mutation in a subject in need of treatment comprising administering to the subject an effective amount of a compound of formula I as described herein or a pharmaceutically acceptable salt thereof. The compounds described herein have improved efficacy compared to the benchmark BET inhibitor JQ-1 and comparable efficacy to high dose JQ-1 with respect to the treatment of PDAC. In one aspect, the compounds are administered in combination with an effective amount of an immune checkpoint inhibitor such as, for example, PD-1/PD-L 1 inhibitor, a CTLA-4 inhibitor, or a combination thereof.

Abstract: The present disclosure provides a display device, a method for controlling the display device, and a display apparatus. The display device includes a plurality of source signal output terminals, a plurality of data lines, a plurality of scan lines, a pixel unit array, and a switching module. When the display device displays a three-dimensional picture, a source signal output terminal provides a data signal to only one sub-pixel. When the display device displays a two-dimensional picture, a source signal output terminal simultaneously provides data signals to two rows and columns of four sub-pixels of the same luminous color.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds and methods for activating NAMPT in a subject. The compounds described herein are useful in treating a neurological disorder, disease, or condition. In another aspect, compounds described herein are useful in treating metabolic disorders and diabetes.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: Provided herein are PLpro inhibitors and methods of treating and/or preventing an infection caused by a coronavirus by administration of one or more of said PLpro inhibitors to a subject in need thereof, as well as pharmaceutical formulations and kits for use in these methods.

Abstract: A thermoelectric array display and a manufacturing method thereof are provided. The thermoelectric array display includes at least a first pixel, where the first pixel includes a bottom electrode, a P-type thermoelectric leg, an N-type thermoelectric leg, and a top electrode; the P-type thermoelectric leg is arranged on the bottom electrode; and the P-type thermoelectric leg is connected in series to the N-type thermoelectric leg by the top electrode. The thermoelectric array display has strong concealment of information transmission, can effectively reduce heat generation of a device, and can implement long-distance signal transmission.

Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.

Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A method for estimating the state of charge (SOC) of a lithium-ion battery system based on artificial intelligence (AI) is provided. In the method, the relationship between the charging data segments and the SOC of the battery system is established through deep learning, and the SOC at any stage of the charging process can be corrected. SOC in a discharging process is estimated through ampere-hour integration. The estimation method is adaptively updated with a change in the working state of the battery system.

Abstract: A lithium-ion battery system and a control method for combined internal and external heating are provided. A battery is heated in a low-temperature environment through combined internal and external heating. The energy released during self-heating of the battery is fully used, and rapid heating of the battery in the low-temperature environment is implemented. A current adjustment module in a heating module is controlled to adjust a switch on-off frequency and a current on-off time during the heating, and loops with different heating resistances in a multi-loop heating film are selected through a resistance adjustment switch. In this way, target heating requirements of the battery are met, such as a high heating rate in a low-temperature environment, low energy consumption during the heating, and a small impact on battery life without jeopardizing safety during the heating.

Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A method for estimating the state of charge (SOC) of a lithium-ion battery system based on artificial intelligence (AI) is provided. In the method, the relationship between the charging data segments and the SOC of the battery system is established through deep learning, and the SOC at any stage of the charging process can be corrected. SOC in a discharging process is estimated through ampere-hour integration. The estimation method is adaptively updated with a change in the working state of the battery system.

Abstract: An artificial intelligence (AI)-based charging curve reconstruction and state estimation method for a lithium-ion battery is provided to estimate various states of a battery. In the method, a complete charging curve is reconstructed through deep learning with charging data segments as input. Then, a plurality of states of the battery can be extracted from the complete charging curve, including a maximum capacity, maximum energy, a state of charge (SOC), a state of energy (SOE), a state of power (SOP), and a capacity increment curve. The battery charging curve reconstruction and state estimation method is adaptively updated with a change in a working state of the battery.

Abstract: A lithium-ion battery system and a control method for combined internal and external heating are provided. A battery is heated in a low-temperature environment through combined internal and external heating. The energy released during self-heating of the battery is fully used, and rapid heating of the battery in the low-temperature environment is implemented. A current adjustment module in a heating module is controlled to adjust a switch on-off frequency and a current on-off time during the heating, and loops with different heating resistances in a multi-loop heating film are selected through a resistance adjustment switch. In this way, target heating requirements of the battery are met, such as a high heating rate in a low-temperature environment, low energy consumption during the heating, and a small impact on battery life without jeopardizing safety during the heating.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.

Abstract: A FPC board and a method for manufacturing the same and an OLED display device are provided. The FPC board includes a substrate, a first wire layer disposed on one side of the substrate, a circuit board terminal disposed at an edge on one side of the substrate and connected to the first wire layer, and a first protective layer covering the first wire layer. The thickness of the circuit board terminal is larger than the sum of the thicknesses of the first wire layer and the first protective layer. When the FPC board is connected to the OLED panel, one side of the base substrate on which the panel terminal is provided is opposite to one side of the substrate on which the circuit board terminal is provided, such that the base substrate overlaps with the substrate to connect the circuit board terminal and the panel terminal.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.