Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A display panel and a manufacturing method thereof are provided. The display panel includes a substrate, and a first connecting line, a second connecting line, a first GOA circuit, and a second GOA circuit disposed on the substrate. The first GOA circuit is disposed opposite to the second GOA circuit, and a first single-sided driving area and a second single-sided driving area are sequentially disposed between the first GOA circuit and the second GOA circuit. The first connecting line is disposed in the first single-sided driving area and connected to an input terminal of the first GOA circuit, and the second connecting line is disposed in the second single-sided driving area and connected to an input terminal of the second GOA circuit. The present disclosure can prevent screen tearing which is caused by single-sided driving when performing an aging test, and improve a yield of the display panel.

Abstract: The display panel test circuit includes a first signal line, a first control line and a plurality of switching units, the first signal line comprises a first sub-signal line, a second sub-signal line and a plurality of third sub-signal lines, two ends of each of the third sub-signal lines are connected to the first sub-signal line and the second sub-signal line respectively. Each switching unit includes a first switching device, a control end thereof is connected to the first control line, an input end thereof is connected to the first sub-signal line, the output end of the first switching device is a test signal output end of the switching unit to which the first switching device belongs, and a portion of the first sub-signal line between any two adjacent switching units is connected to at least one third sub-signal line.

Abstract: A display panel test circuit and a display panel. The display panel test circuit includes a first signal line, a first control line and a plurality of switching units, the first signal line comprises a first sub-signal line, a second sub-signal line and a plurality of third sub-signal lines, two ends of each of the third sub-signal lines are connected to the first sub-signal line and the second sub-signal line respectively. Each switching unit includes a first switching device, a control end thereof is connected to the first control line, an input end thereof is connected to the first sub-signal line, the output end of the first switching device is a test signal output end of the switching unit to which the first switching device belongs, and a portion of the first sub-signal line between any two adjacent switching units is connected to at least one third sub-signal line.

Abstract: A display panel and a manufacturing method thereof are provided. The display panel includes a substrate, and a first connecting line, a second connecting line, a first GOA circuit, and a second GOA circuit disposed on the substrate. The first GOA circuit is disposed opposite to the second GOA circuit, and a first single-sided driving area and a second single-sided driving area are sequentially disposed between the first GOA circuit and the second GOA circuit. The first connecting line is disposed in the first single-sided driving area and connected to an input terminal of the first GOA circuit, and the second connecting line is disposed in the second single-sided driving area and connected to an input terminal of the second GOA circuit. The present disclosure can prevent screen tearing which is caused by single-sided driving when performing an aging test, and improve a yield of the display panel.

Abstract: The present invention relates to a rapid low-temperature self-heating method and device for a battery. Active controllable large-current lossless short-circuit self-heating cooperates with an external heater to implement rapid composite heating, so that a battery is rapidly heated in a low-temperature environment and is controlled to fall within an optimal working temperature interval, so as to improve energy utilization of the battery and durability of a battery system. Before the battery system is started, battery temperature is first determined; when the temperature is less than a threshold, an external short-circuit is first proactively triggered to generate a large current to implement self-heating inside the battery. The method is simple, easy to implement, and safe and reliable, and can effectively resolve a problem that an electric vehicle has large capacity degradation and poor working performance in a low-temperature severe cold working condition.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: A display panel includes a frame region and a display region. The frame region includes a substrate, a base layer, a voltage signal trace, a planar layer, and a lead-out trace, and a packaging layer. The packaging layer extends to an outer side of the planar layer and is connected to the substrate. The display region includes an anode, and the lead-out trace extends outward from a side of the anode and overlaps the voltage signal trace. A length of an overlapping portion between the lead-out trace and the voltage signal trace is greater than a length of an orthographic projection of the overlapping portion on the substrate.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.

Abstract: A FPC board and a method for manufacturing the same and an OLED display device are provided. The FPC board includes a substrate, a first wire layer disposed on one side of the substrate, a circuit board terminal disposed at an edge on one side of the substrate and connected to the first wire layer, and a first protective layer covering the first wire layer. The thickness of the circuit board terminal is larger than the sum of the thicknesses of the first wire layer and the first protective layer. When the FPC board is connected to the OLED panel, one side of the base substrate on which the panel terminal is provided is opposite to one side of the substrate on which the circuit board terminal is provided, such that the base substrate overlaps with the substrate to connect the circuit board terminal and the panel terminal.

Abstract: Disclosed herein are 18F-labeled compounds and compositions thereof. Also disclosed are methods of imaging estrogen receptor expressing tissues, or methods of identifying cancer lesions using these compounds.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: The present invention relates to a rapid low-temperature self-heating method and device for a battery. Active controllable large-current lossless short-circuit self-heating cooperates with an external heater to implement rapid composite heating, so that a battery is rapidly heated in a low-temperature environment and is controlled to fall within an optimal working temperature interval, so as to improve energy utilization of the battery and durability of a battery system. Before the battery system is started, battery temperature is first determined; when the temperature is less than a threshold, an external short-circuit is first proactively triggered to generate a large current to implement self-heating inside the battery. A method for determining a large-current lossless short-circuit time threshold is disclosed.

Abstract: A display panel includes a frame region and a display region. The frame region includes a substrate, a base layer, a voltage signal trace, a planar layer, and a lead-out trace, and a packaging layer. The packaging layer extends to an outer side of the planar layer and is connected to the substrate. The display region includes an anode, and the lead-out trace extends outward from a side of the anode and overlaps the voltage signal trace. A length of an overlapping portion between the lead-out trace and the voltage signal trace is greater than a length of an orthographic projection of the overlapping portion on the substrate.

Abstract: An optical fiber connector, comprising a main shaft, a connecting piece, and a lock cap. The main shaft comprises a head end and a tail end that is away from the head end. A through hole extending from the head end to the tail end is disposed in the main shaft. The connecting piece is fixedly connected to the head end and partially accommodated in the through hole. The lock cap includes a sealing portion and a connection portion that is connected to a side of the sealing portion. The sealing portion is rotationally connected to an outer side of the head end. The connection portion is located on a side that is of the head end and that is away from the tail end.

Abstract: This invention is benzothiophene-based selective mixed estrogen receptor downregulators and their compositions and uses to treat estrogen-related disorders.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: Garbage collection in a first node server of an in-memory replication system includes: in response to a garbage collection trigger in the first node server, determining whether identification information for a data object eligible for garbage collection in the first node server has been received by the first node server from at least a second node server in the in-memory replication system; and if the identification information has been received from at least the second node server, performing garbage collection on the data object with the first node server.