Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.

Abstract: A medication delivery device usable with a medication container wherein advancement of a piston within the container expels medication. The device includes a housing and a drive assembly. The drive assembly includes a drive ribbon having distal and proximal edge sections. The drive ribbon has a retracted configuration defining a spiral and an extended configuration defining a helix. The drive ribbon is movable from the retracted configuration to the extended configuration with the movement defining a drive axis and advancing the piston. In some embodiments, the drive ribbon may not rotate as the drive ribbon is advanced while in other embodiments, the ribbon does rotate. Disclosed drive assemblies include manually driven assemblies, spring driven assemblies and motor driven assemblies. The container may be replaceable to allow for reuse of the device. In some embodiments, replaceable cartridges which include both the medication container and the drive ribbon are employed.

Abstract: Systems, methods, and non-transitory computer-readable media are disclosed for automatic tagging of videos. In particular, in one or more embodiments, the disclosed systems generate a set of tagged feature vectors (e.g., tagged feature vectors based on action-rich digital videos) to utilize to generate tags for an input digital video. For instance, the disclosed systems can extract a set of frames for the input digital video and generate feature vectors from the set of frames. In some embodiments, the disclosed systems generate aggregated feature vectors from the feature vectors. Furthermore, the disclosed systems can utilize the feature vectors (or aggregated feature vectors) to identify similar tagged feature vectors from the set of tagged feature vectors. Additionally, the disclosed systems can generate a set of tags for the input digital videos by aggregating one or more tags corresponding to identified similar tagged feature vectors.

Abstract: A method for determining discharge area in hydraulic stimulation operations is provided that includes obtaining one or more treatment data inputs from a well system, and determining a discharge area by applying the one or more treatment data inputs to a function that determines discharge area in terms of volumetric flow rate of the fracturing fluid, wherein the discharge area is a total area of all downhole exits through which the fracturing fluid exits a wellbore into a subterranean formation.

Abstract: A gear forming tool includes an outer sleeve having an outer sleeve aperture and an inner sleeve having an inner sleeve aperture in fluid communication with the outer sleeve aperture, a tool holder disposed within the outer sleeve, and a 3D printed gear cutting tool with a plurality of tool cutting edges and a plurality of capillaries attached to the tool holder. The tool holder has a plurality of fluid channels configured to be in fluid communication with the inner sleeve aperture and the plurality of capillaries of the 3D printed gear cutting tool such that cutting fluid flows through the outer sleeve, the inner sleeve, the plurality of fluid channels of the tool holder, and the plurality of capillaries to the plurality of tool cutting edges.

Abstract: Described herein are chimeric proteins, specifically membrane-cleavable chimeric systems. Also described herein are nucleic acids, cells, and methods directed to the same.

Abstract: An apparatus and methods are provided for a sawblade sharpener for extending the operating life of oscillating multi-tool sawblades. The sawblade sharpener comprises a first blade that includes a multiplicity of cutting teeth. A second blade is pivotally coupled with the second blade and includes a multiplicity of cutting teeth. The cutting teeth are configured to shear off a dulled cutting edge from the sawblade and form a new cutting edge, thereby providing a sharpened sawblade. The cutting teeth may have a size and shape suitable for forming any of course cutting teeth, medium cutting teeth, fine cutting teeth, or very fine cutting teeth, and the like. The sawblade sharpener may be operated by hand, such as by squeezing handles coupled with the first and second blades or may be configured to be mounted onto a tabletop or workbench and operated by way of a lever.

Abstract: A portable bridge includes a first end segment and a second end segment spaced apart. The first end segment and the second end segment are placed on opposite sides of an obstacle to be spanned by the portable bridge. A spanning segment is coupled between the first end segment and the second end segment for spanning the obstacle. The first end segment, the second end segment, and the spanning segment each include a plurality of parallel beams distributed across a width of the portable bridge. The plurality of parallel beams are aligned along a length of the portable bridge and the plurality of parallel beams are fixed to a top plate and a bottom plate.

Abstract: A gear system includes a gear assembly having a shaft that is at least partially disposed within a housing of the gear system. A thrust bearing has inner and outer races with the outer race coupled to the housing. A bearing flexure is disposed between the inner race of the thrust bearing and the shaft. The bearing flexure includes a cylindrical cage having at least one shaft journal ring and a plurality of circumferentially distributed axially extending fingers coupled thereto with the shaft journal ring coupled to the shaft. A cylindrical bearing journal has inner and outer surfaces with the outer surface coupled to the inner race of the thrust bearing. Each of a plurality of circumferentially distributed radially extending struts extends between one of the fingers and the inner surface of the cylindrical bearing journal. The bearing flexure has an axial stiffness that is greater than its radial stiffness.

Abstract: A method for regenerating a deNOx catalyst includes contacting the catalyst with steam at a temperature in the range of from 250 to 390° C. The method also includes reducing the amount of nitrogen oxide components in a process gas stream that includes a) contacting the process gas with a deNOx catalyst which results in the conversion of nitrogen oxide components as well as a decline in the NOx conversion over the deNOx catalyst; and b) regenerating the deNOx catalyst to improve the NOx conversion by contacting the deNOx catalyst with steam at a temperature in the range of from 250 to 390° C.

Abstract: A gear system includes a gear assembly having a shaft that is at least partially disposed within a housing of the gear system. A thrust bearing has inner and outer races with the outer race coupled to the housing. A bearing flexure is disposed between the inner race of the thrust bearing and the shaft. The bearing flexure includes a cylindrical cage having at least one shaft journal ring and a plurality of circumferentially distributed axially extending fingers coupled thereto with the shaft journal ring coupled to the shaft. A cylindrical bearing journal has inner and outer surfaces with the outer surface coupled to the inner race of the thrust bearing. Each of a plurality of circumferentially distributed radially extending struts extends between one of the fingers and the inner surface of the cylindrical bearing journal. The bearing flexure has an axial stiffness that is greater than its radial stiffness.

Abstract: The present invention includes devices and systems which detect an are flash electrical fault by calculating the rate of change in ultraviolet light, infrared light, and electrical current. This ensures compliance of plant electrical systems with 29 U.S.C. § 651 et seq. (1970), 29 CFR § 1910333, NFPA 70E and IEEE 1584 Standard. The devices and systems simultaneously provide a means for maintenance personnel to reduce long time, long time delay, short time, short time delay, instantaneous, ground fault, ground fault delay, and trip functions in the electronic trip units of typical low voltage breakers from a remote location outside the arc flash boundary. The devices and systems can also be controlled from a cloud-based computer which can be the host for the system operating software.

Abstract: A drivetrain for an aircraft includes an engine, a driveshaft receiving rotational energy from the engine and a gearbox including a planetary gear system receiving rotational energy from the driveshaft. The planetary gear system includes a sun gear, planet gears, a ring gear and an integral carrier forming flexured carrier posts. Each flexured carrier post supports a respective one of the planet gears and has a fixed proximal end and a cantilevered distal end. The planetary gear system includes flexured roller races, each having a fixed end and a cantilevered end. The fixed end of each flexured roller race is coupled to the cantilevered distal end of a respective flexured carrier post. The planet gears engage with the flexured roller races to rotate about the flexured carrier posts. The cantilevered ends of the flexured roller races experience cantilevered motion to absorb loads from the planet gears.

Abstract: Systems, methods, and devices for treating a subject are described herein. In some embodiments, an applicator for selectively affecting a subject's subcutaneous tissue is provided. The applicator can include: a housing; a treatment cup mounted in the housing, wherein the treatment cup defines a tissue-receiving cavity and includes a temperature-controlled surface; at least one thermal device coupled to the treatment cup and configured to receive energy via a flexible connector coupled to the applicator and to cool the temperature-controlled surface; an at least one vacuum port coupled to the treatment cup and configured to provide a vacuum to draw the subject's tissue into the tissue-receiving cavity and against at least a portion of a treatment area of the temperature-controlled surface to selectively damage and/or reduce the subject's subcutaneous tissue.

Abstract: A gear forming tool includes an outer sleeve having an outer sleeve aperture and an inner sleeve having an inner sleeve aperture in fluid communication with the outer sleeve aperture, a tool holder disposed within the outer sleeve, and a 3D printed gear cutting tool with a plurality of tool cutting edges and a plurality of capillaries attached to the tool holder. The tool holder has a plurality of fluid channels configured to be in fluid communication with the inner sleeve aperture and the plurality of capillaries of the 3D printed gear cutting tool such that cutting fluid flows through the outer sleeve, the inner sleeve, the plurality of fluid channels of the tool holder, and the plurality of capillaries to the plurality of tool cutting edges.

Abstract: A catalyst for the conversion of NOX and N2O comprising iron chabazite and iron beta zeolite. A method of simultaneously reducing the NOX and N2O concentration in a process gas stream comprising contacting the process gas stream with a catalyst comprising iron chabazite and iron beta zeolite under conversion conditions.

Abstract: A drivetrain for an aircraft includes an engine, a driveshaft receiving rotational energy from the engine and a gearbox including a planetary gear system receiving rotational energy from the driveshaft. The planetary gear system includes a sun gear, planet gears, a ring gear and an integral carrier forming flexured carrier posts. Each flexured carrier post supports a respective one of the planet gears and has a fixed proximal end and a cantilevered distal end. The planetary gear system includes flexured roller races, each having a fixed end and a cantilevered end. The fixed end of each flexured roller race is coupled to the cantilevered distal end of a respective flexured carrier post. The planet gears engage with the flexured roller races to rotate about the flexured carrier posts. The cantilevered ends of the flexured roller races experience cantilevered motion to absorb loads from the planet gears.

Abstract: A drivetrain for an aircraft includes an engine, a driveshaft to receive rotational energy from the engine and a gearbox including a multistage planetary gear system to receive rotational energy from the driveshaft. The multistage planetary gear system includes an integral multistage ring gear system having flanged and cantilevered ends. The integral multistage ring gear system forms a first stage ring gear at the cantilevered end and a second stage ring gear interposed between the flanged end and the first stage ring gear. The multistage planetary gear system includes a first stage sun gear, first stage planet gears and a first stage carrier. The first stage planet gears mate with the first stage ring gear. The multistage planetary gear system includes a second stage sun gear, second stage planet gears and a second stage carrier. The second stage planet gears mate with the second stage ring gear.

Abstract: A catalyst for the conversion of NOX comprising iron chabazite and iron beta zeolite and a method of reducing the NOX concentration in a process gas stream comprising contacting the process gas stream with the catalyst. The catalyst is especially useful for high temperature deNOX conversion.

Abstract: A pet service structure includes a housing including a floor, upstanding sidewalls, a ceiling, and water piping connectable to a water source. A pet fountain is disposed outside of the housing. The pet fountain includes a frame coupled to one of the sidewalls, a bowl coupled to the frame and disposed near a ground level, a water spout connected to the water piping and directed towards the bowl, and a valve configured to open and close the water spout.