Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.

Abstract: Apparatus and associated methods relate to a flexible extrusion having a number of radially extending members configured for slidable insertion into a lumen of a surgical catheter shaft. In an illustrative example, the extrusion may have a flexible wall and define an interior insert lumen extending along the longitudinal axis from a proximal end to a distal end. Each of the radially extending members may have a distal engaging surface. When the extrusion is slidably inserted, for example, into the lumen of the catheter shaft, the distal engaging surface of each of the plurality of radial extending members may slidably engage an interior surface of the catheter shaft. In some examples, the inserted extrusion may define an annular distribution of longitudinally extending channels between a proximal and a distal end of the catheter. The slidable construction may advantageously simplify assembly, for example. The channels may offer end-to-end communication.

Abstract: Apparatus and associated methods relate to a catheter manipulation handle with user interface controls for steering a catheter in situ while providing an augmented (e.g., motorized, powered and tunable precision steering, and perforation safeguards) control and feedback user experience. In an illustrative example, the catheter manipulation handle may provide motor assisted operation to automatically rotate and/or deflect a distal tip of the catheter to steer and guide the distal tip to a target location in the patient's vasculature system. The augmented feedback may include, for example, haptic feedback via the handle. Haptic, audible, and/or visual feedback via the handle may indicate, for example, proximity or engagement of the distal tip with sensitive tissue. In some examples, the handle's augmented operation may advantageously amplify feedback signals to enhance the user's perception of the patient's safety with respect to the safe passage of the distal tip through the patient's vasculature.

Abstract: Embodiments disclosed herein generally relate to a catwalk and, more specifically, to a crawler assembly for a catwalk. The catwalk includes a frame and a crawler having a plurality of leg assemblies coupled to the frame. The frame defines an interior volume of the catwalk. Each leg assembly includes a vertical leg component, a foot component, and a horizontal leg component. The foot component is coupled to the vertical leg component. The vertical leg component is configured to actuate the foot component in a vertical direction. The horizontal leg component is coupled to the vertical leg component. The horizontal leg component is configured to actuate the foot component between a stowed position substantially within the interior volume and an extended position substantially outside the interior volume.

Abstract: Described here are closure devices and methods for ligating tissue, such as the left atrial appendage, and tensioning devices and mechanism for actuating these devices. The tensioning mechanisms and devices may allow a user to apply one or more predetermined forces to a suture or other portion of the closure devices.

Abstract: A supercharger exhaust bypass system, comprises a supercharger comprising an inlet and outlet, a bypass valve connected to the supercharger outlet, a first intercooler connected to receive compressed air from the outlet of the supercharger and connected to cool and expel air, a second intercooler comprising an envelope inlet, an exhaust inlet, an exhaust outlet, an exhaust passage between the exhaust inlet and the exhaust outlet, and an envelope connected to the envelope inlet and surrounding the exhaust passage, an engine system connected to receive expelled air from the first intercooler and further connected to output exhaust to the exhaust inlet of the second intercooler, and a bypass conduit connected to the bypass valve and connected to the envelope inlet.

Abstract: Methods are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

Abstract: Described here are closure devices and methods for ligating tissue, such as the left atrial appendage, and tensioning devices and mechanism for actuating these devices. The tensioning mechanisms and devices may allow a user to apply one or more predetermined forces to a suture or other portion of the closure devices. The closure devices may comprise a suture loop releasably attached to a snare loop assembly, and a tensioning mechanism or device may be configured to tighten the suture loop and/or release the suture loop from the snare loop assembly.

Abstract: Described here are devices and systems for accessing and delivering devices to a heart. The left atrial appendage may be used as an access port to allow pericardial access to internal structures of the heart. Systems that may be used to provide access to the heart via the left atrial appendage may comprise a first access element with a first alignment member, a second access element with a second alignment member, a piercing element, and an exchange element. A piercing element may be advanced to pierce the wall of the left atrial appendage to form an access site therethrough. Optionally, an exchange element may be advanced to initiate a track between the inside and outside of the left atrial appendage, which may be used for device delivery. Some systems may further comprise a left atrial appendage stabilization device.

Abstract: A golf cart vehicle is disclosed having a suspension that includes a single suspension device that provides for a plurality of functions. In one embodiment the single suspension device includes a plurality of transverse mounted leaf springs that are longitudinally spaced apart from one another to provide a spring and control arm combined effect. The leaf springs can be coupled to a wheel, such as through a steering knuckle via a ball and socket joint. The leaf springs can further be mounted to a chassis via clamps. In one embodiment the clamps are connected to the leaf springs through resilient bushings which can be spaced apart from one another to provide an anti-roll bar effect.

Abstract: Apparatus and methods relate to a pneumatic compression therapy device configured to suggest content to the patient based on a determined disease state, the content pertaining to suggested changes in lifestyle based on a standard of care. In an illustrative embodiment, the suggested changes may include modifications to treatment location, treatment time, diet, eating habits, or sleeping schedule. Various examples may further sample the patient's health and automatically adjust a treatment parameter within a predetermined parameter range based on a history of measured parameters, such as limb volume, for example. In coordination with the therapeutic treatment, the therapy device may deliver suggested content to guide the patient to make more healthful lifestyle choices to reduce recovery time and improve patient health outcomes.

Abstract: Apparatus and associated methods relate to a wearable compression therapy system for ambulatory therapy, the system including a wearable garment having one or more inflatable chambers, and a pneumatic engine locally coupled to the garment to provide control and inflation of the one or more inflatable chambers. In an illustrative embodiment, the pneumatic engine may control a pump and one or more valves to inflate the inflatable chambers. The valves and pump may be coordinated according to a pre-programmed profile. In some embodiments, the pneumatic engine may have a wireless interface configured to receive control signals from a remote mobile device untethered from the garment. The pneumatic engine may send to the remote mobile device signals indicative of sensed conditions of the compression therapy system. In some embodiments, the pneumatic engine may include a power source that advantageously permits the user to be untethered from a source of power.

Abstract: Apparatus and associated methods relate to a pneumatic distribution system having pneumatic pump that exhausts into a common plenum that is in fluid communication with a plurality of flow controllers. In an illustrative embodiment, a system controller may coordinate the operation of the one or more pneumatic pumps and the plurality of flow controllers to provide air pressure control to a system of pneumatic chambers. In some embodiments, one of the plurality of flow controllers may be configured to provide fluid communication with an ambient atmosphere so as to permit a fluid path from a pneumatic chamber connected to another flow controller to the ambient atmosphere via both flow controllers and the common plenum. In an exemplary embodiment, the system controller may advantageously control the air pressures in a plurality of pneumatic chambers independently of one another using coordinated control of the pump and flow controllers.

Abstract: Systems, and methods relate to a medical device receiving a treatment parameter operating point within a first operating region defined by a first set of operating points for which automatic incremental adjustment of a parameter in the current operation is permitted. In an illustrative example, incremental adjustment may use artificial intelligence based on patient feedback and sensor measurement of outcomes. Some exemplary devices may receive a request to alter the current treatment parameter operating point to a second treatment parameter operating point outside the first operating region and in a second operating region in a known safe operation zone, bounded by a known unsafe zone unavailable to the user. In the second operating region, some examples may restrict the step size of incremental adjustments requested by the user. Data may be collected for cloud-based analysis, for example, to facilitate discovery of more effective treatment protocols.

Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.

Abstract: A supercharger exhaust bypass system, comprises a supercharger comprising an inlet and outlet, a bypass valve connected to the supercharger outlet, a first intercooler connected to receive compressed air from the outlet of the supercharger and connected to cool and expel air, a second intercooler comprising an envelope inlet, an exhaust inlet, an exhaust outlet, an exhaust passage between the exhaust inlet and the exhaust outlet, and an envelope connected to the envelope inlet and surrounding the exhaust passage, an engine system connected to receive expelled air from the first intercooler and further connected to output exhaust to the exhaust inlet of the second intercooler, and a bypass conduit connected to the bypass valve and connected to the envelope inlet.

Abstract: A quantitative optical microscopy arrangement is described. Specifically, a digital filter derived from linear discriminant analysis is described for recovering impulse responses in applications that may include photon counting from a high speed photodetector and applied to remove ringing distortions from impedance mismatch in multiphoton fluorescence microscopy. Training of the digital filter is achieved by defining temporally coincident and non-coincident transients and identifying the projection within filter-space that best separates the two classes. The training allows rapid data analysis by digital filtering. The LDA filter is also capable of recovering deconvolved impulses for single photon counting from highly distorted ringing waveforms from an impedance mismatched photomultiplier tube.

Abstract: Apparatus and associated methods relate to nutating a piston drive linkage oriented around a longitudinal axis in response to the rotation of a drive shaft about a drive axis, said longitudinal axis being offset and canted with respect to said drive axis. In an illustrative example, the piston drive linkage may be formed as a wobble plate extending radially from the longitudinal axis. Near a periphery, the wobble plate may attach to a plurality of stationary piston cranks. The nutating motion of the piston drive linkage may impart a substantially linear motion profile substantially parallel to the drive axis of rotation. A bearing oriented around the longitudinal axis may advantageously be freely inserted into and removed from an aperture in the wobble plate. An inner race of the bearing may freely rotate about the longitudinal axis in response to rotation about the drive axis.

Abstract: Apparatus and associated methods relate to nutating a piston drive linkage oriented around a longitudinal axis in response to the rotation of a drive shaft about a drive axis of rotation, said longitudinal axis being offset and canted with respect to said drive axis of rotation. In an illustrative example, the piston drive linkage may be formed as an umbrella shape with multiple arm members extending radially from the longitudinal axis. The distal ends of each of the radial arm members may attach to a stationary piston crank. The nutating motion of the piston drive linkage may impart a substantially linear motion profile substantially parallel to the drive axis of rotation. A shaft extending along the longitudinal axis from the piston linkage may advantageously freely insert into and rotate within a receptacle of a spinner body being rotated around the drive axis of rotation.