Abstract: The present invention provides a novel peptide that has an amino acid sequence represented by SEQ ID NO: 18, and binds to an active protease but does not bind to a pro-protease.

Abstract: Disclosed are compositions and method related to variants of SPINK2 that bind to targets other than an endogenous target of SPINK2. In one embodiment, a peptide is provided that comprises the amino acid sequence SEQ ID NO: 1. In further embodiments, an amino acid sequences encoded by nucleotide positions 4 to 42 and/or nucleotide positions 94 to 189 in the nucleotide sequence of SEQ ID NO: 14 flank the amino terminus and the carboxyl terminus, respectively, of the amino acid sequence. In another embodiment, a peptide is provided that comprises an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 1 in which a conservative substitution, deletion, addition and/or insertion of 1 to 5 (inclusive) amino acids has occurred at amino acids other than the 1st Xaa to the 12th Xaa counting from the amino terminus.

Abstract: One embodiment of the present invention is that in samarium-iron-nitrogen magnet powder, a non-magnetic phase is formed on a surface of the samarium-iron-nitrogen magnet phase, and an arithmetic mean roughness Ra of the surface is 3.5 nm or less.

Abstract: A samarium-iron-bismuth-nitrogen-based magnet powder includes: a main phase including samarium, iron, and bismuth, wherein a ratio of bismuth to a total amount of samarium, iron, and bismuth is less than or equal to 3.0 at %.

Abstract: Disclosed are compositions and method related to variants of SPINK2 that bind to targets other than an endogenous target of SPINK2. In one embodiment, a peptide is provided that comprises the amino acid sequence SEQ ID NO: 1. In further embodiments, an amino acid sequences encoded by nucleotide positions 4 to 42 and/or nucleotide positions 94 to 189 in the nucleotide sequence of SEQ ID NO: 14 flank the amino terminus and the carboxyl terminus, respectively, of the amino acid sequence. In another embodiment, a peptide is provided that comprises an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 1 in which a conservative substitution, deletion, addition and/or insertion of 1 to 5 (inclusive) amino acids has occurred at amino acids other than the 1st Xaa to the 12th Xaa counting from the amino terminus.

Abstract: To provide a rare earth permanent magnet having as a main phase a compound with a Nd5Fe17 crystalline structure having strong coercive force. A rare earth permanent magnet having as a main phase a compound with a Nd5Fe17 crystalline structure, wherein when the composition ratio of the rare earth permanent magnet is expressed as RaT(100-a-b)Cb, where R is one or more rare earth elements requiring Sm, and T is one or more transition metal elements requiring Fe or Fe and Co, a and b satisfy 18<a<40 and 0.5?b, and a phase where R and C are denser than the main phase is provided in the grain boundary phase of the rare earth permanent magnet.

Abstract: To provide a permanent magnet which uses Ce of an abundant resource and has a great magnetic anisotropy in rare earth permanent magnets. To obtain a permanent magnet having a high magnetic anisotropy due to the trivalent Ce state by setting the abundance ratio C3/(C3+C4) in the main phase grains to be 0.1?C3/(C3+C4)?0.5 where C3 denotes the number of trivalent Ce atoms and C4 denotes the number of tetravalent Ce atoms.

Abstract: A rare-earth sintered magnet contains main phase crystal grains having an Nd5Fe17-type crystal structure, includes R and T (where R represents one or more rare-earth elements that essentially include Sm and T represents Fe or one or more transition metal elements that essentially include Fe and Co), and wherein the compositional ratio of R is 20-40 at % and the remaining portion is substantially T; the remaining portion other than R is substantially only T or only T and C; and when the main phase crystal grains' average grain size in one cross-sectional surface of the rare-earth sintered magnet is defined as Dv, while grain size of individual main phase crystal grains is defined as Di, Dv is at least 1.0 ?m, and the main phase crystal grains' area ratio that satisfy 0.7Dv?Di?2.0Dv is at least 80% with respect to the area of a cross-sectional surface of the rare-earth sintered magnet.

Abstract: A reed includes: a reed main body having a plate shape, the reed main body including a fixed part fixed to a mouthpiece, and a vibrating part that extends from the fixed part and vibrates; and a sensor part that is disposed inside the vibrating part or on an inner surface of the vibrating part, the inner surface of the vibrating part facing the mouthpiece, the sensor part comprising an effective sensor portion that detects vibration of the vibrating part.

Abstract: The present disclosure provides hNGAL muteins that bind CGRP and can be used in various application including pharmaceutical applications, for example, migraine. The present disclosure also concerns methods of making one or more muteins described herein as well as compositions and combinations comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules.

Abstract: A drum head includes: a head portion in which an opening is formed along a periphery of the head portion; and a protective skin closing the opening and having air permeability.

Abstract: A drum head includes: a first film including a striking surface; a second film disposed opposed to a back surface of the first film which is back from the striking surface; and a sensor disposed between the first film and the second film and configured to output a signal related to vibration. The sensor includes: a first contact surface configured to contact the back surface of the first film without being secured to the back surface; and a second contact surface configured to contact a front surface of the second film without being secured to the front surface. A sensor tail of the sensor is secured to at least one of the first film and the second film located outside the shell when the first film and the second film are stretched over an open end of a shell.

Abstract: The present disclosure provides hNGAL muteins that bind CGRP and can be used in various application including pharmaceutical applications, for example, migraine. The present disclosure also concerns methods of making one or more muteins described herein as well as compositions and combinations comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these muteins as well as compositions and combinations comprising one or more of such muteins.

Abstract: Provided is a percussion instrument including a substantially cylindrical barrel and a weight fixed to the barrel. More specifically, a plurality of weights 5A to 5D may be provided on the inner circumferential surface of a shell 2 of a drum 1 (a percussion instrument). The weights 5A to 5D may be provided at positions where the weights 5A to 5D have four-fold rotational symmetry in the circumferential direction of the shell 2. The weights 5A to 5D may be each provided between lugs 3 that are provided adjacent to each other on the outer circumferential surface of the shell 2.

Abstract: A reed includes: a reed main body having a plate shape, the reed main body including a fixed part fixed to a mouthpiece, and a vibrating part that extends from the fixed part and vibrates; and a sensor part that is disposed inside the vibrating part or on an inner surface of the vibrating part, the inner surface of the vibrating part facing the mouthpiece, the sensor part comprising an effective sensor portion that detects vibration of the vibrating part.

Abstract: A drum head includes: a first film including a striking surface; a second film disposed opposed to a back surface of the first film which is back from the striking surface; and a sensor disposed between the first film and the second film and configured to output a signal related to vibration. The sensor includes: a first contact surface configured to contact the back surface of the first film without being secured to the back surface; and a second contact surface configured to contact a front surface of the second film without being secured to the front surface. A sensor tail of the sensor is secured to at least one of the first film and the second film located outside the shell when the first film and the second film are stretched over an open end of a shell.

Abstract: The present invention provides an R-T-B based permanent magnet suitable as a magnet with a variable magnetic force for a motor with variable magnetic flux, which has a high residual magnetic flux density, a low coercivity, and a magnetic force that can be reversibly varied by a small external magnetic field. A permanent magnet with a high residual magnetic flux density and a low coercivity that is suitable as a variable magnet for a motor with variable magnetic flux can be obtained, by selecting the rare earth elements consisting of one or more of Y, La and Ce for a predetermined amount of the rare earth element(s) R in the R-T-B based permanent magnet, and further adding a predetermined amount of the additive element(s) which is at least one of Al, Cu, Zr, Hf and Ti.

Abstract: In the present invention, a permanent magnet with excellent temperature properties and magnetic properties which will not significantly deteriorate can be stably prepared, by using a raw alloy for the R-T-B based permanent magnet in which the rare earth element(s) composed of at least one selected from the group consisting of Y, La and Ce is selected as a predetermined amount of the rare earth element R in the R-T-B based permanent magnet and a proper amount of Ca is contained.

Abstract: A drum, including: a shell; at least one head; and a vibration damping portion including at least one of (a) an outer-surface facing surface which is disposed in substantially parallel with and is closely opposed to an outer surface of an outer peripheral portion of the at least one head without contacting the outer surface and (b) an inner-surface facing surface which is disposed in substantially parallel with and is closely opposed to an inner surface of the outer peripheral portion of the at least one head without contacting the inner surface.

Abstract: A R-T-B based permanent magnet which not only has equivalent magnetic properties as the existing Nd—Fe—B based permanent magnet as well as light mass but also can be suitably used as a magnet for field system of a permanent magnet synchronous rotating machine. The magnet can be obtained in a case where the composition of the compound for forming the main phase is (R1-x(Y1-zLaz)x)2T14B (R is rare earth element(s) consisting of one or more elements of Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu, T is one or more transition metal elements with Fe or Fe and Co as essential elements, 0.0<x?0.5 and 0.0<z?0.5), by making the abundance ratio of Y4f/(Y4f+Y4g) satisfies 0.8?Y4f/(Y4f+Y4g)?1.0 when the Y occupying the 4f site of the tetragonal R2T14B structure is denoted as Y4f and the Y occupying the 4g site is denoted as Y4g.