Abstract: The present disclosure relates to novel lipocalin muteins which bind to PCSK9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules.

Abstract: A R-T-B based permanent magnet which has equivalent magnetic properties as the existing Nd—Fe—B based permanent magnet and light mass but also can be suitably used as a magnet for field system of a permanent magnet synchronous rotating machine. The magnet can be obtained in a case where the composition of the compound for forming the main phase is (R1-x(Y1-zCez)x)2T14B (R is rare earth element(s) consisting of one or more elements selected from La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu, Y is yttrium, Ce is cerium, T is one or more transition metal elements with Fe or Fe and Co as essential element(s), B is boron, 0.0<x?0.5 and 0.0?z?0.5), by making the abundance ratio of Y4f/(Y4f+Y4g) in relation to the Y occupying the 4f site of the tetragonal R2T14B structure (i.e., Y4f) and the Y occupying the 4g site (i.e., Y4g) satisfies 0.8?Y4f/(Y4f+Y4g)?1.0.

Abstract: To provide a novel compound that has S1P lyase inhibitory ability and induces a reduction in the number of lymphocytes, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the compound or pharmaceutically acceptable salt thereof as an active ingredient. A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a permanent magnet whose magnetic properties will not be significantly decreased and which is excellent in the temperature properties compared to the existing R-T-B based permanent magnet. In the R-T-B based structure, a stack structure of R1-T-B based crystallizing layer and (Y,Ce)-T-B based crystallizing layer can be formed by alternatively stacking R1-T-B and (Y,Ce)-T-B. In this way, a high magnetic anisotropy field of the R1-T-B based crystallizing layer can be maintained while an improved temperature coefficient of the (Y,Ce)-T-B based crystallizing layer can be obtained. Further, a high coercivity can be obtained by adding the Ce-T-B based crystallizing layer with a low lattice distortion to the Y-T-B based crystallizing layer.

Abstract: It is intended to provide a peptide library. The present invention provides a peptide selected from the following (1) and (2): a peptide selected from the following (i) and (ii): (i) a peptide comprising the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing and further comprising amino acid sequences encoded by nucleotide positions 8 to 42 and nucleotide positions 43 to 93 in the nucleotide sequence represented by SEQ ID NO: 14 in the Sequence Listing to flank the amino terminus and the carboxyl terminus, respectively, of the amino acid sequence; and (ii) a peptide comprising an amino acid sequence, derived from the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing, in which conservative amino acid substitution, deletion, addition and/or insertion of 1 to 5 (inclusive) amino acids has occurred, wherein said substitution, deletion, addition and/or insertion has occurred at amino acids other than the 1st Xaa to the 12th Xaa counting from the amino terminus.

Abstract: The present invention provides a permanent magnet which is excellent in the temperature properties and the magnetic properties of which will not be significantly decreased, compared to the conventional R-T-B based permanent magnet. In the R-T-B based structure, a stacked structure of R1-T-B based crystal layer and Y-T-B based crystal layer can be formed by alternatively stacking R1-T-B and Y-T-B. In this way, a high magnetic anisotropy field of the R1-T-B based crystal layer can be maintained while the temperature coefficient of the Y-T-B based crystal layer can be improved.

Abstract: The present invention provides a permanent magnet whose magnetic properties will not be significantly decreased and which is excellent in the temperature properties compared to the existing R-T-B based permanent magnet. In the R-T-B based structure, a stacked structure of R1-T-B based crystallizing layer and (Y, La)-T-B based crystallizing layer can be formed by alternatively stacking R1-T-B and (Y, La)-T-B. In this way, a high magnetic anisotropy field of the R1-T-B based crystallizing layer can be maintained while an improved temperature coefficient of the (Y, La)-T-B based crystallizing layer can be obtained. Further, the lattice distortion in the total stacked structure is moderated by setting the rare earth elements in the (Y, La)-T-B based crystallizing layer as both of Y and La, and a high residual flux density can be obtained accordingly.

Abstract: A R-T-B based permanent magnet which not only has equivalent magnetic properties as the existing Nd—Fe—B based permanent magnet but also has a high adhesive strength and which can be suitably used as a magnet for field system of a permanent magnet synchronous rotating machine. The magnet can be obtained in a case where the composition of the compound for forming the main phase is (R1-x(Ce1-zYz)x)2T14B (R is rare earth element(s) consisting of one or more elements selected from La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu, T is one or more transition metal elements with Fe or Fe and Co as essential element(s), 0.0<x?0.5 and 0.0?z?0.5), by making the abundance ratio of Ce4f/(Ce4f+Ce4g) satisfies 0.8?Ce4f/(Ce4f+Ce4g)?1.0 when the Ce occupying the 4f site of the tetragonal R2T14B structure is denoted Ce4f and the Ce occupying the 4g site is denoted as Ce4g.

Abstract: A magnetic measurement device which measures coercivity and coercivity distribution in a microregion of a thin plate magnetic sample with high coercivity. A magnetic sample is applied with a magnetic field in a first direction and magnetized, a second magnetic field is applied in a direction opposite to the first, a measuring part scans the sample, measuring magnetic flux leakage due to remnant magnetization in the sample. The intensity of the second magnetic field is gradually increased while the measuring part repeats the measurement to obtain the second magnetic field wherein the magnitude of the leakage from the sample reaches the maximum level, and when a magnetic field equivalent to the coercivity is applied to the sample and about half of the magnetization is reversed, the sample's coercivity is obtained based on the determination that the demagnetizing field Hd reaches the minimum level and the leakage reaches the maximum level.

Abstract: A snare drum 10 has a hollow cylindrical shell 11, a batter head 12 mounted on one end of the shell 11, a snare side head 13 mounted on the other end of the shell 11 and a snare wire 14 whose both ends are held by the both sides of the shell 11 to span across the surface of the snare side head 13. The snare side head 13 has a plurality of through-holes 13c. As a result, the snare drum 10 reduces sound volume while maintaining natural timbre and feeling of striking a snare drum.

Abstract: A magnetic measurement device which can measure the magnetic characteristics in a microregion of a thin plate magnetic sample. After a magnetic sample is applied by a magnetic field and magnetized accordingly, by scanning the magnetic sample using a measuring part, the magnetic flux leakage in the magnetic sample can be measured. The magnetic flux leaks outside by magnetizing a first region and a second region of the magnetic sample in reciprocally opposite directions and reducing the demagnetizing field. Specifically, a magnetic field generating part with at least a pair of magnetic poles is used to perform the magnetization of multiple poles, or the magnetic field generating part applies a damped oscillation magnetic field to perform the magnetization, or a local magnetic field generating part which applies an alternating magnetic field and scans the surface of the sample at the same time is used to perform the magnetization.

Abstract: An acoustic drum 10 has a hollow cylindrical shell 11, a drumhead 12 mounted to an opening end of the shell 11 to form a striking surface, a striking surface attachment 13a provided on the entire surface of a useful movable portion of the front side of the drumhead 12, and a striking surface attachment 13b provided on the entire surface of a useful movable portion of the reverse side of the drumhead 12. Each of the striking surface attachments 13a and 13b is formed of a resin film, with respective outer areas of the striking surface attachments 13a and 13b being fixed to the drumhead 12. As a result, the acoustic drum 10 can reduce sound volume, while maintaining struck sounds having brightness and providing a player with favorable feeling of striking.

Abstract: The present invention provides a permanent magnet whose magnetic properties will not be significantly decreased and which is excellent in the temperature properties compared to the existing R-T-B based permanent magnet. In the R-T-B based structure, a stack structure of R1-T-B based crystallizing layer and (Y,Ce)-T-B based crystallizing layer can be formed by alternatively stacking R1-T-B and (Y,Ce)-T-B. In this way, a high magnetic anisotropy field of the R1-T-B based crystallizing layer can be maintained while an improved temperature coefficient of the (Y,Ce)-T-B based crystallizing layer can be obtained. Further, a high coercivity can be obtained by adding the Ce-T-B based crystallizing layer with a low lattice distortion to the Y-T-B based crystallizing layer.

Abstract: The present invention provides a permanent magnet which is excellent in the temperature properties and the magnetic properties of which will not be significantly decreased, compared to the conventional R-T-B based permanent magnet. In the R-T-B based structure, a stacked structure of R1-T-B based crystal layer and Y-T-B based crystal layer can be formed by alternatively stacking R1-T-B and Y-T-B. In this way, a high magnetic anisotropy field of the R1-T-B based crystal layer can be maintained while the temperature coefficient of the Y-T-B based crystal layer can be improved.

Abstract: The present invention provides such a permanent magnet that its magnetic properties will not significantly decrease and it can be prepared at a lower temperature, compared to conventional R-T-B based permanent magnets. In the R-T-B based structure, a stacked structure of R1-T-B based crystal layer and Ce-T-B based crystal layer can be formed by alternatively stacking the R1-T-B based crystal layer and the Ce-T-B based crystal layer. In this way, a high magnetic anisotropy field of the R1-T-B based crystal layer can be maintained while the crystallization temperature can be lowered by the Ce-T-B based crystal layer.

Abstract: The present invention provides a permanent magnet whose magnetic properties will not be significantly decreased and which is excellent in the temperature properties compared to the existing R-T-B based permanent magnet. In the R-T-B based structure, a stacked structure of R1-T-B based crystallizing layer and (Y, La)-T-B based crystallizing layer can be formed by alternatively stacking R1-T-B and (Y, La)-T-B. In this way, a high magnetic anisotropy field of the R1-T-B based crystallizing layer can be maintained while an improved temperature coefficient of the (Y, La)-T-B based crystallizing layer can be obtained. Further, the lattice distortion in the total stacked structure is moderated by setting the rare earth elements in the (Y, La)-T-B based crystallizing layer as both of Y and La, and a high residual flux density can be obtained accordingly.

Abstract: The present invention provides a permanent magnet with excellent temperature characteristics and without magnetic properties significantly decreased compared to the existing R-T-B based magnet. By means that the R-T-B based magnet as the raw material is applied to heating treatment for a long time, the main phase grains will turn into core-shell like, and said R-T-B based magnet comprises main phase grains having core portion and shell portion that covers the core. When the mass concentration of RI and Y in the core portion is set as ?R1 and ?Y respectively and the mass concentration of R1 and Y in the shell portion is set as ?R1 and ?Y respectively, the ratio (B/A) between the mass concentration ratio of R1 to Y in the shell portion (?R1/?Y=B) and the mass concentration ratio of R1 to Y in the core portion (?R1/?Y=A) is 1.1 or more.

Abstract: The present disclosure relates to novel lipocalin muteins which bind to PCSK9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules.

Abstract: To provide a novel compound that has S1P lyase inhibitory ability and induces a reduction in the number of lymphocytes, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the compound or pharmaceutically acceptable salt thereof as an active ingredient. A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An acoustic drum 10 has a hollow cylindrical shell 11, a drumhead 12 mounted to an opening end of the shell 11 to form a striking surface, a striking surface attachment 13a provided on the entire surface of a useful movable portion of the front side of the drumhead 12, and a striking surface attachment 13b provided on the entire surface of a useful movable portion of the reverse side of the drumhead 12. Each of the striking surface attachments 13a and 13b is formed of a resin film, with respective outer areas of the striking surface attachments 13a and 13b being fixed to the drumhead 12. As a result, the acoustic drum 10 can reduce sound volume, while maintaining struck sounds having brightness and providing a player with favorable feeling of striking.